Abstract：
:Circling behavior is one of the best understood behaviors in animals. It is, for the most part, dopaminergically mediated and related to asymmetry in dopaminergic activity between the left and right basal ganglia or left and right frontal cortex. As a rule, animals rotate toward the hemisphere with lower striatal dopaminergic activity. A direct technique to find human analogs of circling behavior was not available. We have developed an automated rotometer with which we can apply the circling rodent model to humans. Left-prone circling behavior (neglect of right-sided turning) was found in 10 unmedicated schizophrenic patients, whereas 85 normal controls demonstrated almost equal right and left turning. These preliminary results may suggest the presence of a dopaminergic asymmetry in some unmedicated schizophrenic patients; that is, right anterior subcortical or cortical structures of the brain may manifest a relative dopaminergic overactivity compared to left anterior structures in at least some unmedicated patients with schizophrenia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Bracha HSdoi
10.1016/0006-3223(87)90009-6subject
Has Abstractpub_date
1987-08-01 00:00:00pages
995-1003issue
8eissn
0006-3223issn
1873-2402pii
0006-3223(87)90009-6journal_volume
22pub_type
杂志文章abstract：BACKGROUND:Major depressive disorder (MDD) in the adolescent demonstrates a unique clinical profile, and pathogenic serotonergic dysregulation is hypothesized. Parenteral clomipramine (CMI) is known to distinguish adult MDD from control, but neurochallenge data are lacking in adolescent MDD. METHODS:Thirteen drug-free...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(97)00447-2
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:The neural projections from the infralimbic region of the prefrontal cortex to the amygdala are important for the maintenance of conditioned fear extinction. Neurons in this pathway exhibit a unique pattern of structural plasticity that is sex-dependent, but the relationship between the morphologic character...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.11.014
更新日期：2015-08-01 00:00:00
abstract：:A 37-year-old female with Capgras syndrome was assessed on psychometric and neuropsychological measures. Significant neuropsychological deficits suggesting a frontal-temporal cerebral dysfunction were observed. The results demonstrate that the Capgras delusion involves more than an inability to recognize faces, althou...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：BACKGROUND:In view of the effects of stress on synaptic plasticity, the regulation of synaptophysin and synaptotagmin expression by immobilization was analyzed by in situ hybridization. METHODS:Rats were exposed to immobilization stress, which induced typical behavioral alterations, such as reduced locomotor activity ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01229-x
更新日期：2001-11-15 00:00:00
abstract：:EEG sleep measures in 35 depressed and 33 normal control adolescents were examined in relation to stressful life events occurring in the year before sleep studies. There was a significant interaction between stressful life events and diagnostic status for REM latency and total REM time. In the normal controls, the pre...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0006-3223(94)00240-4
更新日期：1995-06-15 00:00:00
abstract：:This paper reports the phenomenon of dependence to a somatostatin octapeptide analog used for the treatment of acromegaly and severe headache. The mechanism of this dependence is still unknown, but could be based on the interaction of the somatostatin analog with opioid receptors. Analgesia may be at least partially s...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90011-5
更新日期：1989-05-01 00:00:00
abstract：:The etiology of Alzheimer's dementia (AD) is unknown, but several neurotransmitters, e.g., acetylcholine, have been implicated. Recently, the group of calcium channel antagonists have been reviewed for their potential neuropsychiatric applications. These agents are capable of enhancing cholinergic tone, neurofilament/...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/0006-3223(90)90050-c
更新日期：1990-05-15 00:00:00
abstract：BACKGROUND:Increased dopaminergic activity may play a primary role in psychotic depression. Dopamine beta-hydroxylase (DbetaH) catalyses the key step in biosynthesis of the neurotransmitter noradrenaline from dopamine, and low DbetaH activity is a possible risk factor for developing psychotic depression. An exon 2 poly...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01367-1
更新日期：2002-03-01 00:00:00
abstract：:There has been a continuing interest in the possible role of the trace amine tryptamine in the etiology of neuropsychiatric disorders. We have therefore examined cerebrospinal fluid (CSF) levels of indole-3-acetic acid (IAA), the major metabolite of tryptamine, in a large group of normals and in several patient popula...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：BACKGROUND:The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females. METHODS:We described brain growth trajectories in 55 girls with TS and...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.07.032
更新日期：2020-01-15 00:00:00
abstract：:Advances in the understanding of the neurobiology of fear extinction have resulted in the development of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure treatment. We review a decade of research that has focused on the efficacy of DCS for augmenting t...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2015.09.007
更新日期：2016-08-15 00:00:00
abstract：BACKGROUND:Affective facial processing is an important component of interpersonal relationships. The neural substrate has been examined following treatment with antidepressant medication but not with psychological therapies. The present study investigated the neural correlates of implicit processing of sad facial expre...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.04.033
更新日期：2008-09-15 00:00:00
abstract：BACKGROUND:Noradrenergic function has been linked to posttraumatic stress disorder (PTSD) and might have a role in mediating sleep disturbances of the disorder. Our objective was to relate a peripheral manifestation of noradrenergic function, sympathetic nervous system activity as indexed by heart rate variability duri...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.12.018
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Sleep after learning supports memory consolidation. However, long-lasting memory effects of sleep have not yet been investigated. Postlearning sleep may be particularly involved in the long-term retention of emotional memories and could thereby contribute to the development of posttraumatic stress disorder (...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.03.061
更新日期：2006-10-01 00:00:00
abstract：:Certain investigators have asserted that the illness of anorexia nervosa is a form of hypothalamic disturbance. The relationship between 24-hr urine 3-methoxy-4-hydroxyphenylglycol (MHPG) and dexamethasone suppression tests was examined in 13 female patients with AN diagnosed by RDC. Patients showed a consistent assoc...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1981-10-01 00:00:00
abstract：BACKGROUND:Patients with autism show clinical features suggestive of abnormal processing of auditory and other sensory information. We hypothesized that low-functioning autistic subjects present abnormalities in discriminating simple auditory stimuli at sensory system preconscious stages of cortical processing. METHOD...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00295-6
更新日期：2003-09-15 00:00:00
abstract：BACKGROUND:Variations in cerebrospinal fluid (CSF) levels of the monoamine metabolites 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, and homovanillic acid have been associated with behavioral abnormalities in nonhuman primates, and with psychopathology in studies of children and adults. METHODS:We assay...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00170-x
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:The prevalence of asthma has increased in recent years and depression is common in this population. Minimal data are available on the treatment of depressed asthma patients. METHODS:Ninety adults with asthma and current major depressive disorder were randomized to receive citalopram or placebo for 12 weeks....
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2005.04.030
更新日期：2005-12-01 00:00:00
abstract：:Psychological functions that are behaviorally and neurally well specified may serve as endophenotypes for attention-deficit/hyperactivity disorder (ADHD) research. Such endophenotypes, which lie between genes and symptoms, may relate more directly to relevant genetic variability than does the clinical ADHD syndrome it...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2004.10.026
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:We recently described a preliminary association between the hypofunctional seven-repeat allele of the dopamine-4 receptor gene (DRD4) and increased maximal lifetime body mass index in women with seasonal affective disorder (SAD). In this study, we examined whether binge eating behavior mediated this putative...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.08.013
更新日期：2004-11-01 00:00:00
abstract：:To determine the degree of genetic and environmental influences on assessments of aggression and irritability in male subjects, the "Motor Aggression" subscales of the Buss-Durkee Hostility Inventory (BDHI) were mailed to 1208 male twins in the Vietnam Era Twin Registry. Data from monozygotic 182 and 118 dizygotic twi...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(96)00257-0
更新日期：1997-02-01 00:00:00
abstract：:Treatment-resistant depression (TRD) continues to represent a major challenge for treating clinicians. This report reviews the relevant literature to evaluate whether TRD can be considered a specific subtype of depression based on 1) clinical characteristics and course (behavioral phenotype), 2) neurobiological profil...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(02)01670-0
更新日期：2003-04-15 00:00:00
abstract：:Although most extinction research is conducted in animal laboratories, the study of extinction learning in human fear conditioning has gained increasing attention over the last decade. The most important findings from human fear extinction are reviewed in this article. Specifically, we review experimental investigatio...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2005.10.006
更新日期：2006-08-15 00:00:00
abstract：BACKGROUND:A polymorphism in the serotonin transporter (5-HTT) gene modulates the association between adverse early experiences and risk for major depression in adulthood. Although human imaging studies have begun to elucidate the neural circuits involved in the 5-HTT x environment risk factor, a molecular understandin...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.08.013
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Norepinephrine and dopamine mediate important aspects of alcoholism and alcohol withdrawal. Dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine. A recent study demonstrated a strong association between variance in plasma DbetaH activity and a novel polymorphism (DBH-1021C-->T) at the struc...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01427-0
更新日期：2002-12-15 00:00:00
abstract：BACKGROUND:Subjects at increased risk for psychosis experience continuous variation in the intensity of subtle psychotic experiences in response to minor stressors. It was investigated whether this psychotic reactivity in individuals at risk for psychosis is the exophenotypic expression of an underlying endophenotype c...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.biopsych.2005.02.012
更新日期：2005-07-15 00:00:00
abstract：:Serum free thyroxine (FT4), total thyroxine (TT4), and Brief Psychiatric Rating Scale (BPRS) measurements were obtained following hospital admission and at 2-week intervals during hospitalization in 80 male psychiatric inpatients with a variety of major psychotic and affective disorders. A strong correlation between t...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90148-0
更新日期：1989-01-01 00:00:00
abstract：:Depressive episodes as reversible mental states are likely to be associated with equally reversible brain states. These can be examined with a variety of functional imaging methods using repeated measures designs. Studies using such an approach are reviewed. Changes in medial frontal, and in particular, cingulate cort...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0006-3223(95)00320-7
更新日期：1996-06-15 00:00:00
abstract：BACKGROUND:Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB. METHODS:The study used prospective longitudinal data from the European IMAGEN study ado...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.01.027
更新日期：2019-06-01 00:00:00
abstract：:Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be problematic. We review the evidence from longitudinal studies that have examined this relationship and discuss the epidemiologic evidence for and against interpreting the fin...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2015.08.001
更新日期：2016-04-01 00:00:00
