Abstract：
BACKGROUND:Cognitive dysfunction is a hallmark feature of schizophrenia. In recent years, it has been proposed that impairments in attention, working memory and executive function may all reflect an underlying deficit in context processing. In individuals with schizophrenia, deficits in context processing have been associated with functional impairments of the dorsolateral prefrontal cortex (DLPFC). METHODS:We used a variation of the continuous performance task, the AX-CPT, to test the hypothesis that genetic high-risk individuals (full siblings of individuals with schizophrenia) have deficits in context processing and abnormal activation of the DLPFC as compared to community controls. RESULTS:Siblings of individuals with schizophrenia made significantly more B-X errors on the AX-CPT, indicative of a deficit in context processing. They also showed task-related hyper-activation in a number of brain regions, including the DLPFC. CONCLUSIONS:Inefficient hyper-activation of the DLPFC may underlie deficits in context processing and contribute to the genetic vulnerability for developing schizophrenia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Delawalla Z,Csernansky JG,Barch DMdoi
10.1016/j.biopsych.2007.05.007subject
Has Abstractpub_date
2008-03-01 00:00:00pages
490-7issue
5eissn
0006-3223issn
1873-2402pii
S0006-3223(07)00463-5journal_volume
63pub_type
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pub_type： 临床试验,杂志文章,随机对照试验
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