Biological markers in panic states: lactate-induced panic and mitral valve prolapse.

abstract：BACKGROUND:Identifying factors that modify responsiveness to pharmacotherapies for alcohol dependence is important for treatment planning. Cigarette smoking predicts more severe alcohol dependence and poorer treatment response in general. Nevertheless, there is limited research on cigarette smoking as a potential predi...

journal_title：Biological psychiatry

authors： Fucito LM,Park A,Gulliver SB,Mattson ME,Gueorguieva RV,O'Malley SS

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:The interactions among experience, emotion, and memory are considered to be instrumental in the ontogeny and maintenance of acquired emotional and behavioral disorders (e.g., phobias). Here we address the question whether an anxiety-like state can associate with taste to produce conditioned taste aversion (C...

journal_title：Biological psychiatry

authors： Guitton MJ,Dudai Y

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:The reported inverse relationship between indices of central serotonin (5-HT) function and indices of impulsive aggression in human subjects suggests the possibility that enhancement of 5-HT activity will reduce impulsive aggressive behavior. Although evidence for this hypothesis is emerging, the relationshi...

journal_title：Biological psychiatry

authors： Coccaro EF,Kavoussi RJ,Hauger RL

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. METHODS:We organized a multicent...

journal_title：Biological psychiatry

authors： Kunugi H,Iijima Y,Tatsumi M,Yoshida M,Hashimoto R,Kato T,Sakamoto K,Fukunaga T,Inada T,Suzuki T,Iwata N,Ozaki N,Yamada K,Yoshikawa T

更新日期：2004-09-01 00:00:00

abstract：:The present study was undertaken to investigate if acute anxiety can affect plasma concentrations of homovanillic acid (pHVA). Since elevated pHVA levels have been associated with severity of schizophrenic symptoms, the results of this study will help determine if the pHVA elevations are directly related to psychosis ...

journal_title：Biological psychiatry

authors： Zemishlany Z,Davidson M

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:The implication of serotonin in suicide and affective disease explains why the 5-HT(2A) receptor gene has been proposed as a candidate gene in these disorders, although with conflicting results. METHODS:We analysed the distribution of the 5-HT(2A)-1438A/G genetic polymorphism in 192 patients with major affe...

journal_title：Biological psychiatry

authors： Bonnier B,Gorwood P,Hamon M,Sarfati Y,Boni C,Hardy-Bayle MC

更新日期：2002-05-01 00:00:00

abstract：:Tourette syndrome (TS) is thought to involve dopaminergic disturbances, but the nature of those disturbances remains controversial. Existing hypotheses suggest that TS involves 1) supersensitive dopamine receptors, 2) overactive dopamine transporters that cause low tonic but high phasic dopamine, 3) presynaptic dysfun...

journal_title：Biological psychiatry

authors： Maia TV,Conceição VA

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Children with early-onset disruptive behavior disorder (DBD), especially those with callous-unemotional traits, are at risk of developing persistent and severe adult antisocial behavior. One possible underlying mechanism for persistence is deficient reward and loss sensitivity, i.e., deficient incentive proc...

journal_title：Biological psychiatry

authors： Cohn MD,Veltman DJ,Pape LE,van Lith K,Vermeiren RR,van den Brink W,Doreleijers TA,Popma A

更新日期：2015-11-01 00:00:00

abstract：:Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be problematic. We review the evidence from longitudinal studies that have examined this relationship and discuss the epidemiologic evidence for and against interpreting the fin...

journal_title：Biological psychiatry

authors： Gage SH,Hickman M,Zammit S

更新日期：2016-04-01 00:00:00

abstract：:The relation of stress to cancer is the subject of considerable controversy. We studied the possible influence of chronic stress on the time of development and frequency of tumors induced in rats after a single exposure to ethylnitrosourea during prenatal life. Time of development, localization, incidence, type, and s...

journal_title：Biological psychiatry

authors： Sotelo J,Palencia G,Rosas N,Perez R

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:A novel, high-affinity (.7-2.0 nmol) compound that selectively activates the alpha2, alpha 3, and alpha 5 (but not alpha1) gamma-aminobutyric acid-A (GABA(A)) receptor subtypes, TPA023B (2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl) imidazo[1,2-b][1,2,4]triazin-7-yl][1,1'-biphenyl]-2-carbonitrile) was pharma...

journal_title：Biological psychiatry

authors： Van Laere K,Bormans G,Sanabria-Bohórquez SM,de Groot T,Dupont P,De Lepeleire I,de Hoon J,Mortelmans L,Hargreaves RJ,Atack JR,Burns HD

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) is a noninvasive procedure that may be used to study individual differences in motor cortex excitability. Such differences are assumed to reflect serotonergic and other inputs to the motor cortex. METHODS:Here we investigate the impact of a functional polymorphism in ...

journal_title：Biological psychiatry

authors： Langguth B,Sand P,Marek R,Landgrebe M,Frank E,Hajak G,Eichhammer P

更新日期：2009-08-01 00:00:00

abstract：:Reduced platelet MAO activity has been previously reported as a biochemical marker for a subgroup of psychiatric patients, including some chronic schizophrenics. As tryptamine metabolism appears to be sensitive to alterations in MAO activity, urinary tryptamine excretion was measured in chronic schizophrenics with low...

journal_title：Biological psychiatry

authors： Sullivan JL,Coffey CE,Basuk B,Cavenar JO,Maltbie AA,Zung WW

更新日期：1980-02-01 00:00:00

abstract：:Sixty patients with affective illness were examined by computed tomography (CT) and compared to 60 age- and sex-matched controls. Using three different methods of measurement, no differences in ventricular brain ratio (VBR) between patients and controls could be detected. However, linear ventricular values of the fron...

journal_title：Biological psychiatry

authors： Schlegel S,Kretzschmar K

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Shared neuropathological characteristics of patients with schizophrenia and their siblings might represent intermediate phenotypes that could be used to investigate genetic susceptibility to the illness. We sought to discover previously unidentified gray matter volume differences in patients with schizophren...

journal_title：Biological psychiatry

authors： Honea RA,Meyer-Lindenberg A,Hobbs KB,Pezawas L,Mattay VS,Egan MF,Verchinski B,Passingham RE,Weinberger DR,Callicott JH

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:This study examined the hypothesis that allelic variants of the ionotropic glutamatergic N-methyl-D-aspartate receptor (NMDAR) are associated with vulnerability to alcoholism and some related traits. METHODS:We investigated the silent G2108A and C2664T polymorphisms of the NMDAR1 and the NMDAR2B genes, resp...

journal_title：Biological psychiatry

authors： Wernicke C,Samochowiec J,Schmidt LG,Winterer G,Smolka M,Kucharska-Mazur J,Horodnicki J,Gallinat J,Rommelspacher H

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Family studies of Obsessive-Compulsive (OCD) indicate there is substantial heterogeneity in the familiality of the disorder. This study was done to determine whether there are differences between familial and sporadic probands with early-onset OCD in obsessive-compulsive (OC) symptom categories and comorbid ...

journal_title：Biological psychiatry

authors： Hanna GL,Fischer DJ,Chadha KR,Himle JA,Van Etten M

更新日期：2005-04-15 00:00:00

abstract：:The relationship between plasma kynurenine (KYN) concentration and anxiety and depression in psychiatric patients was examined. KYN has been reported as a probable endogenous anxiogen in animal models of anxiety. Thirty patients with affective states were studied. The Hamilton Anxiety Scale (HAM-A), Hamilton Depressio...

journal_title：Biological psychiatry

authors： Orlikov AB,Prakhye IB,Ryzov IV

更新日期：1994-07-15 00:00:00

abstract：:The effects of changes in pCO2 in the development and resolution of normal (return to base line within 2 sec after S2) and abnormal (return to base line in more than 2 sec after S2) CNVs were studied. Decreased pCO2 produced by hyperventilation induced a significant reduction in the duration of the post-imperative neg...

journal_title：Biological psychiatry

authors： Dubrovsky B,Garcia-Rill E,Simkus R,Dongier M

更新日期：1976-10-01 00:00:00

abstract：:Since publication of the first randomized controlled trial describing rapid antidepressant effects of ketamine, several reports have confirmed the potential utility of this dissociative anesthetic medication for treatment of major depressive episodes, including those associated with bipolar disorder and resistant to o...

journal_title：Biological psychiatry

authors： Aan Het Rot M,Zarate CA Jr,Charney DS,Mathew SJ

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Effects of the hypothalamic-pituitary-adrenal (HPA) axis on central dopaminergic systems have been proposed to underlie the development of psychotic symptoms in depression. This study examined HPA axis hormone effects on plasma levels of homovanillic acid (HVA), the dopamine metabolite, in healthy volunteers...

journal_title：Biological psychiatry

authors： Posener JA,Schatzberg AF,Williams GH,Samson JA,McHale NL,Bessette MP,Schildkraut JJ

更新日期：1999-01-15 00:00:00

abstract：BACKGROUND:Survival and differentiation of neurons and the formation and maintenance of synapses in the cerebral cortex may be affected in schizophrenia. Since neurotrophins play an important role in these events, behavioral effects relevant to schizophrenia were investigated in rats that had compromised neurotrophin f...

journal_title：Biological psychiatry

authors： Rajakumar N,Leung LS,Ma J,Rajakumar B,Rushlow W

更新日期：2004-04-15 00:00:00

abstract：:The effect of oral contraceptive use and hospitalization stress on the results of the dexamethasone suppression test (DST) were assessed. This test, in which 1 mg dexamethasone is given at 11:00 p.m., and blood cortisol is analyzed the following day, is used as an indicator or major or endogenous depression, as oppos...

journal_title：Biological psychiatry

authors： D'haenen H,de Weert D,Ansseau M

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Comparing prefrontal cortical activity during particular phases of working memory in healthy subjects and individuals diagnosed with schizophrenia might help to define the phase-specific deficits in cortical function that contribute to cognitive impairments associated with schizophrenia. This study featured ...

journal_title：Biological psychiatry

authors： Driesen NR,Leung HC,Calhoun VD,Constable RT,Gueorguieva R,Hoffman R,Skudlarski P,Goldman-Rakic PS,Krystal JH

更新日期：2008-12-15 00:00:00

abstract：BACKGROUND:Disruptions of emotional information processing (i.e., attention to, memory for, and interpretation of emotional information) have been implicated in the onset and maintenance of depression. The research presented here investigated cognitive and psychophysiological features of a particularly promising correl...

journal_title：Biological psychiatry

authors： Siegle GJ,Granholm E,Ingram RE,Matt GE

更新日期：2001-04-01 00:00:00

abstract：:Autonomic characteristics of nonclinical panic and blood phobia were compared using spectral analysis of the electrocardiogram (EKG), as well as more conventional cardiovascular measures. The cardiovascular responses of 11 subjects who reported recent occurrence of frequent severe panic attacks, and 10 subjects who re...

journal_title：Biological psychiatry

authors： Friedman BH,Thayer JF,Borkovec TD,Tyrrell RA,Johnson BH,Columbo R

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Norepinephrine and dopamine mediate important aspects of alcoholism and alcohol withdrawal. Dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine. A recent study demonstrated a strong association between variance in plasma DbetaH activity and a novel polymorphism (DBH-1021C-->T) at the struc...

journal_title：Biological psychiatry

authors： Köhnke MD,Zabetian CP,Anderson GM,Kolb W,Gaertner I,Buchkremer G,Vonthein R,Schick S,Lutz U,Köhnke AM,Cubells JF

更新日期：2002-12-15 00:00:00

abstract：:This article has been retracted, consistent with Elsevier Policy on Article Withdrawal. Please see . The Publisher apologises for any inconvenience this may cause. ...

journal_title：Biological psychiatry

authors： Friedman JI,Chang L,Tsopelas N,Ernst T,Zhong K,Gorman JM,Davis KL

更新日期：2006-02-14 00:00:00

abstract：BACKGROUND:No opioid receptor, mu 1 (OPRM1) gene polymorphisms, including the functional single nucleotide polymorphism (SNP) rs1799971, have been conclusively associated with heroin/other opioid addiction, despite their biological plausibility. We used evidence of polymorphisms altering OPRM1 expression in normal huma...

journal_title：Biological psychiatry

authors： Hancock DB,Levy JL,Gaddis NC,Glasheen C,Saccone NL,Page GP,Hulse GK,Wildenauer D,Kelty EA,Schwab SG,Degenhardt L,Martin NG,Montgomery GW,Attia J,Holliday EG,McEvoy M,Scott RJ,Bierut LJ,Nelson EC,Kral AH,Johnson EO

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:There is evidence that dysfunction within associative frontostriatal circuits represents a feature of obsessive-compulsive disorder (OCD). Previous neuropsychologic studies have yielded diverging results, which may in part be explained by differences in the selection of subjects and methods. The present stud...

journal_title：Biological psychiatry

authors： Schmidtke K,Schorb A,Winkelmann G,Hohagen F

更新日期：1998-05-01 00:00:00