Abstract:
BACKGROUND:The current study directly investigated whether changes in the neural correlates of self-regulation (SR) are associated with the effectiveness of treatment for the externalizing problems of children. METHODS:Seventy-one children 8-12 years of age with clinical levels of externalizing behavior and their families completed a 3-month cognitive behavioral therapy program with a parent management training component. Electroencephalogram correlates of SR were evaluated before and after treatment with a go/no-go task requiring inhibitory control. RESULTS:Results showed that neural markers of SR, such as the N2 and frontal P3 event-related potential magnitudes, differed between the clinical sample and a matched comparison group before treatment: the clinical sample had larger N2 magnitudes and smaller frontal P3 magnitudes. Children who improved with treatment demonstrated a marked decrease in the magnitude of the N2 in comparison with children who did not improve. For improvers only, source analyses during the time period of the N2 estimated activation decreases in medial and ventral prefrontal cortex as well as the anterior medial temporal lobe. CONCLUSIONS:A decrease in N2 magnitudes and corresponding source activation in children who improved with treatment might reflect improved efficiency in the neural mechanisms of SR.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Woltering S,Granic I,Lamm C,Lewis MDdoi
10.1016/j.biopsych.2011.05.029subject
Has Abstractpub_date
2011-11-01 00:00:00pages
873-9issue
9eissn
0006-3223issn
1873-2402pii
S0006-3223(11)00589-0journal_volume
70pub_type
杂志文章abstract:BACKGROUND:Traumatic experiences for young children might result in profound neurodevelopmental changes, compared with adults. Our aim was to examine autonomic control of heart rate in traumatized young children. METHODS:Sixty-two children who had suffered traumas and 62 nontraumatized control children, aged 20 months...
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pub_type: 杂志文章,随机对照试验
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abstract::Delirium, also known as acute confusional state, is a common reversible organic psychiatric syndrome. This paper focuses on toxic delirium associated with prominent paroxysmal electroencephalogram (EEG) dysfunction occurring in nonepileptic patients. Our data derive from observations in two conditions, viz., delirium ...
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abstract:BACKGROUND:Although neuropsychological and neuroimaging studies of obsessive-compulsive disorder (OCD) have implicated the frontal cortex and subcortical structures in the pathophysiology of the disorder, few studies have examined cognitive function in patients with OCD on tasks validated in the assessment of frontal l...
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pub_type: 杂志文章,多中心研究
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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更新日期:1996-04-15 00:00:00
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2010.09.005
更新日期:2011-02-15 00:00:00
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更新日期:2002-07-15 00:00:00
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更新日期:2017-02-01 00:00:00
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doi:10.1016/j.biopsych.2015.07.015
更新日期:2016-05-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2005.06.027
更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2003.11.002
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(95)00430-0
更新日期:1996-09-15 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-16 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.10.045
更新日期:2009-06-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2005.11.010
更新日期:2006-09-01 00:00:00
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更新日期:2001-03-15 00:00:00
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pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.05.008
更新日期:2009-11-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2010.07.009
更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(00)01101-x
更新日期:2001-02-01 00:00:00