当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.

Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.

Abstract：

BACKGROUND:Exploiting synteny between mouse and human disease loci has been proposed as a cost-effective method for the identification of human susceptibility genes. Here we explore its utility in an analysis of a human personality trait, neuroticism, which can be modeled in mice by tests of emotionality. We investigated a mouse emotionality locus on chromosome 1 that contains no annotated genes but abuts four regulators of G protein signaling, one of which (rgs2) has been previously identified as a quantitative trait gene for emotionality. This locus is syntenic with a human region that has been consistently implicated in the genetic aetiology of neuroticism. METHODS:The functional candidacy of 29 murine sequence variants was tested by a combination of gel shift and transient transfection assays. Murine sequences that contained functional variants and exhibited significant cross-species conservation were prioritized for investigation in humans. Genetic association with neuroticism was tested in 1869 high and 2032 low unrelated individuals scored for neuroticism, selected from the extremes of 88,141 people from southwest England. RESULTS:Fifteen sequence variants contributed to variation in the expression of rgs18, the gene lying at the edge of the quantitative trait loci (QTL) interval. There was no evidence of association between neuroticism and single nucleotide polymorphisms (SNPs) lying in the human regions homologous to those of mouse functional variants. One SNP, rs6428058, in a region of sequence conservation 644 kb upstream of RGS18, showed significant association (p = .000631). CONCLUSIONS:It is unlikely that a single variant is responsible for the mouse emotionality locus on chromosome 1. This level of underlying genetic complexity means that although cross-species QTL concordance may be invaluable for the identification of human disease loci, it is unlikely to be as informative in the identification of human disease-causing variants.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Fullerton JM,Willis-Owen SA,Yalcin B,Shifman S,Copley RR,Miller SR,Bhomra A,Davidson S,Oliver PL,Mott R,Flint J

doi

10.1016/j.biopsych.2007.10.019

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

874-83

issue

9

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(07)01047-5

journal_volume

63

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Decreased receptor-binding sites for kainic acid in brains of patients with Huntington's disease.

    abstract：:The specific binding of (3H)kainic acid (KA) to high- and low-affinity receptor sites was assayed in postmortem samples from the brains of patients affected with Huntington's disease (HD) and age-matched controls. Treatment of rat brain with conditions that closely mimic the temperature gradient occurring in postmorte...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： London ED,Yamamura HI,Bird ED,Coyle JT

    更新日期：1981-02-01 00:00:00

  • Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.

    abstract：BACKGROUND:Antenatal maternal cortisol levels associate with alterations in the amygdala, a structure associated with emotion regulation, in the offspring. However, because offspring brain and behavior are commonly assessed years after birth, the timing of such maternal influences is unclear. This study aimed to examin...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.06.019

    authors： Rifkin-Graboi A,Bai J,Chen H,Hameed WB,Sim LW,Tint MT,Leutscher-Broekman B,Chong YS,Gluckman PD,Fortier MV,Meaney MJ,Qiu A

    更新日期：2013-12-01 00:00:00

  • An inflammatory pathway links atherosclerotic cardiovascular disease risk to neural activity evoked by the cognitive regulation of emotion.

    abstract：BACKGROUND:Cognitive reappraisal is a form of emotion regulation that alters emotional responding by changing the meaning of emotional stimuli. Reappraisal engages regions of the prefrontal cortex that support multiple functions, including visceral control functions implicated in regulating the immune system. Immune ac...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.10.012

    authors： Gianaros PJ,Marsland AL,Kuan DC,Schirda BL,Jennings JR,Sheu LK,Hariri AR,Gross JJ,Manuck SB

    更新日期：2014-05-01 00:00:00

  • Reduction of orbital frontal cortex volume in geriatric depression.

    abstract：BACKGROUND:Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging. METHODS:Twenty elderly patients meeting DSM-IV criteria for m...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(00)01042-8

    authors： Lai T,Payne ME,Byrum CE,Steffens DC,Krishnan KR

    更新日期：2000-11-15 00:00:00

  • Smooth-pursuit eye movement and saccadic intrusions in obsessive-compulsive disorder.

    abstract：:Although several reports agree that smooth-pursuit eye movement (SPEM) is abnormal in some obsessive-compulsive disordered (OCD) patients, differences between treatments and lack of accuracy in control selection make the results controversial. Although reduced gain seems the most accepted abnormality, the characterist...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(95)00607-9

    authors： Pallanti S,Grecu LM,Gangemi PF,Massi S,Parigi A,Arnetoli G,Quercioli L,Zaccara G

    更新日期：1996-12-01 00:00:00

  • Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans.

    abstract：BACKGROUND:The neurofibromatosis type 1 (Nf1) gene encodes a GTPase activating protein that negatively regulates small GTPases of the Ras family. METHODS:We assessed alcohol-related behaviors including alcohol sensitivity, dependent and nondependent drinking, and basal and alcohol-induced gamma-aminobutyric acid (GABA...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.07.031

    authors： Repunte-Canonigo V,Herman M,Kawamura T,Kranzler HR,Sherva R,Gelernter J,Farrer LA,Roberto M,Sanna PP

    更新日期：2015-05-15 00:00:00

  • Dopaminergic function in panic disorder: comparison with major and minor depression.

    abstract：:Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-m...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90061-4

    authors： Pitchot W,Ansseau M,Gonzalez Moreno A,Hansenne M,von Frenckell R

    更新日期：1992-12-01 00:00:00

  • Analysis of heart rate variability in posttraumatic stress disorder patients in response to a trauma-related reminder.

    abstract：BACKGROUND:Spectral analysis of heart rate variability has recently been shown to be a reliable noninvasive test for quantitative assessment of cardiovascular autonomic regulatory responses, providing a dynamic map of sympathetic and parasympathetic interaction. In a prior study exploring the state of hyperarousal char...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(97)00475-7

    authors： Cohen H,Kotler M,Matar MA,Kaplan Z,Loewenthal U,Miodownik H,Cassuto Y

    更新日期：1998-11-15 00:00:00

  • Caffeine-induced anxiety and increase of kynurenine concentration in plasma of healthy subjects: a pilot study.

    abstract：:The concentration of kynurenine, a neuroactive tryptophan metabolite, in blood plasma after pharmacologically induced anxiety was studied. Anxiety was provoked in 15 healthy volunteers by an anxiogenic dose of caffeine. Kynurenine concentration was markedly increased at the peak of anxiety and returned to normal after...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90225-b

    authors： Orlikov A,Ryzov I

    更新日期：1991-02-15 00:00:00

  • Brain Development in School-Age and Adolescent Girls: Effects of Turner Syndrome, Estrogen Therapy, and Genomic Imprinting.

    abstract：BACKGROUND:The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females. METHODS:We described brain growth trajectories in 55 girls with TS and...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2019.07.032

    authors： O'Donoghue S,Green T,Ross JL,Hallmayer J,Lin X,Jo B,Huffman LC,Hong DS,Reiss AL

    更新日期：2020-01-15 00:00:00

  • The monoamine oxidase-A gene and major psychosis in Japanese subjects.

    abstract：BACKGROUND:Monoamine oxidase (MAO) is a critical enzyme in deamination of biogenic amines and may be involved in the pathophysiology of major psychosis, including mood disorder and schizophrenia. Recently, evidence for genetic association between the MAO-A gene and bipolar mood disorder was obtained in Caucasians. MET...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(97)00522-2

    authors： Sasaki T,Hattori M,Sakai T,Kato T,Kunugi H,Hirose T,Nanko S

    更新日期：1998-11-01 00:00:00

  • Calcium channel blockade interacts with a neuroleptic to attenuate the conditioning of amphetamine's behavioral effects in the rat.

    abstract：:Conditioned responses to drug-related cues appear to be related to the maintenance of stimulant addiction. These conditioned responses are not blocked by treatments that block the direct effects of stimulants and may contribute to the high rate of relapse of addicts. Rats administered (+)-amphetamine in a specific env...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90159-w

    authors： DiLullo SL,Martin-Iverson MT

    更新日期：1992-06-01 00:00:00

  • Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures.

    abstract：:Injection of ferric chloride (FC) into the left amygdala of rats produced limbic seizures that lasted at least 3 weeks. In addition, FC-injected animals demonstrated motor impairment, decreased protesting vocalizations, and spontaneous stereotypies during a behavioral examination. An increase in apomorphine-induced st...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(85)90151-9

    authors： Csernansky JG,Csernansky CA,Bonnet KA,Hollister LE

    更新日期：1985-07-01 00:00:00

  • Family psychiatric history, cerebrospinal fluid monoamine metabolites, and temperament in infants.

    abstract：BACKGROUND:Variations in cerebrospinal fluid (CSF) levels of the monoamine metabolites 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, and homovanillic acid have been associated with behavioral abnormalities in nonhuman primates, and with psychopathology in studies of children and adults. METHODS:We assay...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00170-x

    authors： Constantino JN,Murphy DL,Morris JA

    更新日期：1999-03-01 00:00:00

  • Benzodiazepine derivatives--side effects and dangers.

    abstract：:The benzodiazepines are generally safe and effective drugs with usually only minor side effects, dose-related sedation being the most common. A range of paradoxical effects can occur of which release of aggressive and hostile feelings has excited most attention. These responses are idiosyncratic however, as most patie...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Lader MH,Petursson H

    更新日期：1981-12-01 00:00:00

  • Heart period and variability findings in preschool children with posttraumatic stress symptoms.

    abstract：BACKGROUND:Traumatic experiences for young children might result in profound neurodevelopmental changes, compared with adults. Our aim was to examine autonomic control of heart rate in traumatized young children. METHODS:Sixty-two children who had suffered traumas and 62 nontraumatized control children, aged 20 months...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.01.006

    authors： Scheeringa MS,Zeanah CH,Myers L,Putnam F

    更新日期：2004-04-01 00:00:00

  • Brain serotonin 1A receptor binding in bulimia nervosa.

    abstract：BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the first choice for the pharmacologic treatment of bulimia nervosa, but there are no published data on the putative altered serotonin (5-HT) receptor characteristics in patients with bulimia. Experimental studies suggest that the therapeutic antidepressant...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2003.12.016

    authors： Tiihonen J,Keski-Rahkonen A,Löppönen M,Muhonen M,Kajander J,Allonen T,Någren K,Hietala J,Rissanen A

    更新日期：2004-04-15 00:00:00

  • Partial inhibition by lithium of the epinephrine-stimulated rise in plasma cyclic GMP in humans.

    abstract：:Lithium-treated and drug-free individuals were each given 0.5 mg epinephrine subcutaneously and blood samples withdrawn for measurement of plasma cyclic AMP and cyclic GMP. The rise in plasma cyclic GMP in response to epinephrine was found to be partially inhibited by lithium treatment, and previous reports of lithium...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Belmaker RH,Kon M,Ebstein RP,Dasberg H

    更新日期：1980-02-01 00:00:00

  • Three and six-month outcome following courses of either ECT or rTMS in a population of severely depressed individuals--preliminary report.

    abstract：BACKGROUND:Recent studies have strengthened the claim that repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depression. The longitudinal outcome of TMS-treated patients, however, has not been described. We report on the 3- and 6-month outcomes of a group of patients treated with e...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-3223(01)01274-4

    authors： Dannon PN,Dolberg OT,Schreiber S,Grunhaus L

    更新日期：2002-04-15 00:00:00

  • Personality traits are differentially associated with patterns of reward and novelty processing in the human substantia nigra/ventral tegmental area.

    abstract：BACKGROUND:The long-standing observation that the novelty-seeking personality trait is a predictor of drug use and other reinforcable risky behaviors raises the question as to how novelty and reward processing functionally interact in mesolimbic dopaminergic circuitry and how this interaction is modulated by the novelt...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.08.019

    authors： Krebs RM,Schott BH,Düzel E

    更新日期：2009-01-15 00:00:00

  • Clinical predictors of relapse following neuroleptic withdrawal.

    abstract：:The validity of previously hypothesized predictors of elapse following neuroleptic discontinuation was examined. One hundred sixty-two outpatients, with either Research Diagnostic Criteria schizophrenia or schizoaffective disorder, were discontinued from neuroleptic medication for a 28-day period or until judged to be...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90143-n

    authors： Buchanan RW,Kirkpatrick B,Summerfelt A,Hanlon TE,Levine J,Carpenter WT Jr

    更新日期：1992-07-01 00:00:00

  • Autism and nonsyndromic mental retardation associated with a de novo mutation in the NLGN4X gene promoter causing an increased expression level.

    abstract：BACKGROUND:Pathogenic mutations in the X-linked Neuroligin 4 gene (NLGN4X) in autism spectrum disorders (ASDs) and/or mental retardation (MR) are rare. However, nothing is known regarding a possible altered expression level of NLGN4X that would be caused by mutations in regulatory sequences. We investigated this issue ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.05.008

    authors： Daoud H,Bonnet-Brilhault F,Védrine S,Demattéi MV,Vourc'h P,Bayou N,Andres CR,Barthélémy C,Laumonnier F,Briault S

    更新日期：2009-11-15 00:00:00

  • Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease.

    abstract：:It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal events. It is clear that the interaction between genetic predisposition and early life environment...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2018.06.014

    authors： Codagnone MG,Spichak S,O'Mahony SM,O'Leary OF,Clarke G,Stanton C,Dinan TG,Cryan JF

    更新日期：2019-01-15 00:00:00

  • Effects of dietary selenium on mood in healthy men living in a metabolic research unit.

    abstract：:Eleven healthy men were confined in a metabolic research unit for 120 days in a double-blind study of the effects of dietary selenium on mood as assessed by the Profile of Mood States-Bipolar Form. At an intake of 2800 kcal/day, the diet of conventional foods provided 80 micrograms/day of selenium for the first 21 day...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0006-3223(95)00085-2

    authors： Hawkes WC,Hornbostel L

    更新日期：1996-01-15 00:00:00

  • Evidence against linkage of schizophrenia to chromosome 5q11-q13 markers in systematically ascertained families.

    abstract：:Ten pedigrees systematically ascertained in Germany were tested for linkage to chromosome 5q11-q13. In order to replicate the previous report by Sherrington et al (1988), families with a bipolar family member were omitted from the lod score calculations, all diagnoses were based upon Research Diagnostic Criteria, and ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90008-n

    authors： Hallmayer J,Maier W,Ackenheil M,Ertl MA,Schmidt S,Minges J,Lichtermann D,Wildenauer D

    更新日期：1992-01-01 00:00:00

  • Serotonin transporter polymorphism moderates effects of prenatal maternal anxiety on infant negative emotionality.

    abstract：BACKGROUND:Consistent with the fetal programming hypothesis, effects of maternal prenatal anxiety have been found to predict various measures of infant temperament in the early postnatal period. In recent years, a polymorphism in the serotonin transporter gene (5-HTTLPR) emerged as a moderator of diverse environmental ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.10.006

    authors： Pluess M,Velders FP,Belsky J,van IJzendoorn MH,Bakermans-Kranenburg MJ,Jaddoe VW,Hofman A,Arp PP,Verhulst FC,Tiemeier H

    更新日期：2011-03-15 00:00:00

  • The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases.

    abstract：BACKGROUND:We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment. METHODS:In this multicenter, double-blind study, outpatients with recurrent unipolar major depression were randomly assigned to receive venlafaxine ER (75-3...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.biopsych.2007.04.040

    authors： Keller MB,Trivedi MH,Thase ME,Shelton RC,Kornstein SG,Nemeroff CB,Friedman ES,Gelenberg AJ,Kocsis JH,Dunner DL,Dunlop BW,Hirschfeld RM,Rothschild AJ,Ferguson JM,Schatzberg AF,Zajecka JM,Pedersen R,Yan B,Ahmed S,Schm

    更新日期：2007-12-15 00:00:00

  • Effects of changes in carbon dioxide tension in abnormally prolonged contingent negative variation (CNV).

    abstract：:The effects of changes in pCO2 in the development and resolution of normal (return to base line within 2 sec after S2) and abnormal (return to base line in more than 2 sec after S2) CNVs were studied. Decreased pCO2 produced by hyperventilation induced a significant reduction in the duration of the post-imperative neg...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Dubrovsky B,Garcia-Rill E,Simkus R,Dongier M

    更新日期：1976-10-01 00:00:00

  • Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk.

    abstract：BACKGROUND:The implication of serotonin in suicide and affective disease explains why the 5-HT(2A) receptor gene has been proposed as a candidate gene in these disorders, although with conflicting results. METHODS:We analysed the distribution of the 5-HT(2A)-1438A/G genetic polymorphism in 192 patients with major affe...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(01)01228-8

    authors： Bonnier B,Gorwood P,Hamon M,Sarfati Y,Boni C,Hardy-Bayle MC

    更新日期：2002-05-01 00:00:00

  • Perfusion abnormalities and decision making in cocaine dependence.

    abstract：BACKGROUND:Previous studies have shown that cocaine abusers have cerebral perfusion deficits that may diminish cognitive functioning. This study examined whether cocaine-dependent patients have perfusion abnormalities associated with poor decision-making ability as measured by the Iowa Gambling Task (IGT). METHODS:Sev...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.biopsych.2004.06.031

    authors： Tucker KA,Potenza MN,Beauvais JE,Browndyke JN,Gottschalk PC,Kosten TR

    更新日期：2004-10-01 00:00:00