当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia.

Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia.

Abstract：

BACKGROUND:Problems with the voluntary control of behavior, such as those leading to increased antisaccade errors, are accepted as evidence of prefrontal dysfunction in schizophrenia. We previously reported that speeded prosaccade responses, i.e., shorter response latencies for automatic shifts of attention to visual targets, were associated with higher antisaccade error rates in schizophrenia. This suggests that dysregulation of automatic attentional processes may contribute to disturbances in prefrontally mediated control of voluntary behavior. METHODS:Twenty-four antipsychotic-naïve schizophrenia patients and 30 healthy individuals completed three tasks: a no-gap prosaccade task in which subjects shifted gaze toward a peripheral target that appeared coincident with the disappearance of a central fixation target and separate prosaccade and antisaccade tasks in which a temporal gap or overlap of the central target offset and peripheral target onset occurred. Sixteen patients were retested after 6 weeks of antipsychotic treatment. RESULTS:Patients' prosaccade latencies in the no-gap task were speeded compared with healthy individuals. While patients were not atypical in the degree to which response latencies were speeded or slowed by the gap and overlap manipulations, those patients with diminished attentional engagement on the prosaccade task (i.e., reduced overlap effect) had significantly elevated antisaccade error rates. This effect persisted in patients evaluated after antipsychotic treatment. CONCLUSIONS:This study provides evidence that a reduced ability to engage attention may render patients more distracted by sensory inputs, thereby further compromising impaired executive control during antisaccade tasks. Thus, alterations in attentional and executive control functions can synergistically disrupt voluntary behavioral responses in schizophrenia.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Reilly JL,Harris MS,Khine TT,Keshavan MS,Sweeney JA

doi

10.1016/j.biopsych.2007.11.009

subject

Has Abstract

pub_date

2008-04-15 00:00:00

pages

776-83

issue

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(07)01103-1

journal_volume

pub_type

杂志文章

在线工具

Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia.