Validity of plasma factor in schizophrenia as measured by tryptophan uptake.

abstract：:Specific electroencephalogram (EEG) changes during clozapine therapy were prospectively studied in a cohort of 50 chronic state hospital patients with schizophrenia who were randomly assigned to one of three nonoverlapping clozapine serum level ranges (50-150 ng/mL, 200-300 ng/mL, and 350-450 ng/mL). EEGs were obtaine...

journal_title：Biological psychiatry

authors： Freudenreich O,Weiner RD,McEvoy JP

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Schizophrenic patients have high rates of cigarette smoking compared with the general population. We compared sustained-release (SR) bupropion with placebo for smoking cessation in patients with schizophrenic disorders. We also examined how antipsychotic class predicts smoking cessation outcomes with bupropi...

journal_title：Biological psychiatry

authors： George TP,Vessicchio JC,Termine A,Bregartner TA,Feingold A,Rounsaville BJ,Kosten TR

更新日期：2002-07-01 00:00:00

abstract：:The present study was undertaken to investigate if acute anxiety can affect plasma concentrations of homovanillic acid (pHVA). Since elevated pHVA levels have been associated with severity of schizophrenic symptoms, the results of this study will help determine if the pHVA elevations are directly related to psychosis ...

journal_title：Biological psychiatry

authors： Zemishlany Z,Davidson M

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Venlafaxine blocks both serotonin and norepinephrine transporters (SERT and NET), with higher affinity for SERT. Serotonergic effects occur with lower doses, whereas both serotonergic and noradrenergic effects occur with higher doses of venlafaxine. Chronic treatment of rats with selective serotonin reuptake...

journal_title：Biological psychiatry

authors： Gould GG,Altamirano AV,Javors MA,Frazer A

更新日期：2006-03-01 00:00:00

abstract：:We compared the EEG-monitored sleep of 8 women with anorexia nervosa and 16 normal weight women with bulimia to that of 14 normal women. The patients with anorexia nervosa spent less time asleep and spent less of their sleep time in Stage 1. The sleep of the normal weight patients with bulimia was remarkably similar t...

journal_title：Biological psychiatry

authors： Walsh BT,Goetz R,Roose SP,Fingeroth S,Glassman AH

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Current pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) suggest that impaired functional connectivity within brain attention networks may contribute to the disorder. In this electroencephalographic (EEG) study, we analyzed cross-frequency amplitude correlations to investigate diffe...

journal_title：Biological psychiatry

authors： Mazaheri A,Coffey-Corina S,Mangun GR,Bekker EM,Berry AS,Corbett BA

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill. METHODS:We studied young individuals with at least two relatives with the di...

journal_title：Biological psychiatry

authors： Whalley HC,Simonotto E,Moorhead W,McIntosh A,Marshall I,Ebmeier KP,Owens DG,Goddard NH,Johnstone EC,Lawrie SM

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Long term medication with antipsychotic drugs is known to produce changes in neurotransmitter levels and receptor sensitivity in the cortex; however, the anatomic consequences of chronic antipsychotic exposure are not well established. METHODS:Accordingly, rhesus monkeys were given daily oral doses of typic...

journal_title：Biological psychiatry

authors： Selemon LD,Lidow MS,Goldman-Rakic PS

更新日期：1999-07-15 00:00:00

abstract：BACKGROUND:Pediatric Bipolar Disorder (BD) has been associated with a number of neurocognitive deficits not dissimilar to ADHD. This study compared neuropsychological profiles of 4 groups of adolescents (14-17 years): 41 Normal Controls (NC), 30 ADHD, 12 BD and 12 combined (BD+ADHD). METHODS:Participants were identifi...

journal_title：Biological psychiatry

authors： Rucklidge JJ

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Disruptions of emotional information processing (i.e., attention to, memory for, and interpretation of emotional information) have been implicated in the onset and maintenance of depression. The research presented here investigated cognitive and psychophysiological features of a particularly promising correl...

journal_title：Biological psychiatry

authors： Siegle GJ,Granholm E,Ingram RE,Matt GE

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ. METHODS:Twenty five male SCZ subjects (SCZs) (18 antipsychotic treated and 7 antipsychotic free) were compared wit...

journal_title：Biological psychiatry

authors： Ranganathan M,Cortes-Briones J,Radhakrishnan R,Thurnauer H,Planeta B,Skosnik P,Gao H,Labaree D,Neumeister A,Pittman B,Surti T,Huang Y,Carson RE,D'Souza DC

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:Some studies suggest that cortisol may be under genetic control. The aims of our study were to investigate the familial resemblance in morning and evening cortisol secretion as assessed by saliva cortisol and to assess the influence of history of major depression. METHODS:Women for this investigation were s...

journal_title：Biological psychiatry

authors： Young EA,Aggen SH,Prescott CA,Kendler KS

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Difficulty with impulse control is heightened in children with a family history of alcohol use disorders and is a risk factor for later substance problems. Cross-sectional functional magnetic resonance imaging studies have shown altered impulse control processing in adolescents with a positive family history...

journal_title：Biological psychiatry

authors： Hardee JE,Weiland BJ,Nichols TE,Welsh RC,Soules ME,Steinberg DB,Zubieta JK,Zucker RA,Heitzeg MM

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Recent findings suggest that both low and very high fasting blood glucose concentrations may be linked with depression, though whether type 2 diabetes is associated with depression may depend on awareness of the diagnosis. We explored the association between fasting glucose and type 2 diabetes (undiagnosed a...

journal_title：Biological psychiatry

authors： Gale CR,Kivimaki M,Lawlor DA,Carroll D,Phillips AC,Batty GD

更新日期：2010-01-15 00:00:00

abstract：:Our previous studies have shown that in psychotics, the plasma serine level is abnormally high and that plasma serine hydroxymethyltransferase (which cleaves serine to glycine) activity is abnormally low as compared with that in nonpsychotic subjects. In this study, psychotic and nonpsychotic subjects ingested a large...

journal_title：Biological psychiatry

authors： Wilcox J,Waziri R,Sherman A,Mott J

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females. METHODS:We described brain growth trajectories in 55 girls with TS and...

journal_title：Biological psychiatry

authors： O'Donoghue S,Green T,Ross JL,Hallmayer J,Lin X,Jo B,Huffman LC,Hong DS,Reiss AL

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting quality of life. Sensory inputs reaching the primary motor cortex (M1) from the somatosensory cortex (S1) are likely involved in fine motor skill and specifically motor learning. However, the role of these conn...

journal_title：Biological psychiatry

authors： Thompson A,Murphy D,Dell'Acqua F,Ecker C,McAlonan G,Howells H,Baron-Cohen S,Lai MC,Lombardo MV,MRC AIMS Consortium, and Marco Catani.

更新日期：2017-02-01 00:00:00

abstract：:Unlike disorders of other fields of medicine (eg., diabetes, heart disease), schizophrenia has been only marginally impacted by the study of animal models. This gap reflects the incomplete understanding of the causes and mechanisms of schizophrenia and the resulting lack of defined targets for model development. Howev...

journal_title：Biological psychiatry

authors： Kilts CD

更新日期：2001-12-01 00:00:00

abstract：:Converging lines of evidence suggest a role for the mesolimbic dopamine system in the response to somatic antidepressant therapies. Here, we review evidence suggesting that antidepressant treatments of different types share the effect of increasing the sensitivity of dopamine D2-like receptors in the nucleus accumbens...

journal_title：Biological psychiatry

authors： Gershon AA,Vishne T,Grunhaus L

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined. METHODS:Postmortem samples from the orbitofrontal cortex (ORB) were colle...

journal_title：Biological psychiatry

authors： Rajkowska G,Miguel-Hidalgo JJ,Dubey P,Stockmeier CA,Krishnan KR

更新日期：2005-08-15 00:00:00

abstract：BACKGROUND:Frequent electroencephalographic arousals or awakenings associated with periodic leg movements (PLM) might be responsible in part for the complaints of sleep disturbances made by patients treated with antidepressants. Past studies, however, have determined the effects of only certain limited antidepressants,...

journal_title：Biological psychiatry

authors： Yang C,White DP,Winkelman JW

更新日期：2005-09-15 00:00:00

abstract：:Depersonalization and other behavioral and physiological indices were monitored before and after the administration of high- and low-potency marijuana cigarettes and a placebo cigarette in 35 physically and mentally healthy normal volunteers. The cigarettes were administered under double-blind conditions during three ...

journal_title：Biological psychiatry

authors： Mathew RJ,Wilson WH,Humphreys D,Lowe JV,Weithe KE

更新日期：1993-03-15 00:00:00

abstract：BACKGROUND:Despite a prominent malnourished state, anorexics are unexpectedly free from infection. Several studies have shown that the cell-mediated immunity of anorexics might be well preserved, but results are conflicting. METHODS:Lymphocyte subsets, lymphoproliferative response to phytohemagglutinin, and soluble in...

journal_title：Biological psychiatry

authors： Nagata T,Kiriike N,Tobitani W,Kawarada Y,Matsunaga H,Yamagami S

更新日期：1999-02-15 00:00:00

abstract：BACKGROUND:Generalized social phobia (gSP), also known as generalized social anxiety disorder, is characterized by excessive fear of scrutiny by others and pervasive avoidance of social interactions. Pathophysiologic models of gSP implicate exaggerated reactivity of the amygdala and insula in response to social evaluat...

journal_title：Biological psychiatry

authors： Phan KL,Coccaro EF,Angstadt M,Kreger KJ,Mayberg HS,Liberzon I,Stein MB

更新日期：2013-02-15 00:00:00

abstract：:Interpersonal and social rhythm therapy is an individual psychotherapy designed specifically for the treatment for bipolar disorder. Interpersonal and social rhythm therapy grew from a chronobiological model of bipolar disorder postulating that individuals with bipolar disorder have a genetic predisposition to circadi...

journal_title：Biological psychiatry

authors： Frank E,Swartz HA,Kupfer DJ

更新日期：2000-09-15 00:00:00

abstract：BACKGROUND:In the Systematic Treatment Enhancement Program for Bipolar Disorder, we showed that valproate is associated with new-onset menstrual-cycle irregularities and hyperandrogenism in 10.5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation. ME...

journal_title：Biological psychiatry

authors： Joffe H,Cohen LS,Suppes T,Hwang CH,Molay F,Adams JM,Sachs GS,Hall JE

更新日期：2006-12-15 00:00:00

abstract：:The effect of nortriptyline was assessed on the EEG sleep of 20 inpatients with major depressive syndrome. While 25 mg of nortriptyline had an immediate effect on REM sleep variables, relatively little influence on sleep continuity measures was noted. Subsequent administration of 75 and 100 mg of nortriptyline produce...

journal_title：Biological psychiatry

authors： Kupfer DJ,Spiker DG,Rossi A,Coble PA,Shaw D,Ulrich R

更新日期：1982-05-01 00:00:00

abstract：:Pre-treatment and posttreatment dexamethasone suppression test (DST) results in physically healthy elderly major depressives without dementia demonstrated an association between treatment and DST normalization. Sixty percent of subjects were nonsuppressors at baseline compared to 17% after intensive treatment. DST res...

journal_title：Biological psychiatry

authors： Meyers BS,Alpert S,Gabriele M,Kakuma T,Kalayam B,Alexopoulos GS

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Traditionally, norepinephrine has been associated with stress responses, whereas dopamine has been associated with reward. Both of these catecholamines are found within the bed nucleus of the stria terminalis (BNST), a brain relay nucleus in the extended amygdala between cortical/limbic centers, and the hypo...

journal_title：Biological psychiatry

authors： Park J,Wheeler RA,Fontillas K,Keithley RB,Carelli RM,Wightman RM

更新日期：2012-02-15 00:00:00

abstract：:The pharmacokinetics of dexamethasone (DEX) were studied in 9 drug-free melancholically depressed patients and 10 healthy control subjects matched by sex and age. Each subject received 1 mg of DEX administered orally and by the (i.v.) route at 11:00 PM and serial blood samples were collected over the next 17 hours unt...

journal_title：Biological psychiatry

authors： O'Sullivan BT,Cutler DJ,Hunt GE,Walters C,Johnson GF,Caterson ID

更新日期：1997-03-01 00:00:00