The development of dependence to an octapeptide somatostatin analog: contribution to the study of somatostatin analgesia.

abstract：BACKGROUND:Addiction relies on persistent alterations of neuronal properties, which depends on gene regulation. Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying learning and memory. Its role in cocaine-induced neuronal and behavioral adapt...

journal_title：Biological psychiatry

authors： Salery M,Dos Santos M,Saint-Jour E,Moumné L,Pagès C,Kappès V,Parnaudeau S,Caboche J,Vanhoutte P

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:A novel, high-affinity (.7-2.0 nmol) compound that selectively activates the alpha2, alpha 3, and alpha 5 (but not alpha1) gamma-aminobutyric acid-A (GABA(A)) receptor subtypes, TPA023B (2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl) imidazo[1,2-b][1,2,4]triazin-7-yl][1,1'-biphenyl]-2-carbonitrile) was pharma...

journal_title：Biological psychiatry

authors： Van Laere K,Bormans G,Sanabria-Bohórquez SM,de Groot T,Dupont P,De Lepeleire I,de Hoon J,Mortelmans L,Hargreaves RJ,Atack JR,Burns HD

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:The reported inverse relationship between indices of central serotonin (5-HT) function and indices of impulsive aggression in human subjects suggests the possibility that enhancement of 5-HT activity will reduce impulsive aggressive behavior. Although evidence for this hypothesis is emerging, the relationshi...

journal_title：Biological psychiatry

authors： Coccaro EF,Kavoussi RJ,Hauger RL

更新日期：1997-10-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) has been reported to stimulate growth hormone (GH) release in a variety of pathological conditions, including some studies of major depression. Because of the considerable phenomenological and neuroendocrine overlap between major depression and panic disorder, we investigated the ra...

journal_title：Biological psychiatry

authors： Tancer ME,Stein MB,Uhde TW

更新日期：1990-06-01 00:00:00

abstract：:Bilateral electrodermal activity (EDA) was examined in depressed patients in remission. In Study 1, 26 unipolar and 24 bipolar patients were compared to 46 psychiatrically healthy controls. Subjects were exposed to 17 86-dB pure tones while skin conductance was recorded from both hands. In Study 2, which was conducted...

journal_title：Biological psychiatry

authors： Iacono WG,Tuason VB

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:Norepinephrine and dopamine mediate important aspects of alcoholism and alcohol withdrawal. Dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine. A recent study demonstrated a strong association between variance in plasma DbetaH activity and a novel polymorphism (DBH-1021C-->T) at the struc...

journal_title：Biological psychiatry

authors： Köhnke MD,Zabetian CP,Anderson GM,Kolb W,Gaertner I,Buchkremer G,Vonthein R,Schick S,Lutz U,Köhnke AM,Cubells JF

更新日期：2002-12-15 00:00:00

abstract：BACKGROUND:Traditionally, norepinephrine has been associated with stress responses, whereas dopamine has been associated with reward. Both of these catecholamines are found within the bed nucleus of the stria terminalis (BNST), a brain relay nucleus in the extended amygdala between cortical/limbic centers, and the hypo...

journal_title：Biological psychiatry

authors： Park J,Wheeler RA,Fontillas K,Keithley RB,Carelli RM,Wightman RM

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:Corticotropin-releasing hormone (CRH) hyperactivity in transgenic mice overexpressing CRH in the brain (CRH-OE(2122)) appears to be associated with chronic stress-like alterations, including increased CRH content in the hypothalamus, changes in hypothalamus-pituitary-adrenal axis regulation, and increased he...

journal_title：Biological psychiatry

authors： Dirks A,Groenink L,Schipholt MI,van der Gugten J,Hijzen TH,Geyer MA,Olivier B

更新日期：2002-04-01 00:00:00

abstract：:This paper reviews and correlates three separate recent findings that implicate the one-carbon cycle in neuropsychiatric disease: (i) the demonstration by kinetic studies that the Vmax of methionine adenosine transferase (MAT) is reduced in some schizophrenics and depressives and is increased in some manics, and that ...

journal_title：Biological psychiatry

authors： Smythies JR

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Plasma cortisol, beta-endorphin, corticotropin, corticotropin-releasing factor, and salivary cortisol concentrations, resting and after ingestion of 1 mg of dexamethasone, were investigated in depressed patients and controls. METHODS:Fourteen outpatients from the psychiatric department diagnosed with depres...

journal_title：Biological psychiatry

authors： Galard R,Catalán R,Castellanos JM,Gallart JM

更新日期：2002-03-15 00:00:00

abstract：:Probenecid is used to block the transport of acid monoamine metabolites from cerebrospinal fluid (CSF), on the assumption that the resultant rise in CSF concentrations of the metabolites will reflect presynaptic "turnover" of the parent monoamine. However, CSF levels of probenecid correlate with CSF levels of the meta...

journal_title：Biological psychiatry

authors： Cowdry RW,Ebert MH,van Kammen DP,Post RM,Goodwin FK

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:As observed in depressed adults, there is considerable variability in the degree and direction of hypothalamic-pituitary-adrenal (HPA) dysfunction in depressed adolescents. The variability in HPA findings may be attributed to experiential factors. METHODS:A modified version of a standard psychosocial stress...

journal_title：Biological psychiatry

authors： Rao U,Hammen C,Ortiz LR,Chen LA,Poland RE

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:Investigators have reported lack of normal asymmetry of lateralization in some schizophrenic patients, as measured postmortem and by preference and/or performance. It has been suggested that this lack of asymmetry is related to early onset of schizophrenia. The present study extends the inquiry by magnetic r...

journal_title：Biological psychiatry

authors： Maher BA,Manschreck TC,Yurgelun-Todd DA,Tsuang MT

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:The involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medications that specifically block the serotonin transporter, and there is evidence for a decrease in serotonin transporters in major depression and suicide. The midbrain dorsal raph...

journal_title：Biological psychiatry

authors： Bligh-Glover W,Kolli TN,Shapiro-Kulnane L,Dilley GE,Friedman L,Balraj E,Rajkowska G,Stockmeier CA

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:Animal and human newborn studies suggest that exposure to cocaine in utero delays glial maturation and white matter myelination. Postmortem data show that in the frontal and temporal lobes, white matter myelination continues into middle age. Recent magnetic resonance imaging (MRI) data have confirmed continu...

journal_title：Biological psychiatry

authors： Bartzokis G,Beckson M,Lu PH,Edwards N,Bridge P,Mintz J

更新日期：2002-04-15 00:00:00

abstract：:Treatment-resistant depression (TRD) continues to represent a major challenge for treating clinicians. This report reviews the relevant literature to evaluate whether TRD can be considered a specific subtype of depression based on 1) clinical characteristics and course (behavioral phenotype), 2) neurobiological profil...

journal_title：Biological psychiatry

authors： Fagiolini A,Kupfer DJ

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:Accurate recognition of facial expressions is crucial for social functioning. In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals. METHODS:Using event-relat...

journal_title：Biological psychiatry

authors： Surguladze S,Brammer MJ,Keedwell P,Giampietro V,Young AW,Travis MJ,Williams SC,Phillips ML

更新日期：2005-02-01 00:00:00

abstract：:This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad stroke...

journal_title：Biological psychiatry

authors： Tamminga CA,Nemeroff CB,Blakely RD,Brady L,Carter CS,Davis KL,Dingledine R,Gorman JM,Grigoriadis DE,Henderson DC,B Innis RB,Killen J,Laughren TP,McDonald WM,M Murphy GM Jr,Paul SM,Rudorfer MV,Sausville E,Schatzberg AF

更新日期：2002-09-15 00:00:00

abstract：:The ability of beta-adrenergic receptors to adapt to reductions in stimulation might be impaired in depressed or schizophrenic patients. To test this hypothesis 12 normal controls, 12 depressed patients resistant to tricyclic antidepressants, and 8 chronic schizophrenic patients were treated with propranolol 160 mg/da...

journal_title：Biological psychiatry

authors： Zohar J,Bannet J,Drummer D,Fisch R,Epstein RP,Belmaker RH

更新日期：1983-05-01 00:00:00

abstract：:Federal regulations governing human subjects research call for additional protections for the "mentally disabled." However, there is currently no consensus definition of mental disability or guidelines for how these research subjects should be protected. This ambiguity complicates the work of institutional review boar...

journal_title：Biological psychiatry

authors： Rosenstein DL

更新日期：1999-10-15 00:00:00

abstract：:Studies at the basic and clinical levels demonstrate that neuronal atrophy and cell death occur in response to stress and in the brains of depressed patients. Although the mechanisms have yet to be fully elucidated, progress has been made in characterizing the signal transduction cascades that control neuronal atrophy...

journal_title：Biological psychiatry

authors： Duman RS,Malberg J,Nakagawa S,D'Sa C

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:The neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures. METHODS:We used...

journal_title：Biological psychiatry

authors： Bearden CE,Thompson PM,Dalwani M,Hayashi KM,Lee AD,Nicoletti M,Trakhtenbroit M,Glahn DC,Brambilla P,Sassi RB,Mallinger AG,Frank E,Kupfer DJ,Soares JC

更新日期：2007-07-01 00:00:00

abstract：:A nutritional survey, the Pittsburgh Appetite Test (PAT), was developed to study potential changes in appetite and food preference reported by patients during a depressive episode and during antidepressant treatment. We examined a group of 50 depressed outpatients who were drug-free for 2 weeks prior to treatment with...

journal_title：Biological psychiatry

authors： Fernstrom MH,Krowinski RL,Kupfer DJ

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Functional neuroimaging studies of bipolar disorder (BD) performed in conjunction with antidepressant treatment trials generally require that patients remain on mood stabilizers to reduce the risk of inducing mania; yet, it is unknown whether the metabolic abnormalities evident in unmedicated BD depressives ...

journal_title：Biological psychiatry

authors： Mah L,Zarate CA Jr,Singh J,Duan YF,Luckenbaugh DA,Manji HK,Drevets WC

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Treatment approaches for major depressive disorder (MDD) result in approximately one third of patients achieving remission after a first treatment. Added treatment generally improves remission rates, but approximately one third of all patients fail to respond after several treatments (sequential monotherapie...

journal_title：Biological psychiatry

authors： McGrath CL,Kelley ME,Dunlop BW,Holtzheimer PE 3rd,Craighead WE,Mayberg HS

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced so...

journal_title：Biological psychiatry

authors： Swartz JR,Waller R,Bogdan R,Knodt AR,Sabhlok A,Hyde LW,Hariri AR

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Cognitive dysfunction is a hallmark feature of schizophrenia. In recent years, it has been proposed that impairments in attention, working memory and executive function may all reflect an underlying deficit in context processing. In individuals with schizophrenia, deficits in context processing have been ass...

journal_title：Biological psychiatry

authors： Delawalla Z,Csernansky JG,Barch DM

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The goal of this study was to identify chromosomal regions likely to contain susceptibility loci for obsessive-compulsive disorder (OCD). METHODS:We conducted a genome-wide linkage scan, with average marker spacing less than 10 centimorgans (cM), in 121 subjects from 26 families ascertained through probands...

journal_title：Biological psychiatry

authors： Hanna GL,Veenstra-Vanderweele J,Cox NJ,Van Etten M,Fischer DJ,Himle JA,Bivens NC,Wu X,Roe CA,Hennessy KA,Dickel DE,Leventhal BL,Cook EH Jr

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:Clinically and biologically, autism spectrum disorder (ASD) is heterogeneous. Unusual patterns of visual preference as indexed by eye tracking are hallmarks; however, whether they can be used to define an early biomarker of ASD as a whole or leveraged to define a subtype is unclear. To begin to examine this ...

journal_title：Biological psychiatry

authors： Pierce K,Marinero S,Hazin R,McKenna B,Barnes CC,Malige A

更新日期：2016-04-15 00:00:00

abstract：BACKGROUND:A novel gastric pentadecapeptide, BPC 157, has been shown to attenuate different lesions (i.e., gastrointestinal tract, liver, pancreas, somatosensory neurons). This suggests an interaction with the dopamine system. When used alone, BPC 157 does not affect gross behavior or induce stereotypy. METHODS:We fir...

journal_title：Biological psychiatry

authors： Jelovac N,Sikirić P,Rucman R,Petek M,Perović D,Konjevoda P,Marović A,Seiwerth S,Grabarević Z,Sumajstorcić J,Dodig G,Perić J

更新日期：1998-04-01 00:00:00