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Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4).

Abstract：

:Both genetic and environmental factors have been associated with an increased risk for schizophrenia. These factors are not mutually exclusive; a single gene can be a genetic factor (due to a mutation in the gene sequence) and a target of a physiological response to an environmental stimulus, both with the common endpoint of altered expression of the gene. Regulator of G-protein signaling 4 (RGS4) has been implicated as such a gene from three lines of evidence. First, a subset of genetic studies revealed an association between schizophrenia and non-functional polymorphisms in the RGS4 gene. Second, across the cortical mantle the expression of RGS4 mRNA is decreased in a diagnosis-specific manner in subjects with schizophrenia. Third, neurobiological studies demonstrate that RGS4 is highly responsive to environmental stimuli and capable of modulating the function of G-protein coupled neurotransmitter receptors implicated in schizophrenia. RGS4 is an example of a molecule that may underlie increased vulnerability through either genetic or non-genetic mechanisms, which we suggest may be typical of other genes in a complex, polygenic disorder such as schizophrenia.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Levitt P,Ebert P,Mirnics K,Nimgaonkar VL,Lewis DA

doi

10.1016/j.biopsych.2006.04.028

subject

Has Abstract

pub_date

2006-09-15 00:00:00

pages

534-7

issue

6

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(06)00562-2

journal_volume

60

pub_type

杂志文章,评审

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