当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Allelic variation in the serotonin transporter promoter modulates cortical excitability.

Allelic variation in the serotonin transporter promoter modulates cortical excitability.

Abstract：

BACKGROUND:Transcranial magnetic stimulation (TMS) is a noninvasive procedure that may be used to study individual differences in motor cortex excitability. Such differences are assumed to reflect serotonergic and other inputs to the motor cortex. METHODS:Here we investigate the impact of a functional polymorphism in the promoter region of the 5-hydroxytryptamine transporter gene (5-HTTLPR) on measures of motor cortex excitability. RESULTS:Sixty healthy subjects carrying one or two copies of the short 5-HTTLPR allele (s/s and s/l) showed a significant reduction in short intracortical inhibition (SICI, p = .012) and an increased cortical silent period (p = .042) compared with 60 age- and sex-matched individuals homozygous for the long allele (l/l). In contrast, motor threshold and intracortical facilitation did not differ significantly between groups. CONCLUSIONS:These results provide further evidence of a role for serotonergic transmission in the modulation of cortical excitability. Differential effects on the measures under study suggest a pattern of prioritization in bioamine regulation of cortical inhibition.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Langguth B,Sand P,Marek R,Landgrebe M,Frank E,Hajak G,Eichhammer P

doi

10.1016/j.biopsych.2009.02.005

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

283-6

issue

3

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(09)00189-9

journal_volume

66

pub_type

杂志文章,收录出版

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Involvement of the limbic system in multiple sclerosis patients with depressive disorders.

    abstract：:This study investigates the relationship between depression and both anatomic and cerebral blood flow abnormalities in multiple sclerosis (MS) patients. Ten nondepressed MS patients were compared with 10 depressed MS patients matched for age, sex, and functional disability. Both groups were evaluated by means of neuro...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0006-3223(95)00291-x

    authors： Sabatini U,Pozzilli C,Pantano P,Koudriavtseva T,Padovani A,Millefiorini E,Di Biasi C,Gualdi GF,Salvetti M,Lenzi GL

    更新日期：1996-06-01 00:00:00

  • Acute depressed mood as a trigger of acute coronary syndromes.

    abstract：BACKGROUND:Some cases of acute coronary syndrome (ACS) may be triggered by emotional states such as anger, but it is not known if acute depressed mood can act as a trigger. METHODS:295 men and women with a verified ACS were studied. Depressed mood in the two hours before ACS symptom onset was compared with the same pe...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.03.041

    authors： Steptoe A,Strike PC,Perkins-Porras L,McEwan JR,Whitehead DL

    更新日期：2006-10-15 00:00:00

  • "Normal" personality correlates of sensorimotor, cognitive, and visuospatial gating.

    abstract：:Specific psychiatric disorders are characterized by impaired selective inhibition or "gating" of responses to sensory or cognitive information. Less is known about gating differences among normal individuals. We tested carefully screened controls in measures of central inhibition: prepulse inhibition (PPI) of startle,...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(94)00138-S

    authors： Swerdlow NR,Filion D,Geyer MA,Braff DL

    更新日期：1995-03-01 00:00:00

  • Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating.

    abstract：BACKGROUND:Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop th...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2016.12.025

    authors： Bronson SL,Chan JC,Bale TL

    更新日期：2017-07-15 00:00:00

  • The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder.

    abstract：BACKGROUND:Autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are associated with complex changes as revealed by functional magnetic resonance imaging. To date, neuroimaging-based models are not able to characterize individuals with sufficient sensitivity and specificity. Further, although evi...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2019.02.019

    authors： Lake EMR,Finn ES,Noble SM,Vanderwal T,Shen X,Rosenberg MD,Spann MN,Chun MM,Scheinost D,Constable RT

    更新日期：2019-08-15 00:00:00

  • Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.

    abstract：BACKGROUND:Antenatal maternal cortisol levels associate with alterations in the amygdala, a structure associated with emotion regulation, in the offspring. However, because offspring brain and behavior are commonly assessed years after birth, the timing of such maternal influences is unclear. This study aimed to examin...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.06.019

    authors： Rifkin-Graboi A,Bai J,Chen H,Hameed WB,Sim LW,Tint MT,Leutscher-Broekman B,Chong YS,Gluckman PD,Fortier MV,Meaney MJ,Qiu A

    更新日期：2013-12-01 00:00:00

  • Flavor-independent maintenance, extinction, and reinstatement of fat self-administration in mice.

    abstract：BACKGROUND:Mounting evidence suggests that overeating may be conceptualized within the same behavioral and neurobiological framework as drug addiction. One potentially important difference between overeating versus drug abuse refers to the sensory stimulation of oral receptors by palatable foods, a feature that may be ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.02.028

    authors： Tellez LA,Ferreira JG,Medina S,Land BB,DiLeone RJ,de Araujo IE

    更新日期：2013-05-01 00:00:00

  • Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions.

    abstract：:Posttraumatic stress disorder (PTSD) is a stress-related psychiatric disorder that is thought to emerge from complex interactions among traumatic events and multiple genetic factors. Epigenetic regulation lies at the heart of these interactions and mediates the lasting effects of the environment on gene regulation. An...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2015.04.003

    authors： Zannas AS,Provençal N,Binder EB

    更新日期：2015-09-01 00:00:00

  • Catecholamines in the bed nucleus of the stria terminalis reciprocally respond to reward and aversion.

    abstract：BACKGROUND:Traditionally, norepinephrine has been associated with stress responses, whereas dopamine has been associated with reward. Both of these catecholamines are found within the bed nucleus of the stria terminalis (BNST), a brain relay nucleus in the extended amygdala between cortical/limbic centers, and the hypo...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.10.017

    authors： Park J,Wheeler RA,Fontillas K,Keithley RB,Carelli RM,Wightman RM

    更新日期：2012-02-15 00:00:00

  • HLA antigens in schizophrenia and mood disorders.

    abstract：:The frequencies of HLA antigens were examined in a sample of 75 patients with schizophrenia and 35 patients with mood disorders. We compared the data obtained from this population with data obtained in another study with 3731 healthy subjects. Statistically significant increases were observed in the frequencies of HLA...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(95)00223-5

    authors： Ozcan ME,Taskin R,Banoglu R,Babacan M,Tuncer E

    更新日期：1996-05-15 00:00:00

  • An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression.

    abstract：BACKGROUND:Preclinical and clinical evidence indicate that the glutamatergic system might play a role in the pathophysiology of mood disorders. This study was conducted to determine the efficacy and safety of riluzole, a glutamate-modulating agent, in bipolar depression. METHODS:This was an 8-week add-on study of rilu...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.biopsych.2004.11.023

    authors： Zarate CA Jr,Quiroz JA,Singh JB,Denicoff KD,De Jesus G,Luckenbaugh DA,Charney DS,Manji HK

    更新日期：2005-02-15 00:00:00

  • Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder.

    abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) is a common and severe psychiatric illness that affects 1-3% of the population and presents a well-established co-morbidity with major depressive disorder (MDD). Twin and family studies have suggested a genetic component in the etiology of OCD, although the mode of inherit...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00319-9

    authors： Karayiorgou M,Sobin C,Blundell ML,Galke BL,Malinova L,Goldberg P,Ott J,Gogos JA

    更新日期：1999-05-01 00:00:00

  • Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk.

    abstract：BACKGROUND:The implication of serotonin in suicide and affective disease explains why the 5-HT(2A) receptor gene has been proposed as a candidate gene in these disorders, although with conflicting results. METHODS:We analysed the distribution of the 5-HT(2A)-1438A/G genetic polymorphism in 192 patients with major affe...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(01)01228-8

    authors： Bonnier B,Gorwood P,Hamon M,Sarfati Y,Boni C,Hardy-Bayle MC

    更新日期：2002-05-01 00:00:00

  • Activity-Regulated Cytoskeleton-Associated Protein Accumulates in the Nucleus in Response to Cocaine and Acts as a Brake on Chromatin Remodeling and Long-Term Behavioral Alterations.

    abstract：BACKGROUND:Addiction relies on persistent alterations of neuronal properties, which depends on gene regulation. Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying learning and memory. Its role in cocaine-induced neuronal and behavioral adapt...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2016.05.025

    authors： Salery M,Dos Santos M,Saint-Jour E,Moumné L,Pagès C,Kappès V,Parnaudeau S,Caboche J,Vanhoutte P

    更新日期：2017-04-01 00:00:00

  • Neural Mechanisms of Early-Life Social Stress as a Developmental Risk Factor for Severe Psychiatric Disorders.

    abstract：BACKGROUND:To explore the domain-general risk factor of early-life social stress in mental illness, rearing rodents in persistent postweaning social isolation has been established as a widely used animal model with translational relevance for neurodevelopmental psychiatric disorders such as schizophrenia. Although chan...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2017.12.010

    authors： Reinwald JR,Becker R,Mallien AS,Falfan-Melgoza C,Sack M,Clemm von Hohenberg C,Braun U,Cosa Linan A,Gass N,Vasilescu AN,Tollens F,Lebhardt P,Pfeiffer N,Inta D,Meyer-Lindenberg A,Gass P,Sartorius A,Weber-Fahr W

    更新日期：2018-07-15 00:00:00

  • Lymphocyte subset, lymphocyte proliferative response, and soluble interleukin-2 receptor in anorexic patients.

    abstract：BACKGROUND:Despite a prominent malnourished state, anorexics are unexpectedly free from infection. Several studies have shown that the cell-mediated immunity of anorexics might be well preserved, but results are conflicting. METHODS:Lymphocyte subsets, lymphoproliferative response to phytohemagglutinin, and soluble in...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00082-1

    authors： Nagata T,Kiriike N,Tobitani W,Kawarada Y,Matsunaga H,Yamagami S

    更新日期：1999-02-15 00:00:00

  • Circadian patterns of cortisol, prolactin, and growth hormonal secretion during bingeing and vomiting in normal weight bulimic patients.

    abstract：:Women who are of normal weight and have bulimia nervosa exhibit multiple neuroendocrine disturbances. We hypothesized that bingeing and vomiting behavior could be contributory because food consumption in healthy volunteers increases plasma cortisol and prolactin secretion and suppresses growth hormone secretion. Thus,...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90068-w

    authors： Weltzin TE,McConaha C,McKee M,Hsu LK,Perel J,Kaye WH

    更新日期：1991-07-01 00:00:00

  • Event-related potential correlates of impaired selective attention in children at high risk for schizophrenia.

    abstract：:Auditory event-related potentials (ERPs) associated with selective attention were recorded in 21 children at high-risk for schizophrenia and in 21 matched controls. The subjects performed a selective listening task. For behavioral evaluation, target counts on the selective listening task and on cognitive performance w...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90294-a

    authors： Schreiber H,Stolz-Born G,Kornhuber HH,Born J

    更新日期：1992-10-15 00:00:00

  • Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial.

    abstract：BACKGROUND:Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy. METHODS:This 10-week, acute, randomized, controlled, masked trial compared adjunc...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2005.05.025

    authors： Rush AJ,Marangell LB,Sackeim HA,George MS,Brannan SK,Davis SM,Howland R,Kling MA,Rittberg BR,Burke WJ,Rapaport MH,Zajecka J,Nierenberg AA,Husain MM,Ginsberg D,Cooke RG

    更新日期：2005-09-01 00:00:00

  • Sensory gating in schizophrenia: P50 and N100 gating in antipsychotic-free subjects at risk, first-episode, and chronic patients.

    abstract：BACKGROUND:Abnormal sensory gating in schizophrenia has frequently been reported; however, only limited data on unmedicated patients and patients at risk to develop a psychosis have, as yet, been available. METHODS:P50 and N100 suppression were assessed with an auditory double-click paradigm in five groups: 18 at-risk...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.02.006

    authors： Brockhaus-Dumke A,Schultze-Lutter F,Mueller R,Tendolkar I,Bechdolf A,Pukrop R,Klosterkoetter J,Ruhrmann S

    更新日期：2008-09-01 00:00:00

  • Skin conductance activity after intraventricular administration of 6-hydroxydopa in rats.

    abstract：:Absence of skin conductance response (SCR) and failure of its habituation are psychophysiological signs observed in most schizophrenics. In the present experiments, skin conductance activity was studied in rats before and after intraventricular administration of 6-hydroxydopa (6-OHdopa), a neurotoxin that selectively ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90222-8

    authors： Yamamoto K,Hoshino T,Takahashi Y,Kaneko H,Ozawa N

    更新日期：1991-02-15 00:00:00

  • Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.

    abstract：BACKGROUND:Endocytic dysfunction and neurotrophin signaling deficits may underlie the selective vulnerability of hippocampal neurons during the progression of Alzheimer's disease (AD), although there is little direct in vivo and biochemical evidence to support this hypothesis. METHODS:Microarray analysis of hippocampa...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.05.030

    authors： Ginsberg SD,Alldred MJ,Counts SE,Cataldo AM,Neve RL,Jiang Y,Wuu J,Chao MV,Mufson EJ,Nixon RA,Che S

    更新日期：2010-11-15 00:00:00

  • Quantitative, waking EEG research on depression.

    abstract：:Research published in the past decade that used quantitative indices to evaluate the waking EEG characteristics of depressed patients is reviewed. Methodological problems that make results of different research laboratories difficult to compare include diagnostic heterogeneity of depressed groups, lack of inclusion of...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0006-3223(90)90591-o

    authors： Pollock VE,Schneider LS

    更新日期：1990-04-01 00:00:00

  • Adrenocortical function and plasma norepinephrine in normal human subjects.

    abstract：:Abnormal adrenocortical regulation has been reported in patients with endogenous depression, including excessive cortisol production with loss of circadian periodicity and decreased suppression by dexamethasone. The inhibitory effect of the neurotransmitter norepinephrine (NE) on the hypothalamic-pituitary adrenal (HP...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Sotsky SM,Lake CR,Goodwin FK

    更新日期：1981-07-01 00:00:00

  • Neural changes associated with treatment outcome in children with externalizing problems.

    abstract：BACKGROUND:The current study directly investigated whether changes in the neural correlates of self-regulation (SR) are associated with the effectiveness of treatment for the externalizing problems of children. METHODS:Seventy-one children 8-12 years of age with clinical levels of externalizing behavior and their fami...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.05.029

    authors： Woltering S,Granic I,Lamm C,Lewis MD

    更新日期：2011-11-01 00:00:00

  • Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence.

    abstract：BACKGROUND:Intimate partner violence (IPV) is one of the most common causes of posttraumatic stress disorder (PTSD) in women. Women with IPV-related PTSD often experience comorbid chronic pain and pain-related disability. Despite the high comorbidity between PTSD and chronic pain, recent evidence suggests that male vet...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.03.034

    authors： Strigo IA,Simmons AN,Matthews SC,Grimes EM,Allard CB,Reinhardt LE,Paulus MP,Stein MB

    更新日期：2010-09-01 00:00:00

  • Multivariate analyses of the EEG in normal adolescents.

    abstract：:We investigated the computerized electroencephalography (cEEG) in a group of 85 normal adolescents. The spatial frequency of the cEEG was analyzed using various multivariate statistical techniques. The factor analyses revealed three factors that accounted for most of the variability in the data and that could be inter...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(87)90231-9

    authors： Volkow ND,Gomez-Mont F,Inamdar S,Lamella M,Prichep L,John R

    更新日期：1987-02-01 00:00:00

  • A double-blind trial of carbamazepine in negative symptom schizophrenia.

    abstract：:Twenty-eight residual schizophrenics hospitalized in a chronic institution with a 9 to 30 year history of disease, with predominantly negative symptoms were given carbamazepine. Carbamazepine was administered in a double-blind trial and therapeutic effects were measured by the Scale for the Assessment of Negative Symp...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0006-3223(94)91162-2

    authors： Nachshoni T,Levin Y,Levy A,Kritz A,Neumann M

    更新日期：1994-01-01 00:00:00

  • Reduced cerebrospinal fluid dynorphin A1-8 in Alzheimer's disease.

    abstract：:Cerebrospinal fluid (CSF) measures of dynorphin A were compared in three groups. Alzheimer patients (n = 9), elderly depressives (n = 9), and age-matched normal controls (n = 9). The Alzheimer patients revealed a 40% decrease in CSF dynorphin compared with controls (36 +/- 15 versus 60 +/- 21 pg/ml, p less than 0.05)....

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90073-u

    authors： Sunderland T,Berrettini WH,Molchan SE,Lawlor BA,Martinez RA,Vitiello B,Tariot PN,Cohen RM

    更新日期：1991-07-01 00:00:00

  • Depressive symptoms are associated with soluble P-selectin reactivity to acute exercise in heart failure.

    abstract：BACKGROUND:To determine the effects of depressive symptom severity on the circulating soluble adhesion molecule response to an acute exercise challenge in patients with heart failure (HF) compared with control subjects. METHODS:Thirty-eight male HF patients and 19 male control subjects (mean age +/- SEM: 55.5 +/- 1.9)...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.11.013

    authors： Wirtz PH,Hong S,Redwine LS,Tafur J,Rutledge T,Ziegler MG,Greenberg B,Mills PJ

    更新日期：2009-05-01 00:00:00