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Proton magnetic resonance spectroscopy of human basal ganglia: response to cocaine administration.

Abstract：

BACKGROUND:Proton magnetic resonance spectroscopy was used to determine the effects of intravenous cocaine or placebo administration on human basal ganglia water and metabolite resonances. METHODS:Long echo time, proton magnetic resonance spectra of water and intracellular metabolites were continuously acquired from an 8-cm(3) voxel centered on the left caudate and putamen nuclei before, during, and after the intravenous administration of cocaine or a placebo in a double-blind manner. RESULTS:Cocaine, at both 0.2 and 0.4 mg/kg, did not alter the peak area for water. Cocaine at 0.2 mg/kg induced small and reversible increases in choline-containing compounds and N-acetylaspartate peak areas. Cocaine at 0.4 mg/kg induced larger and more sustained increases in choline-containing compounds and N-acetylaspartate peak areas. No changes in either water or metabolite resonances were noted following placebo administration. CONCLUSIONS:These increases in choline-containing compounds and N-acetylaspartate peak areas may reflect increases in metabolite T2 relaxation times secondary to osmotic stress and/or increased phospholipid signaling within the basal ganglia following cocaine administration. This is the first report of acute, drug-induced changes in the intensity of human brain proton magnetic resonance spectroscopy resonance areas.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Christensen JD,Kaufman MJ,Frederick B,Rose SL,Moore CM,Lukas SE,Mendelson JH,Cohen BM,Renshaw PF

doi

10.1016/s0006-3223(00)00897-0

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

685-92

issue

7

eissn

0006-3223

issn

1873-2402

pii

S0006322300008970

journal_volume

48

pub_type

临床试验,杂志文章

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