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Lymphocyte subset, lymphocyte proliferative response, and soluble interleukin-2 receptor in anorexic patients.

Abstract：

BACKGROUND:Despite a prominent malnourished state, anorexics are unexpectedly free from infection. Several studies have shown that the cell-mediated immunity of anorexics might be well preserved, but results are conflicting. METHODS:Lymphocyte subsets, lymphoproliferative response to phytohemagglutinin, and soluble interleukin-2 receptor (sIL-2R) were measured in 7 patients with anorexia nervosa restricting type (RAN), 6 with anorexia nervosa binge-eating/purging type (ANBP), and 8 controls (C). RESULTS:Compared with controls, significantly elevated percentage of CD4 and CD4/CD8 ratio in ANBP was found. Although there was no significant difference in lymphoproliferative response among the three groups, sIL-2R in RAN was significantly lower than that in the C group, but not in ANBP. CONCLUSIONS:Although detail mechanism still remains to be unknown, some kinds of compensatory mechanism for cell-mediated immunity is working, especially in chronic underweight anorexic patients.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Nagata T,Kiriike N,Tobitani W,Kawarada Y,Matsunaga H,Yamagami S

doi

10.1016/s0006-3223(98)00082-1

subject

Has Abstract

pub_date

1999-02-15 00:00:00

pages

471-4

issue

4

eissn

0006-3223

issn

1873-2402

pii

S0006322398000821

journal_volume

45

pub_type

杂志文章

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