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An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression.

Abstract：

BACKGROUND:Preclinical and clinical evidence indicate that the glutamatergic system might play a role in the pathophysiology of mood disorders. This study was conducted to determine the efficacy and safety of riluzole, a glutamate-modulating agent, in bipolar depression. METHODS:This was an 8-week add-on study of riluzole in combination with lithium in acutely depressed bipolar patients aged 18 years and older. After open treatment with lithium for a minimum period of 4 weeks, subjects who continued to have a Montgomery-Asberg Depression Rating Scale (MADRS) score of >/=20 received riluzole (50-200 mg/day) for 8 weeks. RESULTS:Fourteen bipolar depressed patients entered the study. The linear mixed models for total MADRS score showed a significant treatment effect. No switch into hypomania or mania was observed. Overall, riluzole was well tolerated. CONCLUSIONS:Although preliminary, these results suggest that riluzole might indeed have antidepressant efficacy in subjects with bipolar depression.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Zarate CA Jr,Quiroz JA,Singh JB,Denicoff KD,De Jesus G,Luckenbaugh DA,Charney DS,Manji HK

doi

10.1016/j.biopsych.2004.11.023

subject

Has Abstract

pub_date

2005-02-15 00:00:00

pages

430-2

issue

4

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(04)01225-9

journal_volume

57

pub_type

临床试验,杂志文章

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