当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Heart rate variability during sleep and the early development of posttraumatic stress disorder.

Heart rate variability during sleep and the early development of posttraumatic stress disorder.

Abstract：

BACKGROUND:Noradrenergic function has been linked to posttraumatic stress disorder (PTSD) and might have a role in mediating sleep disturbances of the disorder. Our objective was to relate a peripheral manifestation of noradrenergic function, sympathetic nervous system activity as indexed by heart rate variability during sleep, to the development of PTSD in subjects with recent traumatic injuries. METHODS:Subjects who had recall of life-threatening experiences were recruited from one of two regional trauma centers. Select subjects received a polysomnographic recording within 1 month of the trauma. Digitized electrocardiogram recordings were extracted from early and late rapid-eye-movement (REM) and preceding non-REM sleep periods. Autoregression was applied to R-R interval time series to calculate the ratios of low-frequency to high-frequency spectral densities (LF/HF ratios), which index sympathetic activation. Posttraumatic stress disorder status was determined at 2 months. RESULTS:There was a significant state x group interaction: LF/HF ratios were higher during the REM sleep of the nine subjects who were positive for PTSD symptoms, compared with the 10 subjects who were PTSD negative. CONCLUSIONS:Our findings are consistent with the possibility that increased noradrenergic activity during REM sleep contributes to the development of PTSD.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Mellman TA,Knorr BR,Pigeon WR,Leiter JC,Akay M

doi

10.1016/j.biopsych.2003.12.018

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

953-6

issue

9

eissn

0006-3223

issn

1873-2402

pii

S0006322304000587

journal_volume

55

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Hypothalamic-pituitary-adrenocortical function in geriatric depression: diagnostic and treatment implications.

    abstract：:Extensive work in the field has indicated a state-dependent hyperactivity of the hypothalamic-pituitary-adrenocortical (HYPAC) functions and unresponsiveness to dexamethasone suppression in at least 50% of patients suffering from endogenous depression. In this study, elderly outpatients, 60-85 years of age, suffering ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Georgotas A,Stokes PE,Krakowski M,Fanelli C,Cooper T

    更新日期：1984-05-01 00:00:00

  • Neurobiology of emotion perception II: Implications for major psychiatric disorders.

    abstract：:To date, there has been little investigation of the neurobiological basis of emotion processing abnormalities in psychiatric populations. We have previously discussed two neural systems: 1) a ventral system, including the amygdala, insula, ventral striatum, ventral anterior cingulate gyrus, and prefrontal cortex, for ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(03)00171-9

    authors： Phillips ML,Drevets WC,Rauch SL,Lane R

    更新日期：2003-09-01 00:00:00

  • Familial and sporadic subtypes of early-onset Obsessive-Compulsive disorder.

    abstract：BACKGROUND:Family studies of Obsessive-Compulsive (OCD) indicate there is substantial heterogeneity in the familiality of the disorder. This study was done to determine whether there are differences between familial and sporadic probands with early-onset OCD in obsessive-compulsive (OC) symptom categories and comorbid ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.12.022

    authors： Hanna GL,Fischer DJ,Chadha KR,Himle JA,Van Etten M

    更新日期：2005-04-15 00:00:00

  • Age and neuropsychologic function in schizophrenia: a decline in executive abilities beyond that observed in healthy volunteers.

    abstract：BACKGROUND:Kraepelin originally conceptualized schizophrenia as a degenerative brain disorder. It remains unclear whether the illness is characterized by a static encephalopathy or a deterioration of brain function, or periods of each condition. Assessments of cognitive function, as measured by neuropsychologic assessm...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(00)00240-7

    authors： Fucetola R,Seidman LJ,Kremen WS,Faraone SV,Goldstein JM,Tsuang MT

    更新日期：2000-07-15 00:00:00

  • Relationship of dysfunctional attitudes and dexamethasone response in endogenous and nonendogenous depression.

    abstract：:Taken as a whole the data presented provide support for Klein's conceptualization of etiologically distinct subtypes of depression. A basic limbic system derangement in endogenous depression is suggested by the higher incidence of DST nonsuppression. Beck's theory that all depressions result from a primary cognitive d...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Giles DE,Rush AJ

    更新日期：1982-11-01 00:00:00

  • The effects of phencyclidine on spontaneous aggressive behavior in the rat.

    abstract：:Phencyclidine induced dose-related alterations in the pattern of spontaneous aggressive behavior in pairs of rats, in which only one animal of each pair was drug-treated. At the lowest dose tested (0.25 mg/kg, sc), phencyclidine produced attacks by the drug-treated animal and a corresponding increase in submissive beh...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0304-3959(84)90863-7

    authors： Russell JW,Greenberg BD,Segal DS

    更新日期：1984-02-01 00:00:00

  • Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder.

    abstract：BACKGROUND:The goal of this study was to identify chromosomal regions likely to contain susceptibility loci for obsessive-compulsive disorder (OCD). METHODS:We conducted a genome-wide linkage scan, with average marker spacing less than 10 centimorgans (cM), in 121 subjects from 26 families ascertained through probands...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2007.01.008

    authors： Hanna GL,Veenstra-Vanderweele J,Cox NJ,Van Etten M,Fischer DJ,Himle JA,Bivens NC,Wu X,Roe CA,Hennessy KA,Dickel DE,Leventhal BL,Cook EH Jr

    更新日期：2007-10-15 00:00:00

  • Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative.

    abstract：:This overview describes the generation and development of the ideas that led to the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. It also describes the organization, process, and products of the first meeting. The CNTRICS initiative involves a series of three con...

    journal_title：Biological psychiatry

    pub_type： 共识发展会议,杂志文章

    doi：10.1016/j.biopsych.2008.03.020

    authors： Carter CS,Barch DM,Buchanan RW,Bullmore E,Krystal JH,Cohen J,Geyer M,Green M,Nuechterlein KH,Robbins T,Silverstein S,Smith EE,Strauss M,Wykes T,Heinssen R

    更新日期：2008-07-01 00:00:00

  • Anhedonia, Reduced Cocaine Reward, and Dopamine Dysfunction in a Rat Model of Posttraumatic Stress Disorder.

    abstract：BACKGROUND:Posttraumatic stress disorder (PTSD) co-occurs with substance use disorders at high rates, but the neurobiological basis of this relationship is largely unknown. PTSD and drug addiction each involve dysregulation of brain reward circuitry; therefore, the identification of pathology of the mesolimbic dopamine...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.04.024

    authors： Enman NM,Arthur K,Ward SJ,Perrine SA,Unterwald EM

    更新日期：2015-12-15 00:00:00

  • Pharmacotherapy of depressed children and adolescents: current issues and potential directions.

    abstract：:The recent deliberations by the U.S. Food and Drug Administration (FDA) regarding the relationship between antidepressants and suicidality in children have incited debates about the safety of these medications for the treatment of pediatric depression. In light of these events, this review discusses four issues pertai...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2005.10.010

    authors： Vasa RA,Carlino AR,Pine DS

    更新日期：2006-06-01 00:00:00

  • Effects of striatal ΔFosB overexpression and ketamine on social defeat stress-induced anhedonia in mice.

    abstract：BACKGROUND:Chronic social defeat stress (CSDS) produces persistent behavioral adaptations in mice. In many behavioral assays, it can be difficult to determine if these adaptations reflect core signs of depression. We designed studies to characterize the effects of CSDS on sensitivity to reward because anhedonia (reduce...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.12.014

    authors： Donahue RJ,Muschamp JW,Russo SJ,Nestler EJ,Carlezon WA Jr

    更新日期：2014-10-01 00:00:00

  • Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain.

    abstract：BACKGROUND:Chronic treatment of rats with certain selective serotonin or norepinephrine reuptake inhibitors produces significant decreases, respectively, in serotonin and norepinephrine transporter binding sites in brain. Duloxetine may be a dual serotonin/norepinephrine reuptake inhibitor, as it is only a slightly mor...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.02.029

    authors： Gould GG,Javors MA,Frazer A

    更新日期：2007-01-15 00:00:00

  • From early to late adulthood. Changes in EEG sleep of depressed patients and healthy volunteers.

    abstract：:In order to evaluate the impact of aging on EEG sleep patterns we investigated the polysomnograms of 74 patients with major depression and 51 healthy volunteers aged 18-65 years. In most of the EEG sleep parameters, age-related changes were obvious in both the depressives and the normals. In the patients, some of thes...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90355-p

    authors： Lauer CJ,Riemann D,Wiegand M,Berger M

    更新日期：1991-05-15 00:00:00

  • Psychophysiological and subjective indicators of aversive pavlovian conditioning in generalized social phobia.

    abstract：:Aversive conditioning has been proposed as an important etiologic mechanism in social phobia; however, empirical evidence is scarce and has not relied on a detailed analysis of the acquisition and extinction of the conditioned emotional response. Fourteen men sustaining generalized social phobia and 19 healthy control...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01385-9

    authors： Hermann C,Ziegler S,Birbaumer N,Flor H

    更新日期：2002-08-15 00:00:00

  • Disturbed circadian core body temperature rhythm and sleep disturbance in school refusal children and adolescents.

    abstract：:We examined the circadian rhythm of core body temperature (CBT) in 22 school refusal patients, ages between 12 and 18 years, who did not have any physical or psychiatric disorders, but had indefinite complaints, and were suspected to have a circadian rhythm disturbance. To obtain normal data for analysis, CBT in 9 hea...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0006-3223(96)00179-5

    authors： Tomoda A,Miike T,Yonamine K,Adachi K,Shiraishi S

    更新日期：1997-04-01 00:00:00

  • Associations Between Cognitive Function and Levels of Glutamatergic Metabolites and Gamma-Aminobutyric Acid in Antipsychotic-Naïve Patients With Schizophrenia or Psychosis.

    abstract：BACKGROUND:Abnormal glutamate and GABA (gamma-aminobutyric acid) levels have been found in the early phase of schizophrenia and may underlie cognitive deficits. However, the association between cognitive function and levels of glutamatergic metabolites and GABA has not been investigated in a large group of antipsychoti...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2020.06.027

    authors： Bojesen KB,Broberg BV,Fagerlund B,Jessen K,Thomas MB,Sigvard A,Tangmose K,Nielsen MØ,Andersen GS,Larsson HBW,Edden RAE,Rostrup E,Glenthøj BY

    更新日期：2021-02-01 00:00:00

  • Association between amino acid alterations and hallucinations in alcoholic patients.

    abstract：:Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma rat...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(85)90175-1

    authors： Branchey L,Branchey M,Worner TM,Zucker D,Shaw S,Lieber CS

    更新日期：1985-11-01 00:00:00

  • Development of impulse control circuitry in children of alcoholics.

    abstract：BACKGROUND:Difficulty with impulse control is heightened in children with a family history of alcohol use disorders and is a risk factor for later substance problems. Cross-sectional functional magnetic resonance imaging studies have shown altered impulse control processing in adolescents with a positive family history...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.03.005

    authors： Hardee JE,Weiland BJ,Nichols TE,Welsh RC,Soules ME,Steinberg DB,Zubieta JK,Zucker RA,Heitzeg MM

    更新日期：2014-11-01 00:00:00

  • Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder.

    abstract：BACKGROUND:The hippocampus (HC) is smaller in patients with recurrent major depressive disorder (MDD), but few longitudinal studies have examined whether volume is associated with clinically meaningful outcomes such as response to treatment. METHODS:We compared regional (head and body/tail) HC volumes in 46 patients w...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.06.027

    authors： MacQueen GM,Yucel K,Taylor VH,Macdonald K,Joffe R

    更新日期：2008-11-15 00:00:00

  • Disengagement of visual attention in infancy is associated with emerging autism in toddlerhood.

    abstract：BACKGROUND:Early emerging characteristics of visual orienting have been associated with a wide range of typical and atypical developmental outcomes. In the current study, we examined the development of visual disengagement in infants at risk for autism. METHODS:We measured the efficiency of disengaging from a central ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.11.030

    authors： Elsabbagh M,Fernandes J,Webb SJ,Dawson G,Charman T,Johnson MH,British Autism Study of Infant Siblings Team.

    更新日期：2013-08-01 00:00:00

  • Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia.

    abstract：BACKGROUND:Generalized social phobia (gSP), also known as generalized social anxiety disorder, is characterized by excessive fear of scrutiny by others and pervasive avoidance of social interactions. Pathophysiologic models of gSP implicate exaggerated reactivity of the amygdala and insula in response to social evaluat...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.10.003

    authors： Phan KL,Coccaro EF,Angstadt M,Kreger KJ,Mayberg HS,Liberzon I,Stein MB

    更新日期：2013-02-15 00:00:00

  • Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis.

    abstract：:The aberrant salience hypothesis proposes that striatal dopamine dysregulation causes misattribution of salience to irrelevant stimuli leading to psychosis. Recently, new lines of preclinical evidence on information coding by subcortical dopamine coupled with computational models of the brain's ability to predict and ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2020.03.012

    authors： Howes OD,Hird EJ,Adams RA,Corlett PR,McGuire P

    更新日期：2020-08-15 00:00:00

  • A placebo controlled trial of bupropion for smoking cessation in schizophrenia.

    abstract：BACKGROUND:Schizophrenic patients have high rates of cigarette smoking compared with the general population. We compared sustained-release (SR) bupropion with placebo for smoking cessation in patients with schizophrenic disorders. We also examined how antipsychotic class predicts smoking cessation outcomes with bupropi...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-3223(02)01339-2

    authors： George TP,Vessicchio JC,Termine A,Bregartner TA,Feingold A,Rounsaville BJ,Kosten TR

    更新日期：2002-07-01 00:00:00

  • Psychiatric symptoms and cerebrospinal fluid monoamine metabolites in primary hyperparathyroidism.

    abstract：:This prospective study included 32 patients with primary hyperparathyroidism (HPT). As compared with a healthy reference group, the patients had pronounced psychiatric symptomatology [CPRS score 17.2 +/- 9.0 (SD) versus 4.4 +/- 2.0], which was mainly affective in character. The severity of symptoms was not related to ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(88)90085-6

    authors： Joborn C,Hetta J,Rastad J,Agren H,Akerström G,Ljunghall S

    更新日期：1988-01-15 00:00:00

  • The neuropsychological profile of psychotic major depression and its relation to cortisol.

    abstract：BACKGROUND:Our study described the neuropsychological profile of psychotic major depression (PMD) compared to nonpsychotic major depression (NPMD) patients and psychiatrically healthy controls (HC). We predicted that higher cortisol levels would be associated with greater cognitive deficits. METHODS:Twenty-nine PMDs, ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2005.11.010

    authors： Gomez RG,Fleming SH,Keller J,Flores B,Kenna H,DeBattista C,Solvason B,Schatzberg AF

    更新日期：2006-09-01 00:00:00

  • Attentional Bias Predicts Increased Reward Salience and Risk Taking in Bipolar Disorder.

    abstract：BACKGROUND:There is amassing evidence that risky decision-making in bipolar disorder is related to reward-based differences in frontostriatal regions. However, the roles of early attentional and later cognitive processes remain unclear, limiting theoretical understanding and development of targeted interventions. METH...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.03.014

    authors： Mason L,Trujillo-Barreto NJ,Bentall RP,El-Deredy W

    更新日期：2016-02-15 00:00:00

  • Smaller orbital frontal cortex volumes associated with functional disability in depressed elders.

    abstract：BACKGROUND:Depression is associated with significant functional impairment. Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) and instrumental (IADL) activities of daily living. METHODS:The ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01490-7

    authors： Taylor WD,Steffens DC,McQuoid DR,Payne ME,Lee SH,Lai TJ,Krishnan KR

    更新日期：2003-01-15 00:00:00

  • Varenicline reduces alcohol self-administration in heavy-drinking smokers.

    abstract：BACKGROUND:Alcohol and tobacco dependence are highly comorbid disorders, with preclinical evidence suggesting a role for nicotinic acetylcholine receptors (nAChRs) in alcohol consumption. Varenicline, a partial nicotinic agonist with high affinity for the alpha4beta2 nAChR receptor, reduced ethanol intake in rodents. W...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2009.01.029

    authors： McKee SA,Harrison EL,O'Malley SS,Krishnan-Sarin S,Shi J,Tetrault JM,Picciotto MR,Petrakis IL,Estevez N,Balchunas E

    更新日期：2009-07-15 00:00:00

  • Reduced Brain Cannabinoid Receptor Availability in Schizophrenia.

    abstract：BACKGROUND:Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ. METHODS:Twenty five male SCZ subjects (SCZs) (18 antipsychotic treated and 7 antipsychotic free) were compared wit...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.08.021

    authors： Ranganathan M,Cortes-Briones J,Radhakrishnan R,Thurnauer H,Planeta B,Skosnik P,Gao H,Labaree D,Neumeister A,Pittman B,Surti T,Huang Y,Carson RE,D'Souza DC

    更新日期：2016-06-15 00:00:00

  • Reversal of helpless behavior in rats by putative 5-HT1A agonists.

    abstract：:This study is designed to measure effects of serotonin 1A (5-HT1A) agonists on escape deficits produced by inescapable shock in rats--a model of learned helplessness. Rats were first exposed to 60 inescapable shocks (15-sec duration, 0.8 mA, every 1 min +/- 15 sec), and 48 hr later, they were subjected to daily 15-min...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(88)90034-0

    authors： Giral P,Martin P,Soubrié P,Simon P

    更新日期：1988-02-01 00:00:00