The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: a meta-analysis.

abstract：:It has been proposed that the nailfold subpapillary plexus visibility score (PVS) may be a marker of susceptibility to schizophrenia. To further investigate this hypothesis, we evaluated plexus visibility in a sample of 61 chronic schizophrenics, a large sample of first-episode psychotic patients and their first-degre...

journal_title：Biological psychiatry

authors： Clementz BA,Iacono WG,Ficken J,Beiser M

更新日期：1992-02-15 00:00:00

abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder characterized by deficits in attention, increased motor impulsivity, and hyperactivity. Preliminary work in mice and humans has suggested the X-linked gene STS (which encodes the enzyme steroid sulfatase) as a mediator o...

journal_title：Biological psychiatry

authors： Davies W,Humby T,Kong W,Otter T,Burgoyne PS,Wilkinson LS

更新日期：2009-08-15 00:00:00

abstract：:There is recognition that the cognitive symptoms of schizophrenia have the most substantial impact on illness outcome. Domains of cognition reported to be significantly affected include serial learning, executive function, vigilance, and distractibility, to name a few. Dopamine activity at D1 receptors mediates many c...

journal_title：Biological psychiatry

authors： Friedman JI,Temporini H,Davis KL

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Volumetric imaging research has shown abnormal brain morphology in adults with posttraumatic stress disorder (PTSD) when compared with matched control subjects. In this article, we present brain imaging findings from a study of children with PTSD symptoms. METHODS:Twenty-four children between the ages of 7 ...

journal_title：Biological psychiatry

authors： Carrion VG,Weems CF,Eliez S,Patwardhan A,Brown W,Ray RD,Reiss AL

更新日期：2001-12-15 00:00:00

abstract：BACKGROUND:Previous magnetic resonance imaging (MRI) studies indicate that compared with healthy volunteers, patients with bipolar disorder have structural and functional abnormalities in the prefrontal cortex. The aim of this study was to investigate differences in prefrontal subregions between bipolar patients and he...

journal_title：Biological psychiatry

authors： López-Larson MP,DelBello MP,Zimmerman ME,Schwiers ML,Strakowski SM

更新日期：2002-07-15 00:00:00

abstract：:This paper reviews and correlates three separate recent findings that implicate the one-carbon cycle in neuropsychiatric disease: (i) the demonstration by kinetic studies that the Vmax of methionine adenosine transferase (MAT) is reduced in some schizophrenics and depressives and is increased in some manics, and that ...

journal_title：Biological psychiatry

authors： Smythies JR

更新日期：1984-05-01 00:00:00

abstract：:There is increasing evidence of a deficit or disturbance of neurons in the brains of schizophrenic patients--evidence that particularly implicates the frontal or temporal lobes. As yet there is no direct neurochemical correlate of the transmitter systems involved, although changes in some neurotransmitters in the temp...

journal_title：Biological psychiatry

authors： Reynolds GP,Czudek C,Andrews HB

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Buprenorphine (BUP) is effective in the treatment of opioid dependence when given on alternating days, probably as a result of long-lasting occupation of micro opioid receptors (microORs). This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic ...

journal_title：Biological psychiatry

authors： Greenwald M,Johanson CE,Bueller J,Chang Y,Moody DE,Kilbourn M,Koeppe R,Zubieta JK

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The ability to stop a suboptimal response is integral to decision making and is commonly impaired across psychiatric disorders. Cortical paired associative stimulation (cPAS) is a form of transcranial magnetic stimulation in which paired pulses can induce plasticity at cortical synapses. Here we used cPAS pr...

journal_title：Biological psychiatry

authors： Kohl S,Hannah R,Rocchi L,Nord CL,Rothwell J,Voon V

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) is a noninvasive procedure that may be used to study individual differences in motor cortex excitability. Such differences are assumed to reflect serotonergic and other inputs to the motor cortex. METHODS:Here we investigate the impact of a functional polymorphism in ...

journal_title：Biological psychiatry

authors： Langguth B,Sand P,Marek R,Landgrebe M,Frank E,Hajak G,Eichhammer P

更新日期：2009-08-01 00:00:00

abstract：:Treatment-resistant depression (TRD) continues to represent a major challenge for treating clinicians. This report reviews the relevant literature to evaluate whether TRD can be considered a specific subtype of depression based on 1) clinical characteristics and course (behavioral phenotype), 2) neurobiological profil...

journal_title：Biological psychiatry

authors： Fagiolini A,Kupfer DJ

更新日期：2003-04-15 00:00:00

abstract：:Rhesus mother-infant pairs were housed in a playpen apparatus beginning just before the birth of four male infants. The infants were separated from their mothers four times beginning at a mean age of 218 days. In Type A separations (I and IV) the infants were removed and housed away from their familiar environment in ...

journal_title：Biological psychiatry

authors： Chappell PF,Meier GW

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:A recent analysis of 25 historical candidate gene polymorphisms for schizophrenia in the largest genome-wide association study conducted to date suggested that these commonly studied variants were no more associated with the disorder than would be expected by chance. However, the same study identified other ...

journal_title：Biological psychiatry

authors： Johnson EC,Border R,Melroy-Greif WE,de Leeuw CA,Ehringer MA,Keller MC

更新日期：2017-11-15 00:00:00

abstract：:Direct current potentials measured on the scalp suprajacent to the midline prefrontal cortex appear to monitor the metabolic activity, via CO2 production, of this portion of the cerebrum. Changes in the frontal potential 90 min after oral administration of 2.0 g L-tryptophan and of 50 mg cortisol were studied in group...

journal_title：Biological psychiatry

authors： Cowen MA

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:Degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in the brain, occurs early and is ubiquitous in Alzheimer's disease (AD). Experimental lesions to the LC exacerbate AD-like neuropathology and cognitive deficits in several transgenic mouse models of AD. Because the LC contains multipl...

journal_title：Biological psychiatry

authors： Hammerschmidt T,Kummer MP,Terwel D,Martinez A,Gorji A,Pape HC,Rommelfanger KS,Schroeder JP,Stoll M,Schultze J,Weinshenker D,Heneka MT

更新日期：2013-03-01 00:00:00

abstract：:Olfactory sensitivity to two odorants, isoamyl acetate and androsterone, was assessed in 14 obsessive compulsive disorder (OCD) patients, nine major depressive disorder (MDD) patients, and 16 sex- and age-matched healthy controls. Tests were performed during a drug-free period, and 3 and 6 weeks after initiation of an...

journal_title：Biological psychiatry

authors： Gross-Isseroff R,Luca-Haimovici K,Sasson Y,Kindler S,Kotler M,Zohar J

更新日期：1994-05-15 00:00:00

abstract：:Eleven healthy men were confined in a metabolic research unit for 120 days in a double-blind study of the effects of dietary selenium on mood as assessed by the Profile of Mood States-Bipolar Form. At an intake of 2800 kcal/day, the diet of conventional foods provided 80 micrograms/day of selenium for the first 21 day...

journal_title：Biological psychiatry

authors： Hawkes WC,Hornbostel L

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:Depression is a complex neuropsychiatric syndrome that is often very severe and life threatening. In spite of the remarkable progress in understanding the neural biology, the etiopathophysiology of depression is still elusive. In this study, we have investigated molecular mechanisms in the prefrontal cortex ...

journal_title：Biological psychiatry

authors： Veeraiah P,Noronha JM,Maitra S,Bagga P,Khandelwal N,Chakravarty S,Kumar A,Patel AB

更新日期：2014-08-01 00:00:00

abstract：:Auditory evoked potentials were recorded using a paired click, conditioning-testing paradigm in 10 schizophrenics and in 10 normal subjects with no family history of psychotic disorder. The paradigm is used to demonstrate central nervous system gating of responsiveness to auditory stimuli by examining the extent to wh...

journal_title：Biological psychiatry

authors： Nagamoto HT,Adler LE,Waldo MC,Freedman R

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Prior studies using simple target detection ("oddball") tasks with pure tones have reported asymmetric reduction of the P3 event-related potential (ERP). This study investigated the time course and topography of ERPs recorded during both tonal and phonetic oddball tasks. METHODS:Event-related potentials of ...

journal_title：Biological psychiatry

authors： Kayser J,Bruder GE,Tenke CE,Stuart BK,Amador XF,Gorman JM

更新日期：2001-05-15 00:00:00

abstract：:To examine directly in the brain the status of the alpha 2-adrenoceptor in major depression, the specific binding of the agonists [3H]clonidine and [3H]UK 14304 was quantitated in various brain regions of suicide victims with a retrospective diagnosis of depression or other psychiatric disorders. In depressed suicides...

journal_title：Biological psychiatry

authors： Meana JJ,Barturen F,García-Sevilla JA

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:A method that promotes the retrieval of lost long-term memories has not been well established. Histamine in the central nervous system is implicated in learning and memory, and treatment with antihistamines impairs learning and memory. Because histamine H3 receptor inverse agonists upregulate histamine relea...

journal_title：Biological psychiatry

authors： Nomura H,Mizuta H,Norimoto H,Masuda F,Miura Y,Kubo A,Kojima H,Ashizuka A,Matsukawa N,Baraki Z,Hitora-Imamura N,Nakayama D,Ishikawa T,Okada M,Orita K,Saito R,Yamauchi N,Sano Y,Kusuhara H,Minami M,Takahashi H,Ikeg

更新日期：2019-08-01 00:00:00

abstract：:Psychomotor retardation is a frequently observed clinical feature of depressive states. This study attempted to assess the relationship between response slowness and central nervous system (CNS) activity by examining cortical evoked potentials (EPs) during psychomotor task performance. Patients consisted of 21 women w...

journal_title：Biological psychiatry

authors： Knott VJ,Lapierre YD

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:The development of adaptive implicit and explicit emotion regulation skills is crucial for mental health. Adolescence and emerging adulthood are periods of heightened risk for psychopathology associated with emotion dysregulation, and neurodevelopmental mechanisms have been proposed to account for this incre...

journal_title：Biological psychiatry

authors： Pozzi E,Vijayakumar N,Rakesh D,Whittle S

更新日期：2021-01-15 00:00:00

abstract：:Somatostatin is a tetradecapeptide that is assuming increasing importance as a regulator of central nervous system activity. Originally identified as the hypothalamic growth hormone release-inhibiting factor, somatostatin has subsequently been shown to be extensively and selectively distributed throughout the central ...

journal_title：Biological psychiatry

authors： Rubinow DR

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:There is evidence that vascular factors contribute substantially to Alzheimer's disease (AD). We have developed assays to reliably detect the circulation and microcirculation regulating factors C-terminal endothelin-1 precursor fragment (CT-proET-1), midregional pro-adrenomedullin (MR-proADM), and midregiona...

journal_title：Biological psychiatry

authors： Buerger K,Ernst A,Ewers M,Uspenskaya O,Omerovic M,Morgenthaler NG,Knauer K,Bergmann A,Hampel H

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:A large number of studies suggest the presence of deficits in dorsolateral prefrontal cortex function during performance of working memory tasks in individuals with schizophrenia. However, working memory deficits may also present in other psychiatric disorders, such as major depression. It is not clear wheth...

journal_title：Biological psychiatry

authors： Barch DM,Sheline YI,Csernansky JG,Snyder AZ

更新日期：2003-03-01 00:00:00

abstract：:This paper discusses the current practice of using single word labels for emotional states that ignore the nature of the incentive, cognitive representations, physiologic profile, and especially the developmental stage of the agent. The universal cognitive advances that are derivatives of brain maturation over the fir...

journal_title：Biological psychiatry

authors： Kagan J

更新日期：2001-06-15 00:00:00

abstract：BACKGROUND:Prior neurophysiological studies on patients with premenstrual syndrome (PMS) have revealed sleep electroencephalographic alterations in both cycle phases. We report on a study evaluating saccadic eye movements in PMS patients. METHODS:Saccadic eye movements were examined in 21 women with and 21 women witho...

journal_title：Biological psychiatry

authors： Sundström I,Bäckström T

更新日期：1998-10-15 00:00:00

abstract：BACKGROUND:The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females. METHODS:We described brain growth trajectories in 55 girls with TS and...

journal_title：Biological psychiatry

authors： O'Donoghue S,Green T,Ross JL,Hallmayer J,Lin X,Jo B,Huffman LC,Hong DS,Reiss AL

更新日期：2020-01-15 00:00:00