Brain serotonin 1A receptor binding in bulimia nervosa.

abstract：BACKGROUND:Recent research has demonstrated that clinical depression can emerge as early as the preschool period. Here, we examine brain function in children with a history of preschool-onset depression (PO-MDD) in comparison with healthy children. METHODS:Participants were medication naïve school-aged children (ages ...

journal_title：Biological psychiatry

authors： Barch DM,Gaffrey MS,Botteron KN,Belden AC,Luby JL

更新日期：2012-12-15 00:00:00

abstract：BACKGROUND:Major depressive disorder (MDD) in the adolescent demonstrates a unique clinical profile, and pathogenic serotonergic dysregulation is hypothesized. Parenteral clomipramine (CMI) is known to distinguish adult MDD from control, but neurochallenge data are lacking in adolescent MDD. METHODS:Thirteen drug-free...

journal_title：Biological psychiatry

authors： Sallee FR,Vrindavanam NS,Deas-Nesmith D,Odom AM,Carson SW,Sethuraman G

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Cognitive abnormalities are increasingly recognized as a feature of bipolar I disorder (BDI,) but there is limited information regarding the pattern and severity of cognitive impairment during remission and its relationship with clinical variables. METHODS:Forty-four remitted BDI patients recruited from a r...

journal_title：Biological psychiatry

authors： Frangou S,Donaldson S,Hadjulis M,Landau S,Goldstein LH

更新日期：2005-12-01 00:00:00

abstract：:Since publication of the first randomized controlled trial describing rapid antidepressant effects of ketamine, several reports have confirmed the potential utility of this dissociative anesthetic medication for treatment of major depressive episodes, including those associated with bipolar disorder and resistant to o...

journal_title：Biological psychiatry

authors： Aan Het Rot M,Zarate CA Jr,Charney DS,Mathew SJ

更新日期：2012-10-01 00:00:00

abstract：:Using magnetic resonance imaging (MRI), we measured the volumes of various brain structures and cerebrospinal fluid (CSF) in 19 men with dementia of the Alzheimer type (DAT) and 18 healthy age-matched control men. The mean (+/- S.D) Mini-Mental State exam score (MMSE) of the DAT men was 16 +/- 7; 9 were mildly (MMSE >...

journal_title：Biological psychiatry

authors： Murphy DG,DeCarli CD,Daly E,Gillette JA,McIntosh AR,Haxby JV,Teichberg D,Schapiro MB,Rapoport SI,Horwitz B

更新日期：1993-11-01 00:00:00

abstract：:Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with 18F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of ...

journal_title：Biological psychiatry

authors： DeLisi LE,Buchsbaum MS,Holcomb HH,Langston KC,King AC,Kessler R,Pickar D,Carpenter WT Jr,Morihisa JM,Margolin R

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Buprenorphine (BUP) is effective in the treatment of opioid dependence when given on alternating days, probably as a result of long-lasting occupation of micro opioid receptors (microORs). This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic ...

journal_title：Biological psychiatry

authors： Greenwald M,Johanson CE,Bueller J,Chang Y,Moody DE,Kilbourn M,Koeppe R,Zubieta JK

更新日期：2007-01-01 00:00:00

abstract：:We investigated the computerized electroencephalography (cEEG) in a group of 85 normal adolescents. The spatial frequency of the cEEG was analyzed using various multivariate statistical techniques. The factor analyses revealed three factors that accounted for most of the variability in the data and that could be inter...

journal_title：Biological psychiatry

authors： Volkow ND,Gomez-Mont F,Inamdar S,Lamella M,Prichep L,John R

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Methylphenidate has been shown elsewhere to improve hyperactivity in about half of treated children who have pervasive developmental disorders (PDD) and significant hyperactive-inattentive symptoms. We present secondary analyses to better define the scope of effects of methylphenidate on symptoms that define...

journal_title：Biological psychiatry

authors： Posey DJ,Aman MG,McCracken JT,Scahill L,Tierney E,Arnold LE,Vitiello B,Chuang SZ,Davies M,Ramadan Y,Witwer AN,Swiezy NB,Cronin P,Shah B,Carroll DH,Young C,Wheeler C,McDougle CJ

更新日期：2007-02-15 00:00:00

abstract：BACKGROUND:Language delay is a hallmark feature of autism spectrum disorders (ASD). The identification of word boundaries in continuous speech is a critical first step in language acquisition that can be accomplished via statistical learning and reliance on speech cues. Importantly, early word segmentation skills have ...

journal_title：Biological psychiatry

authors： Scott-Van Zeeland AA,McNealy K,Wang AT,Sigman M,Bookheimer SY,Dapretto M

更新日期：2010-08-15 00:00:00

abstract：BACKGROUND:A polymorphism in the serotonin transporter (5-HTT) gene modulates the association between adverse early experiences and risk for major depression in adulthood. Although human imaging studies have begun to elucidate the neural circuits involved in the 5-HTT x environment risk factor, a molecular understandin...

journal_title：Biological psychiatry

authors： Carola V,Frazzetto G,Pascucci T,Audero E,Puglisi-Allegra S,Cabib S,Lesch KP,Gross C

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Preclinical and clinical evidence indicate that the glutamatergic system might play a role in the pathophysiology of mood disorders. This study was conducted to determine the efficacy and safety of riluzole, a glutamate-modulating agent, in bipolar depression. METHODS:This was an 8-week add-on study of rilu...

journal_title：Biological psychiatry

authors： Zarate CA Jr,Quiroz JA,Singh JB,Denicoff KD,De Jesus G,Luckenbaugh DA,Charney DS,Manji HK

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:The DTNBP1 gene, encoding dysbindin, has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 ...

journal_title：Biological psychiatry

authors： Morris DW,Murphy K,Kenny N,Purcell SM,McGhee KA,Schwaiger S,Nangle JM,Donohoe G,Clarke S,Scully P,Quinn J,Meagher D,Baldwin P,Crumlish N,O'Callaghan E,Waddington JL,Gill M,Corvin AP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to describe the distribution of regional cerebral blood flow during the hypnotic state (HS) in humans, using positron-emission tomography (PET) and statistical parametric mapping. METHODS:The hypnotic state relied on revivification of pleasant autobiographical memories and w...

journal_title：Biological psychiatry

authors： Maquet P,Faymonville ME,Degueldre C,Delfiore G,Franck G,Luxen A,Lamy M

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Substantial evidence indicates that alcoholism is biologically mediated by a genetic predisposition. As the decreased P300 (P3b) event-related brain potential component does not recover with prolonged abstinence, it is unlikely to be related to drinking history but is more likely to be genetically influenced...

journal_title：Biological psychiatry

authors： Hada M,Porjesz B,Chorlian DB,Begleiter H,Polich J

更新日期：2001-04-15 00:00:00

abstract：:This review describes the strategy of using elementary phenotypes for neurobiological and genetic linkage studies of schizophrenia. The review concentrates on practical aspects of selecting the phenotype and then understanding the confounds in its measurement and interpretation. Examples from the authors' studies of d...

journal_title：Biological psychiatry

authors： Adler LE,Freedman R,Ross RG,Olincy A,Waldo MC

更新日期：1999-07-01 00:00:00

abstract：:Neuroendocrine functions in depressed patients with major affective disorders were serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI) measurement. Prior to antidepressant therapy, the sensitivity...

journal_title：Biological psychiatry

authors： Itoh N,Matsui N,Fuwano S,Yaginuma H,Miyashita O,Sakai M

更新日期：1987-05-01 00:00:00

abstract：:Traumatic events are common, but posttraumatic stress disorder (PTSD) is relatively rare. These facts have prompted several questions: What variables increase risk for PTSD among trauma-exposed people? Can we distinguish between pathologic and nonpathologic responses to traumatic stressors? If so, what psychobiologica...

journal_title：Biological psychiatry

authors： McNally RJ

更新日期：2003-05-01 00:00:00

abstract：:A decreased secretion of arginine vasopressin (AVP) has been implicated in depression. In order to further investigate this hypothesis, we studied the plasma level of the specific peptidergic carrier of AVP, vasopressin neurophysin (hNpI), in 26 depressed inpatients and 16 matched normal controls. On the other hand, A...

journal_title：Biological psychiatry

authors： Laruelle M,Seghers A,Goffinet S,Bouchez S,Legros JJ

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Identifying factors that modify responsiveness to pharmacotherapies for alcohol dependence is important for treatment planning. Cigarette smoking predicts more severe alcohol dependence and poorer treatment response in general. Nevertheless, there is limited research on cigarette smoking as a potential predi...

journal_title：Biological psychiatry

authors： Fucito LM,Park A,Gulliver SB,Mattson ME,Gueorguieva RV,O'Malley SS

更新日期：2012-11-15 00:00:00

abstract：:The validity of previously hypothesized predictors of elapse following neuroleptic discontinuation was examined. One hundred sixty-two outpatients, with either Research Diagnostic Criteria schizophrenia or schizoaffective disorder, were discontinued from neuroleptic medication for a 28-day period or until judged to be...

journal_title：Biological psychiatry

authors： Buchanan RW,Kirkpatrick B,Summerfelt A,Hanlon TE,Levine J,Carpenter WT Jr

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Reduction in a pre-attentive measure of auditory change detection, mismatch negativity (MMN), is one of the most consistent findings in schizophrenia. Recently, our group showed a reduction in MMN to changes in the duration and intensity of background sounds in those within 5 years of illness onset, whereas ...

journal_title：Biological psychiatry

authors： Atkinson RJ,Michie PT,Schall U

更新日期：2012-01-15 00:00:00

abstract：BACKGROUND:Despite a prominent malnourished state, anorexics are unexpectedly free from infection. Several studies have shown that the cell-mediated immunity of anorexics might be well preserved, but results are conflicting. METHODS:Lymphocyte subsets, lymphoproliferative response to phytohemagglutinin, and soluble in...

journal_title：Biological psychiatry

authors： Nagata T,Kiriike N,Tobitani W,Kawarada Y,Matsunaga H,Yamagami S

更新日期：1999-02-15 00:00:00

abstract：BACKGROUND:A facial discrimination task was adapted to be used in an event-related potential (ERP) paradigm in order to evaluate whether young women's brain responses to affective stimuli differed from those of young men. METHODS:The stimuli used to generate a late positive component of the ERP, designated the "P450,"...

journal_title：Biological psychiatry

authors： Orozco S,Ehlers CL

更新日期：1998-08-15 00:00:00

abstract：:The smooth pursuit responses to 5 degrees and 20 degrees/sec constant-velocity stimuli were recorded from 23 patients with schizophrenia, 16 affective disorder patients, and 21 normals using low-noise infrared oculography. Pursuit gain, catch-up saccade (CUS) rate and amplitude, and their interrelationships were exami...

journal_title：Biological psychiatry

authors： Abel LA,Friedman L,Jesberger J,Malki A,Meltzer HY

更新日期：1991-06-01 00:00:00

abstract：:There has been a continuing interest in the possible role of the trace amine tryptamine in the etiology of neuropsychiatric disorders. We have therefore examined cerebrospinal fluid (CSF) levels of indole-3-acetic acid (IAA), the major metabolite of tryptamine, in a large group of normals and in several patient popula...

journal_title：Biological psychiatry

authors： Anderson GM,Gerner RH,Cohen DJ,Fairbanks L

更新日期：1984-10-01 00:00:00

abstract：:This study is designed to measure effects of serotonin 1A (5-HT1A) agonists on escape deficits produced by inescapable shock in rats--a model of learned helplessness. Rats were first exposed to 60 inescapable shocks (15-sec duration, 0.8 mA, every 1 min +/- 15 sec), and 48 hr later, they were subjected to daily 15-min...

journal_title：Biological psychiatry

authors： Giral P,Martin P,Soubrié P,Simon P

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:After no research in humans for >40 years, there is renewed interest in using lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no modern studies on the subjective and autonomic effects of LSD, and its endocrine effects are unknown. In animals, LSD disrupts prepulse in...

journal_title：Biological psychiatry

authors： Schmid Y,Enzler F,Gasser P,Grouzmann E,Preller KH,Vollenweider FX,Brenneisen R,Müller F,Borgwardt S,Liechti ME

更新日期：2015-10-15 00:00:00

abstract：:Studies at the basic and clinical levels demonstrate that neuronal atrophy and cell death occur in response to stress and in the brains of depressed patients. Although the mechanisms have yet to be fully elucidated, progress has been made in characterizing the signal transduction cascades that control neuronal atrophy...

journal_title：Biological psychiatry

authors： Duman RS,Malberg J,Nakagawa S,D'Sa C

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:The goal of this study was to identify chromosomal regions likely to contain susceptibility loci for obsessive-compulsive disorder (OCD). METHODS:We conducted a genome-wide linkage scan, with average marker spacing less than 10 centimorgans (cM), in 121 subjects from 26 families ascertained through probands...

journal_title：Biological psychiatry

authors： Hanna GL,Veenstra-Vanderweele J,Cox NJ,Van Etten M,Fischer DJ,Himle JA,Bivens NC,Wu X,Roe CA,Hennessy KA,Dickel DE,Leventhal BL,Cook EH Jr

更新日期：2007-10-15 00:00:00