Abstract：
BACKGROUND:A facial discrimination task was adapted to be used in an event-related potential (ERP) paradigm in order to evaluate whether young women's brain responses to affective stimuli differed from those of young men. METHODS:The stimuli used to generate a late positive component of the ERP, designated the "P450," were male and female faces with neutral, sad, or happy facial expressions. Subjects were instructed to respond to the happy and sad faces but not to the neutral faces. The amplitude and latency of the P450 component was evaluated with respect to the gender of the subject, as well as the gender and emotional affect of the facial stimuli themselves. RESULTS:In all subjects, the sad faces elicited longer latency and higher amplitude P450 components as compared to the happy faces. Female subjects were found to generate significantly longer latency and higher amplitude P450 components than male subjects to both happy and sad faces. All subjects were found to respond more quickly to: male happy faces > female happy faces > female sad faces > male sad faces. CONCLUSIONS:These data suggest that the morphology of the late positive component of the ERP differs depending on the emotional expression of the stimuli, the gender of the facial stimulus, and the gender of the subject.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Orozco S,Ehlers CLdoi
10.1016/s0006-3223(97)00487-3subject
Has Abstractpub_date
1998-08-15 00:00:00pages
281-9issue
4eissn
0006-3223issn
1873-2402pii
S0006-3223(97)00487-3journal_volume
44pub_type
杂志文章abstract：BACKGROUND:Depression is a complex neuropsychiatric syndrome that is often very severe and life threatening. In spite of the remarkable progress in understanding the neural biology, the etiopathophysiology of depression is still elusive. In this study, we have investigated molecular mechanisms in the prefrontal cortex ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.09.024
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Investigators have reported lack of normal asymmetry of lateralization in some schizophrenic patients, as measured postmortem and by preference and/or performance. It has been suggested that this lack of asymmetry is related to early onset of schizophrenia. The present study extends the inquiry by magnetic r...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(98)00076-6
更新日期：1998-09-15 00:00:00
abstract：BACKGROUND:Studies in elderly patients demonstrate antipsychotic efficacy and favorable safety profiles for olanzapine. We report results from two placebo-controlled, double-blind studies of olanzapine for treatment of dopamimetic drug-induced psychosis in patients with Parkinson's disease (PD). METHODS:Patients were ...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0006-3223(02)01392-6
更新日期：2002-09-01 00:00:00
abstract：:Both genetic and environmental factors have been associated with an increased risk for schizophrenia. These factors are not mutually exclusive; a single gene can be a genetic factor (due to a mutation in the gene sequence) and a target of a physiological response to an environmental stimulus, both with the common endp...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2006.04.028
更新日期：2006-09-15 00:00:00
abstract：:Neuroendocrine functions in depressed patients with major affective disorders were serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI) measurement. Prior to antidepressant therapy, the sensitivity...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90184-3
更新日期：1987-05-01 00:00:00
abstract：BACKGROUND:Identifying factors that modify responsiveness to pharmacotherapies for alcohol dependence is important for treatment planning. Cigarette smoking predicts more severe alcohol dependence and poorer treatment response in general. Nevertheless, there is limited research on cigarette smoking as a potential predi...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2012.03.023
更新日期：2012-11-15 00:00:00
abstract：:Event-related potentials (ERPs) and electrodermal activity were studied in 14 medicated schizophrenics, 17 unmedicated schizophrenics, and 23 age- and education-matched controls. Subjects were run in three auditory stimulus paradigms differing from the usual ERP paradigms in having interstimulus intervals greater than...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90094-3
更新日期：1991-03-15 00:00:00
abstract：:Platelet MAO activity in schizophrenics was significantly decreased, by about 15%, after 3 weeks of treatment with haloperidol. Treatment with thioridazine or butaperazine also tended to decrease platelet MAO activity. The neuroleptic-induced decrease began to appear within a few days of treatment and did not show tol...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
abstract：BACKGROUND:In schizophrenia (SZ), disturbances in integration of activity among brain regions seem to be as important as abnormal activity of any single region. Brain regions are connected through white matter (WM) tracts, and diffusion tensor imaging has provided compelling evidence for WM abnormalities in SZ. However...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.03.003
更新日期：2013-09-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90053-x
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND:As many as 30% of individuals diagnosed with depression are nonresponsive to traditional antidepressant medication. Augmentation and combination strategies have emerged in an attempt to address this issue. Atypical antipsychotics (e.g., olanzapine), when added to a selective serotonin reuptake inhibitor (e.g...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.02.012
更新日期：2004-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(96)00046-7
更新日期：1996-11-15 00:00:00
abstract：:We examined the circadian rhythm of core body temperature (CBT) in 22 school refusal patients, ages between 12 and 18 years, who did not have any physical or psychiatric disorders, but had indefinite complaints, and were suspected to have a circadian rhythm disturbance. To obtain normal data for analysis, CBT in 9 hea...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(96)00179-5
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND:Disruptions of emotional information processing (i.e., attention to, memory for, and interpretation of emotional information) have been implicated in the onset and maintenance of depression. The research presented here investigated cognitive and psychophysiological features of a particularly promising correl...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(00)01024-6
更新日期：2001-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.08.021
更新日期：2013-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00253-4
更新日期：1999-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2015.03.014
更新日期：2016-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.11.009
更新日期：2008-04-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.05.032
更新日期：2009-10-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00138-3
更新日期：1998-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90133-8
更新日期：1987-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is characterized by deficits in reward sensitivity and response inhibition. The relative contribution of these frontostriatal mechanisms to ADHD symptoms and their genetic determinants is largely unexplored. METHODS:Using functional magnetic resonance imaging ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.03.027
更新日期：2013-10-15 00:00:00
abstract：BACKGROUND:Gray and white matter volume deficits have been reported in many structural magnetic resonance imaging (MRI) studies of children with attention-deficit/hyperactivity disorder (ADHD); however, there is a paucity of structural MRI studies of adults with ADHD. This study used voxel based morphometry and applied...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.09.053
更新日期：2011-05-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.04.041
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that intravenous administration of the N-methyl-D-aspartate antagonist ketamine produced rapid antidepressant effects in patients with treatment...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2011.12.010
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) and tic disorders have phenomenological and familial-genetic overlaps. An OCD family study sample that excludes Tourette's syndrome in probands is used to examine whether tic disorders are part of the familial phenotype of OCD. METHODS:Eighty case and 73 control probands ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01074-5
更新日期：2001-10-15 00:00:00
abstract：:It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal events. It is clear that the interaction between genetic predisposition and early life environment...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2018.06.014
更新日期：2019-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.11.004
更新日期：2010-03-15 00:00:00
abstract：:Opponent processes have long been known to be a basic building block of neural circuits. This article describes properties of opponent processes in which phasic cues and tonic arousal are gated by slowly accumulating chemical transmitters. These opponent processes are called gated dipoles. Gated dipole circuits exhibi...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
