Neural changes associated with treatment outcome in children with externalizing problems.

Abstract:

BACKGROUND:The current study directly investigated whether changes in the neural correlates of self-regulation (SR) are associated with the effectiveness of treatment for the externalizing problems of children. METHODS:Seventy-one children 8-12 years of age with clinical levels of externalizing behavior and their families completed a 3-month cognitive behavioral therapy program with a parent management training component. Electroencephalogram correlates of SR were evaluated before and after treatment with a go/no-go task requiring inhibitory control. RESULTS:Results showed that neural markers of SR, such as the N2 and frontal P3 event-related potential magnitudes, differed between the clinical sample and a matched comparison group before treatment: the clinical sample had larger N2 magnitudes and smaller frontal P3 magnitudes. Children who improved with treatment demonstrated a marked decrease in the magnitude of the N2 in comparison with children who did not improve. For improvers only, source analyses during the time period of the N2 estimated activation decreases in medial and ventral prefrontal cortex as well as the anterior medial temporal lobe. CONCLUSIONS:A decrease in N2 magnitudes and corresponding source activation in children who improved with treatment might reflect improved efficiency in the neural mechanisms of SR.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Woltering S,Granic I,Lamm C,Lewis MD

doi

10.1016/j.biopsych.2011.05.029

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

873-9

issue

9

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(11)00589-0

journal_volume

70

pub_type

杂志文章
  • Heart period and variability findings in preschool children with posttraumatic stress symptoms.

    abstract:BACKGROUND:Traumatic experiences for young children might result in profound neurodevelopmental changes, compared with adults. Our aim was to examine autonomic control of heart rate in traumatized young children. METHODS:Sixty-two children who had suffered traumas and 62 nontraumatized control children, aged 20 months...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2004.01.006

    authors: Scheeringa MS,Zeanah CH,Myers L,Putnam F

    更新日期:2004-04-01 00:00:00

  • Nicotine fails to attenuate ketamine-induced cognitive deficits and negative and positive symptoms in humans: implications for schizophrenia.

    abstract:BACKGROUND:The uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist, ketamine, induces a range of symptoms resembling those seen in schizophrenia. Enhancement of nicotinic acetylcholine receptor (nAChR) function may have potential as a treatment for the cognitive deficits and negative symptoms of schizophreni...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.biopsych.2012.05.009

    authors: D'Souza DC,Ahn K,Bhakta S,Elander J,Singh N,Nadim H,Jatlow P,Suckow RF,Pittman B,Ranganathan M

    更新日期:2012-11-01 00:00:00

  • Toxic ictal delirium.

    abstract::Delirium, also known as acute confusional state, is a common reversible organic psychiatric syndrome. This paper focuses on toxic delirium associated with prominent paroxysmal electroencephalogram (EEG) dysfunction occurring in nonepileptic patients. Our data derive from observations in two conditions, viz., delirium ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(89)90198-4

    authors: van Sweden B,Mellerio F

    更新日期:1989-02-15 00:00:00

  • Asterixis induced by carbamazepine therapy.

    abstract::There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents. In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(92)90040-7

    authors: Rittmannsberger H,Leblhuber F

    更新日期:1992-08-15 00:00:00

  • Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function.

    abstract:BACKGROUND:Although neuropsychological and neuroimaging studies of obsessive-compulsive disorder (OCD) have implicated the frontal cortex and subcortical structures in the pathophysiology of the disorder, few studies have examined cognitive function in patients with OCD on tasks validated in the assessment of frontal l...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0006-3223(97)00201-1

    authors: Purcell R,Maruff P,Kyrios M,Pantelis C

    更新日期:1998-03-01 00:00:00

  • Attentional Bias Predicts Increased Reward Salience and Risk Taking in Bipolar Disorder.

    abstract:BACKGROUND:There is amassing evidence that risky decision-making in bipolar disorder is related to reward-based differences in frontostriatal regions. However, the roles of early attentional and later cognitive processes remain unclear, limiting theoretical understanding and development of targeted interventions. METH...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2015.03.014

    authors: Mason L,Trujillo-Barreto NJ,Bentall RP,El-Deredy W

    更新日期:2016-02-15 00:00:00

  • Event-related potentials in adolescents with schizophrenia and their siblings: a comparison with attention-deficit/hyperactivity disorder.

    abstract:BACKGROUND:Identifying trait markers specific to schizophrenia might uncover mechanisms underlying illness susceptibility. Previous research shows the N2 and P3 event-related potentials are abnormal in schizophrenia; specificity of these potential trait markers has not been well established. METHODS:Electroencephalogr...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.biopsych.2007.09.018

    authors: Groom MJ,Bates AT,Jackson GM,Calton TG,Liddle PF,Hollis C

    更新日期:2008-04-15 00:00:00

  • Borderline personality, impulsiveness, and platelet monoamine measures in bulimia nervosa and recurrent suicidal behavior.

    abstract::This study examined the relationship between borderline and impulsive personality traits on the one hand, and monoamine function on the other in 15 women with bulimia nervosa and 15 women with recurrent suicidal behavior. Platelet serotonin (5-HT) and platelet monoamine oxidase (MAO) activity were used as peripheral m...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(95)00384-3

    authors: Verkes RJ,Pijl H,Meinders AE,Van Kempen GM

    更新日期:1996-08-01 00:00:00

  • Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression.

    abstract:BACKGROUND:Maintenance treatment to prevent recurrences is recommended for chronic forms of major depressive disorder (MDD), but few studies have examined maintenance efficacy of antidepressants with chronic MDD. This randomized, placebo-controlled study of the efficacy and safety of nefazodone in preventing recurrence...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0006-3223(02)01971-6

    authors: Gelenberg AJ,Trivedi MH,Rush AJ,Thase ME,Howland R,Klein DN,Kornstein SG,Dunner DL,Markowitz JC,Hirschfeld RM,Keitner GI,Zajecka J,Kocsis JH,Russell JM,Miller I,Manber R,Arnow B,Rothbaum B,Munsaka M,Banks P,Borian

    更新日期:2003-10-15 00:00:00

  • Pretreatment brain states identify likely nonresponse to standard treatments for depression.

    abstract:BACKGROUND:Treatment approaches for major depressive disorder (MDD) result in approximately one third of patients achieving remission after a first treatment. Added treatment generally improves remission rates, but approximately one third of all patients fail to respond after several treatments (sequential monotherapie...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.biopsych.2013.12.005

    authors: McGrath CL,Kelley ME,Dunlop BW,Holtzheimer PE 3rd,Craighead WE,Mayberg HS

    更新日期:2014-10-01 00:00:00

  • Electrophysiological findings during the menstrual cycle in women with and without late luteal phase dysphoric disorder: relationship to risk for alcoholism?

    abstract::This study evaluated electrophysiological (EEG, ERGs), and cognitive (neuropsychological testing) responses in patients with late luteal phase dysphoric disorder (LLPDD, DSM-III-R) and controls over the menstrual cycle. In both groups, the frequency and stability of electroencephalogram (EEG) alpha activity significan...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/0006-3223(95)00183-2

    authors: Ehlers CL,Phillips E,Parry BL

    更新日期:1996-04-15 00:00:00

  • Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder.

    abstract:BACKGROUND:The hippocampus (HC) is smaller in patients with recurrent major depressive disorder (MDD), but few longitudinal studies have examined whether volume is associated with clinically meaningful outcomes such as response to treatment. METHODS:We compared regional (head and body/tail) HC volumes in 46 patients w...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2008.06.027

    authors: MacQueen GM,Yucel K,Taylor VH,Macdonald K,Joffe R

    更新日期:2008-11-15 00:00:00

  • Dimensions of depression and anxiety and the hypothalamo-pituitary-adrenal axis.

    abstract:BACKGROUND:Results on the association between depression and the hypothalamo-pituitary-adrenal (HPA) axis have been inconsistent, possibly due to heterogeneity of the DSM-IV category of depression. Specific symptom-dimensions could be used as a more homogenous phenotype in HPA-axis research. METHODS:Subjects (n = 1029...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2010.09.005

    authors: Wardenaar KJ,Vreeburg SA,van Veen T,Giltay EJ,Veen G,Penninx BW,Zitman FG

    更新日期:2011-02-15 00:00:00

  • Regional prefrontal gray and white matter abnormalities in bipolar disorder.

    abstract:BACKGROUND:Previous magnetic resonance imaging (MRI) studies indicate that compared with healthy volunteers, patients with bipolar disorder have structural and functional abnormalities in the prefrontal cortex. The aim of this study was to investigate differences in prefrontal subregions between bipolar patients and he...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(02)01350-1

    authors: López-Larson MP,DelBello MP,Zimmerman ME,Schwiers ML,Strakowski SM

    更新日期:2002-07-15 00:00:00

  • Impaired Communication Between the Motor and Somatosensory Homunculus Is Associated With Poor Manual Dexterity in Autism Spectrum Disorder.

    abstract:BACKGROUND:Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting quality of life. Sensory inputs reaching the primary motor cortex (M1) from the somatosensory cortex (S1) are likely involved in fine motor skill and specifically motor learning. However, the role of these conn...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2016.06.020

    authors: Thompson A,Murphy D,Dell'Acqua F,Ecker C,McAlonan G,Howells H,Baron-Cohen S,Lai MC,Lombardo MV,MRC AIMS Consortium, and Marco Catani.

    更新日期:2017-02-01 00:00:00

  • Trajectory and Predictors of Depression and Anxiety Disorders in Mothers With the FMR1 Premutation.

    abstract:BACKGROUND:Although the FMR1 premutation is associated with elevated prevalence of psychiatric disorders, the longitudinal course of symptoms has not been established. The present study followed a sample of women with the FMR1 premutation to characterize the incidence, stability, and predictors of mood and anxiety diso...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2015.07.015

    authors: Roberts JE,Tonnsen BL,McCary LM,Ford AL,Golden RN,Bailey DB Jr

    更新日期:2016-05-15 00:00:00

  • Use of bupropion in combination with serotonin reuptake inhibitors.

    abstract::Incomplete symptom remission and sexual side effects are common problems for which bupropion often is added to treatment with selective serotonin and serotonin-norepinephrine reuptake inhibitors (SSRIs and SNRIs) for patients with major depressive disorder (MDD). This article reviews the literature on combining buprop...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.biopsych.2005.06.027

    authors: Zisook S,Rush AJ,Haight BR,Clines DC,Rockett CB

    更新日期:2006-02-01 00:00:00

  • Support for RGS4 as a susceptibility gene for schizophrenia.

    abstract:BACKGROUND:The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2003.11.002

    authors: Williams NM,Preece A,Spurlock G,Norton N,Williams HJ,McCreadie RG,Buckland P,Sharkey V,Chowdari KV,Zammit S,Nimgaonkar V,Kirov G,Owen MJ,O'Donovan MC

    更新日期:2004-01-15 00:00:00

  • Induction of tetradecanoyl phorbol acetate-inducible sequence (TIS) genes by electroconvulsive shock in rat brain.

    abstract::We studied the induction of tetradecanoyl phorbol acetate-inducible sequences (TIS)1, 7, 8, 11, and 21 in rat cerebral cortex, hippocampus, and cerebellum after electroconvulsive shock (ECS). These genes were reported to be induced by depolarization in PC-12 cells. Single ECS induced TIS1, 8, 11, and 21, but not TIS7 ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(95)00430-0

    authors: Jung HY,Kang UG,Ahn YM,Joo YH,Park JB,Kim YS

    更新日期:1996-09-15 00:00:00

  • Cortex, white matter, and basal ganglia in schizophrenia: a volumetric postmortem study.

    abstract::Postmortem volumetry of cortex, white matter, and basal ganglia was performed in 23 brains of schizophrenic patients and 23 brains of controls closely matched for gender, age, and hemisphere. Stereological methods were applied to serial coronal sections of complete hemispheres. We found no significant volume changes o...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(91)90091-y

    authors: Heckers S,Heinsen H,Heinsen Y,Beckmann H

    更新日期:1991-03-15 00:00:00

  • Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa.

    abstract:BACKGROUND:Increased physical activity is a common feature of anorexia nervosa (AN). Although high activity levels are associated with greater risk of developing AN, particularly when combined with dieting, most individuals who diet and exercise maintain a healthy body weight. It is unclear why some individuals develop...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2020.06.030

    authors: Beeler JA,Mourra D,Zanca RM,Kalmbach A,Gellman C,Klein BY,Ravenelle R,Serrano P,Moore H,Rayport S,Mingote S,Burghardt NS

    更新日期:2020-07-16 00:00:00

  • Is persistent ketamine use a valid model of the cognitive and oculomotor deficits in schizophrenia?

    abstract:BACKGROUND:Acute ketamine has been shown to model features of schizophrenia such as psychotic symptoms, cognitive deficits and smooth pursuit eye movement dysfunction. There have been suggestions that chronic ketamine may also produce an analogue of the disorder. In this study, we investigated the effect of persistent ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2008.10.045

    authors: Morgan CJ,Huddy V,Lipton M,Curran HV,Joyce EM

    更新日期:2009-06-15 00:00:00

  • The neuropsychological profile of psychotic major depression and its relation to cortisol.

    abstract:BACKGROUND:Our study described the neuropsychological profile of psychotic major depression (PMD) compared to nonpsychotic major depression (NPMD) patients and psychiatrically healthy controls (HC). We predicted that higher cortisol levels would be associated with greater cognitive deficits. METHODS:Twenty-nine PMDs, ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2005.11.010

    authors: Gomez RG,Fleming SH,Keller J,Flores B,Kenna H,DeBattista C,Solvason B,Schatzberg AF

    更新日期:2006-09-01 00:00:00

  • Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer's disease.

    abstract:BACKGROUND:Abnormalities at several levels of the hypothalamic-pituitary-adrenal axis, which may promote glucocorticoid dependent neurodegeneration, have been reported in patients with Alzheimer's disease. In this study we have explored the possibility that peripheral cortisol metabolism is enhanced and glucocorticoid ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(00)01015-5

    authors: Rasmuson S,Andrew R,Näsman B,Seckl JR,Walker BR,Olsson T

    更新日期:2001-03-15 00:00:00

  • Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder.

    abstract:BACKGROUND:Hyperactivity of the anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been shown to increase with symptom provocation and to normalize with treatment-induced symptom reduction. Although the functional significance of anterior cingulate involvement in OCD remains unknow...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2004.10.038

    authors: Fitzgerald KD,Welsh RC,Gehring WJ,Abelson JL,Himle JA,Liberzon I,Taylor SF

    更新日期:2005-02-01 00:00:00

  • Autism and nonsyndromic mental retardation associated with a de novo mutation in the NLGN4X gene promoter causing an increased expression level.

    abstract:BACKGROUND:Pathogenic mutations in the X-linked Neuroligin 4 gene (NLGN4X) in autism spectrum disorders (ASDs) and/or mental retardation (MR) are rare. However, nothing is known regarding a possible altered expression level of NLGN4X that would be caused by mutations in regulatory sequences. We investigated this issue ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2009.05.008

    authors: Daoud H,Bonnet-Brilhault F,Védrine S,Demattéi MV,Vourc'h P,Bayou N,Andres CR,Barthélémy C,Laumonnier F,Briault S

    更新日期:2009-11-15 00:00:00

  • In search of multimodal neuroimaging biomarkers of cognitive deficits in schizophrenia.

    abstract:BACKGROUND:The cognitive deficits of schizophrenia are largely resistant to current treatments and thus are a lifelong illness burden. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) provides a reliable and valid assessment of cognition across ma...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2015.02.017

    authors: Sui J,Pearlson GD,Du Y,Yu Q,Jones TR,Chen J,Jiang T,Bustillo J,Calhoun VD

    更新日期:2015-12-01 00:00:00

  • Dopamine uptake by platelet storage granules in first-degree relatives of Tourette's syndrome patients.

    abstract:BACKGROUND:Considering that platelets have been established to be good peripheral markers for the study of catecholaminergic neurons, we have applied an assay to measure the uptake of (3H)-dopamine (DA) into platelet storage granules (PSG). Recently, we reported that Tourette's syndrome (TS) patients (pts) show decreas...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(97)00476-9

    authors: Rabey JM,Amir I,Treves TA,Oberman Z,Korczyn AD

    更新日期:1998-12-01 00:00:00

  • Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.

    abstract:BACKGROUND:Recent findings indicate that inhibitors of fatty acid amide hydrolase (FAAH) counteract the rewarding effects of nicotine in rats. Inhibition of FAAH increases levels of several endogenous substances in the brain, including the endocannabinoid anandamide and the noncannabinoid fatty acid ethanolamides oleoy...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2010.07.009

    authors: Mascia P,Pistis M,Justinova Z,Panlilio LV,Luchicchi A,Lecca S,Scherma M,Fratta W,Fadda P,Barnes C,Redhi GH,Yasar S,Le Foll B,Tanda G,Piomelli D,Goldberg SR

    更新日期:2011-04-01 00:00:00

  • Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease.

    abstract::Despite the proven efficacy of acetylcholinesterase inhibitors in Alzheimer's disease, there is a need for new and more effective treatments. Galantamine is a novel treatment for Alzheimer's disease that inhibits acetylcholinesterase and modulates nicotinic receptors. In randomized, double-blind, placebo-controlled st...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/s0006-3223(00)01101-x

    authors: Coyle J,Kershaw P

    更新日期:2001-02-01 00:00:00