Abstract:
BACKGROUND:Loss of motivation is a characteristic feature of several psychiatric and neurological disorders. However, the neural mechanisms underlying human motivation are far from being understood. Here, we investigate the role that the frontopolar cortex (FPC) plays in motivating cognitive and physical effort exertion by computing subjective effort equivalents. METHODS:We manipulated neural processing with transcranial direct current stimulation targeting the FPC while 141 healthy participants decided whether or not to engage in cognitive or physical effort to obtain rewards. RESULTS:We found that brain stimulation targeting the FPC increased the amount of both types of effort participants were willing to exert for rewards. CONCLUSIONS:Our findings provide important insights into the neural mechanisms involved in motivating effortful behavior. Moreover, they suggest that considering the motivation-related activity of the FPC could facilitate the development of treatments for the loss of motivation commonly seen in psychiatric and other neurological disorders.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Soutschek A,Kang P,Ruff CC,Hare TA,Tobler PNdoi
10.1016/j.biopsych.2017.11.007subject
Has Abstractpub_date
2018-07-01 00:00:00pages
38-45issue
1eissn
0006-3223issn
1873-2402pii
S0006-3223(17)32192-3journal_volume
84pub_type
杂志文章abstract:BACKGROUND:Psychological stress and trauma are risk factors for several medical and psychiatric illnesses. Recent studies have implicated advanced cellular aging as a potential mechanism of this association. Telomeres, DNA repeats that cap the ends of chromosomes and promote stability, shorten progressively with each c...
journal_title:Biological psychiatry
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2006-01-15 00:00:00
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.03.020
更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.04.026
更新日期:2012-11-15 00:00:00
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journal_title:Biological psychiatry
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更新日期:2001-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,meta分析
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更新日期:2005-05-01 00:00:00
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doi:10.1016/0006-3223(90)90018-w
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更新日期:2000-10-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1986-03-01 00:00:00
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更新日期:2017-07-15 00:00:00
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更新日期:1996-08-15 00:00:00
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pub_type: 杂志文章
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更新日期:1986-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0006-3223(98)00340-0
更新日期:1999-04-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2006-09-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(88)90080-7
更新日期:1988-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(93)90293-m
更新日期:1993-02-15 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1997-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2011-06-15 00:00:00