当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability.

Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability.

Abstract：

BACKGROUND:Marijuana use by teenagers often predates the use of harder drugs, but the neurobiological underpinnings of such vulnerability are unknown. Animal studies suggest enhanced heroin self-administration (SA) and dysregulation of the endogenous opioid system in the nucleus accumbens shell (NAcsh) of adults following adolescent Δ(9)-tetrahydrocannabinol (THC) exposure. However, a causal link between proenkephalin (Penk) expression and vulnerability to heroin has yet to be established. METHODS:To investigate the functional significance of NAcsh Penk tone, selective viral-mediated knockdown and overexpression of Penk was performed, followed by analysis of subsequent heroin SA behavior. To determine whether adolescent THC exposure was associated with chromatin alteration, we analyzed levels of histone H3 methylation in the NAcsh via chromatin immunoprecipitation at five sites flanking the Penk gene transcription start site. RESULTS:Here we show that regulation of the Penk opioid neuropeptide gene in NAcsh directly regulates heroin SA behavior. Selective viral-mediated knockdown of Penk in striatopallidal neurons attenuates heroin SA in adolescent THC-exposed rats, whereas Penk overexpression potentiates heroin SA in THC-naïve rats. Furthermore, we report that adolescent THC exposure mediates Penk upregulation through reduction of histone H3 lysine 9 (H3K9) methylation in the NAcsh, thereby disrupting the normal developmental pattern of H3K9 methylation. CONCLUSIONS:These data establish a direct association between THC-induced NAcsh Penk upregulation and heroin SA and indicate that epigenetic dysregulation of Penk underlies the long-term effects of THC.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Tomasiewicz HC,Jacobs MM,Wilkinson MB,Wilson SP,Nestler EJ,Hurd YL

doi

10.1016/j.biopsych.2012.04.026

subject

Has Abstract

pub_date

2012-11-15 00:00:00

pages

803-10

issue

10

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(12)00409-X

journal_volume

72

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Multiple fixed doses of "Seroquel" (quetiapine) in patients with acute exacerbation of schizophrenia: a comparison with haloperidol and placebo. The Seroquel Trial 13 Study Group.

    abstract：:Five fixed doses of the atypical antipsychotic "Seroquel" (quetiapine) were evaluated to delineate a dose-response relationship, as measured by changes from baseline in Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression (CGI), and Modified Scale for the Assessment of Negative Symptoms (SANS) summary sco...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0006-3223(97)00190-x

    authors： Arvanitis LA,Miller BG

    更新日期：1997-08-15 00:00:00

  • Effect of alcoholism on the incidence of lactate-induced panic attacks.

    abstract：BACKGROUND:Chronic alcohol use is associated with higher than expected rates of panic disorder. METHODS:To study the relationship between alcoholism and panic disorder, we administered the panicogenic agent, sodium lactate, to 26 alcoholics with either panic disorder or frequent panic attacks (ALCPAN), 20 nonalcoholic...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(97)00008-5

    authors： George DT,Lindquist T,Ragan PW,Alim T,Eckardt MJ,Linnoila M

    更新日期：1997-12-01 00:00:00

  • Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients.

    abstract：:Disturbances in dopaminergic transmission have been implicated in the etiology of psychotic disorders. Interindividual differences in deoxyribonucleic acid (DNA) sequences coding for dopamine receptor proteins might contribute to the genetic background of these diseases. We have identified a variation in exon 1 of the...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(93)90236-7

    authors： Catalano M,Nobile M,Novelli E,Nöthen MM,Smeraldi E

    更新日期：1993-10-01 00:00:00

  • Leptin regulates energy balance and motivation through action at distinct neural circuits.

    abstract：BACKGROUND:Overconsumption of calorically dense foods contributes substantially to the current obesity epidemic. The adiposity hormone leptin has been identified as a potential modulator of reward-induced feeding. The current study asked whether leptin signaling within the lateral hypothalamus (LH) and midbrain is invo...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.08.028

    authors： Davis JF,Choi DL,Schurdak JD,Fitzgerald MF,Clegg DJ,Lipton JW,Figlewicz DP,Benoit SC

    更新日期：2011-04-01 00:00:00

  • Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.

    abstract：BACKGROUND:Neurocognitive deficits are recognized as a cardinal feature of schizophrenia, but the determinants of these deficits remain unknown. Recent reports have suggested that a functional polymorphism, Val(158)Met in exon III of the catechol-O-methyltransferase gene, shares approximately 4% variance with performan...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01416-6

    authors： Bilder RM,Volavka J,Czobor P,Malhotra AK,Kennedy JL,Ni X,Goldman RS,Hoptman MJ,Sheitman B,Lindenmayer JP,Citrome L,McEvoy JP,Kunz M,Chakos M,Cooper TB,Lieberman JA

    更新日期：2002-10-01 00:00:00

  • Subsensitivity of adenylyl cyclase-coupled receptors on mononuclear leukocytes from drug-free inpatients with a major depressive episode.

    abstract：:Previous studies have demonstrated blunted beta-adrenergic responsivity in leukocytes from depressed patients. We sought to determine if this blunted cyclic adenosine monophosphate (AMP) response is specific for beta-adrenergic receptors (homologous), or whether other adenylyl cyclase-coupled receptors are also involv...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0006-3223(97)00154-6

    authors： Mann JJ,Halper JP,Wilner PJ,Sweeney JA,Mieczkowski TA,Chen JS,Stokes PE,Brown RP

    更新日期：1997-11-15 00:00:00

  • Unaffected family members and schizophrenia patients share brain structure patterns: a high-dimensional pattern classification study.

    abstract：BACKGROUND:A number of studies have provided evidence for genetic modulation of brain structure in unaffected family members (FM) of schizophrenia patients using conventional volumetric analysis. High-dimensional pattern classification methods have been reported to have the capacity to determine subtle and spatially co...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2007.03.015

    authors： Fan Y,Gur RE,Gur RC,Wu X,Shen D,Calkins ME,Davatzikos C

    更新日期：2008-01-01 00:00:00

  • Neural responses to monetary incentives in major depression.

    abstract：BACKGROUND:Reduced responsiveness to positive incentives is a central feature of Major Depressive Disorder (MDD). In the present study, we compared neural correlates of monetary incentive processing in unmedicated depressed participants and never-depressed control subjects. METHODS:Fourteen currently depressed and 12 ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2007.07.023

    authors： Knutson B,Bhanji JP,Cooney RE,Atlas LY,Gotlib IH

    更新日期：2008-04-01 00:00:00

  • A meta-analysis of the corpus callosum in autism.

    abstract：BACKGROUND:Previous magnetic resonance imaging (MRI) studies have reported reductions in corpus callosum (CC) total area and CC regions in individuals with autism. However, studies have differed concerning the magnitude and/or region contributing to CC reductions. The present study determined the significance and magni...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.biopsych.2009.07.022

    authors： Frazier TW,Hardan AY

    更新日期：2009-11-15 00:00:00

  • Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis.

    abstract：:The aberrant salience hypothesis proposes that striatal dopamine dysregulation causes misattribution of salience to irrelevant stimuli leading to psychosis. Recently, new lines of preclinical evidence on information coding by subcortical dopamine coupled with computational models of the brain's ability to predict and ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2020.03.012

    authors： Howes OD,Hird EJ,Adams RA,Corlett PR,McGuire P

    更新日期：2020-08-15 00:00:00

  • Cumulative alterations in rat behavior during continuous administration of LSD or mescaline: absence of tolerance?

    abstract：:Male hooded rats were observed for 6 days following implantation with slow-release subcutaneous pellets containing LSD, mescaline, or control vehicle solution. In animals housed in isolation cages, continuous hallucinogen administration resulted in a gradual increase in head twitches and catatonic postures which peake...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Ellison G,Ring M,Ross D,Axelrood B

    更新日期：1980-02-01 00:00:00

  • Chronic stress causes amygdala hyperexcitability in rodents.

    abstract：BACKGROUND:Chronic stress is a major health concern, often leading to depression, anxiety, or when severe enough, posttraumatic stress disorder. While many studies demonstrate that the amygdala is hyperresponsive in patients with these disorders, the cellular neurophysiological effects of chronic stress on the systems ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.02.008

    authors： Rosenkranz JA,Venheim ER,Padival M

    更新日期：2010-06-15 00:00:00

  • Ziskind-Somerfeld Research Award 1996. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder.

    abstract：:Prior magnetic resonance imaging (MRI) studies report both medial and lateral cortical temporal changes and disturbed temporal lobe asymmetries in schizophrenic patients compared with healthy controls. The specificity of temporal lobe (TL) changes in schizophrenia is unknown. We determined the occurrence and specifici...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(96)00373-3

    authors： Pearlson GD,Barta PE,Powers RE,Menon RR,Richards SS,Aylward EH,Federman EB,Chase GA,Petty RG,Tien AY

    更新日期：1997-01-01 00:00:00

  • Is treatment-resistant depression a unique subtype of depression?

    abstract：:Treatment-resistant depression (TRD) continues to represent a major challenge for treating clinicians. This report reviews the relevant literature to evaluate whether TRD can be considered a specific subtype of depression based on 1) clinical characteristics and course (behavioral phenotype), 2) neurobiological profil...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(02)01670-0

    authors： Fagiolini A,Kupfer DJ

    更新日期：2003-04-15 00:00:00

  • Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking.

    abstract：BACKGROUND:There is growing evidence that the dysregulation of circadian rhythms may play an important role in irregular sleep-waking in demented elderly. In this study, we investigated daily variation of the pineal hormone melatonin, which has been reported to possess hypnogenic and synchronizing effects, in patients ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(97)00510-6

    authors： Mishima K,Tozawa T,Satoh K,Matsumoto Y,Hishikawa Y,Okawa M

    更新日期：1999-02-15 00:00:00

  • Neonatal lesions of the ventral hippocampal formation alter GABA-A receptor subunit mRNA expression in adult rat frontal pole.

    abstract：BACKGROUND:Gamma-aminobutyric acid (GABA)-ergic function is altered in schizophrenia. Of particular interest is the altered central nervous system expression of GABA-A receptor subunits, as changes in subunit expression account for recognized differences in mammalian brain function making them inviting targets for nove...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.09.017

    authors： Mitchell CP,Grayson DR,Goldman MB

    更新日期：2005-01-01 00:00:00

  • Impaired Communication Between the Motor and Somatosensory Homunculus Is Associated With Poor Manual Dexterity in Autism Spectrum Disorder.

    abstract：BACKGROUND:Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting quality of life. Sensory inputs reaching the primary motor cortex (M1) from the somatosensory cortex (S1) are likely involved in fine motor skill and specifically motor learning. However, the role of these conn...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2016.06.020

    authors： Thompson A,Murphy D,Dell'Acqua F,Ecker C,McAlonan G,Howells H,Baron-Cohen S,Lai MC,Lombardo MV,MRC AIMS Consortium, and Marco Catani.

    更新日期：2017-02-01 00:00:00

  • The McLean-Harvard first-episode project: 6-month symptomatic and functional outcome in affective and nonaffective psychosis.

    abstract：BACKGROUND:The McLean-Harvard First-Episode Project recruited affective and nonaffective patients at their first lifetime psychiatric hospitalization. METHODS:Baseline evaluation and 6-month follow-up in 257 cases yielded recovery outcomes defined by syndromal (absence of DSM-IV criteria for a current episode) and fun...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(00)00915-x

    authors： Tohen M,Strakowski SM,Zarate C Jr,Hennen J,Stoll AL,Suppes T,Faedda GL,Cohen BM,Gebre-Medhin P,Baldessarini RJ

    更新日期：2000-09-15 00:00:00

  • Inflammatory Factors Mediate Vulnerability to a Social Stress-Induced Depressive-like Phenotype in Passive Coping Rats.

    abstract：BACKGROUND:Coping strategy impacts susceptibility to psychosocial stress. The locus coeruleus (LC) and dorsal raphe (DR) are monoamine nuclei implicated in stress-related disorders. Our goal was to identify genes in these nuclei that distinguish active and passive coping strategies in response to social stress. METHOD...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.10.026

    authors： Wood SK,Wood CS,Lombard CM,Lee CS,Zhang XY,Finnell JE,Valentino RJ

    更新日期：2015-07-01 00:00:00

  • Neuroanatomical Diversity of Corpus Callosum and Brain Volume in Autism: Meta-analysis, Analysis of the Autism Brain Imaging Data Exchange Project, and Simulation.

    abstract：BACKGROUND:Patients with autism have been often reported to have a smaller corpus callosum (CC) than control subjects. METHODS:We conducted a meta-analysis of the literature, analyzed the CC in 694 subjects of the Autism Brain Imaging Data Exchange project, and performed computer simulations to study the effect of dif...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.biopsych.2015.02.010

    authors： Lefebvre A,Beggiato A,Bourgeron T,Toro R

    更新日期：2015-07-15 00:00:00

  • Analysis of heart rate variability in posttraumatic stress disorder patients in response to a trauma-related reminder.

    abstract：BACKGROUND:Spectral analysis of heart rate variability has recently been shown to be a reliable noninvasive test for quantitative assessment of cardiovascular autonomic regulatory responses, providing a dynamic map of sympathetic and parasympathetic interaction. In a prior study exploring the state of hyperarousal char...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(97)00475-7

    authors： Cohen H,Kotler M,Matar MA,Kaplan Z,Loewenthal U,Miodownik H,Cassuto Y

    更新日期：1998-11-15 00:00:00

  • Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression.

    abstract：BACKGROUND:Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas, has been implicated in mood disorders such as major depression and anxiety. Within the 5-HT1A receptor gene, a powerful dual repressor element (DRE) is regulated ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.02.033

    authors： Hadjighassem MR,Austin MC,Szewczyk B,Daigle M,Stockmeier CA,Albert PR

    更新日期：2009-08-01 00:00:00

  • Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia.

    abstract：BACKGROUND:Generalized social phobia (gSP), also known as generalized social anxiety disorder, is characterized by excessive fear of scrutiny by others and pervasive avoidance of social interactions. Pathophysiologic models of gSP implicate exaggerated reactivity of the amygdala and insula in response to social evaluat...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.10.003

    authors： Phan KL,Coccaro EF,Angstadt M,Kreger KJ,Mayberg HS,Liberzon I,Stein MB

    更新日期：2013-02-15 00:00:00

  • Correlations of glutathione peroxidase activity with memory impairment in adults with Down syndrome.

    abstract：BACKGROUND:Down syndrome (DS) is a genetic disorder (trisomy 21 in 96% of cases), associated with an excess of a key enzyme involved with free radical metabolism (FRM), superoxide dismutase-1 (SOD-1), that is encoded by a gene on chromosome 21. Consequently, SOD-1 activity is elevated in DS, which also occurs in condit...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00026-8

    authors： Brugge K,Nichols S,Saitoh T,Trauner D

    更新日期：1999-12-15 00:00:00

  • Attention Alterations in Pediatric Anxiety: Evidence From Behavior and Neuroimaging.

    abstract：BACKGROUND:Pediatric anxiety disorders involve greater capture of attention by threatening stimuli. However, it is not known if disturbances extend to nonthreatening stimuli, as part of a pervasive disturbance in attention-related brain systems. We hypothesized that pediatric anxiety involves greater capture of attenti...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2020.07.016

    authors： Perino MT,Yu Q,Myers MJ,Harper JC,Baumel WT,Petersen SE,Barch DM,Luby JL,Sylvester CM

    更新日期：2020-08-01 00:00:00

  • Factors associated with duration of survival in Alzheimer's disease.

    abstract：:With a computerized data base, a data retrieval system, and a computer program using the actuarial method of life-table analysis, we compared survival rates in different subgroups of patients with dementia of the Alzheimer type (DAT; n = 199). Men (n = 71) had a shorter duration of survival than women (n = 128), with ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(85)90139-8

    authors： Barclay LL,Zemcov A,Blass JP,McDowell FH

    更新日期：1985-01-01 00:00:00

  • Striatal enlargement in rats chronically treated with neuroleptic.

    abstract：BACKGROUND:Striatal enlargement with chronic neuroleptic treatment in schizophrenic patients has been reported by several investigators. Longitudinal magnetic resonance imaging studies of patients suggest that changes in striatal volume may be caused by treatment with antipsychotic medication. METHODS:We have examined...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00029-8

    authors： Chakos MH,Shirakawa O,Lieberman J,Lee H,Bilder R,Tamminga CA

    更新日期：1998-10-15 00:00:00

  • Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders.

    abstract：BACKGROUND:Gastrointestinal (GI) symptoms and abnormalities in stool consistency are frequently reported by parents of children with autism spectrum disorders (ASD). The purpose of this study was to 1) describe dietary intake of a cohort of children with ASD compared with normative data and 2) determine whether GI symp...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2006.07.013

    authors： Levy SE,Souders MC,Ittenbach RF,Giarelli E,Mulberg AE,Pinto-Martin JA

    更新日期：2007-02-15 00:00:00

  • Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing's disease.

    abstract：BACKGROUND:Decreased hippocampal volume is observed in patients with Cushing's syndrome and other conditions associated with elevated cortisol levels, stress, or both. Reversibility of hippocampal neuronal atrophy resulting from stress occurs in animals. Our study investigated the potential for reversibility of human h...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(99)00203-6

    authors： Starkman MN,Giordani B,Gebarski SS,Berent S,Schork MA,Schteingart DE

    更新日期：1999-12-15 00:00:00

  • Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.

    abstract：BACKGROUND:Endocytic dysfunction and neurotrophin signaling deficits may underlie the selective vulnerability of hippocampal neurons during the progression of Alzheimer's disease (AD), although there is little direct in vivo and biochemical evidence to support this hypothesis. METHODS:Microarray analysis of hippocampa...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.05.030

    authors： Ginsberg SD,Alldred MJ,Counts SE,Cataldo AM,Neve RL,Jiang Y,Wuu J,Chao MV,Mufson EJ,Nixon RA,Che S

    更新日期：2010-11-15 00:00:00