Abstract：
BACKGROUND:Previous magnetic resonance imaging (MRI) studies have reported reductions in corpus callosum (CC) total area and CC regions in individuals with autism. However, studies have differed concerning the magnitude and/or region contributing to CC reductions. The present study determined the significance and magnitude of reductions in CC total and regional area measures in autism. METHOD:PubMed and PsycINFO databases were searched to identify MRI studies examining corpus callosum area in autism. Ten studies contributed data from 253 patients with autism (mean age = 14.58, SD = 6.00) and 250 healthy control subjects (mean age = 14.47, SD = 5.31). Of these 10 studies, 8 reported area measurements for corpus callosum regions (anterior, mid/body, and posterior), and 6 reported area for Witelson subdivisions. Meta-analytic procedures were used to quantify differences in total and region CC area measurements. RESULTS:Total CC area was reduced in autism and the magnitude of the reduction was medium (weighted mean d = .48, 95% confidence interval [CI] = .30-.66). All regions showed reductions in size with the magnitude of the effect decreasing caudally (anterior d = .49, mid/body d = .43, posterior d = .37). Witelson subdivision 3 (rostral body) showed the largest effect, indicating greatest reduction in the region containing premotor/supplementary motor neurons. CONCLUSIONS:Corpus callosum reductions are present in autism and support the aberrant connectivity hypothesis. Future diffusion tensor imaging studies examining specific fiber tracts connecting the hemispheres are needed to identify the cortical regions most affected by CC reductions.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Frazier TW,Hardan AYdoi
10.1016/j.biopsych.2009.07.022subject
Has Abstractpub_date
2009-11-15 00:00:00pages
935-41issue
10eissn
0006-3223issn
1873-2402pii
S0006-3223(09)00897-Xjournal_volume
66pub_type
杂志文章,meta分析abstract：BACKGROUND:A facial discrimination task was adapted to be used in an event-related potential (ERP) paradigm in order to evaluate whether young women's brain responses to affective stimuli differed from those of young men. METHODS:The stimuli used to generate a late positive component of the ERP, designated the "P450,"...
journal_title：Biological psychiatry
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pub_type： 杂志文章,评审
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journal_title：Biological psychiatry
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doi：10.1016/j.biopsych.2004.09.016
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journal_title：Biological psychiatry
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doi：10.1016/j.biopsych.2004.01.006
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journal_title：Biological psychiatry
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doi：
更新日期：1980-02-01 00:00:00
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doi：10.1016/0006-3223(95)00063-1
更新日期：1995-12-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.09.014
更新日期：2013-01-15 00:00:00
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doi：10.1016/j.biopsych.2012.03.016
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更新日期：2009-07-15 00:00:00
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更新日期：2011-05-01 00:00:00
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journal_title：Biological psychiatry
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pub_type： 杂志文章,评审
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更新日期：1998-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1993-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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更新日期：1998-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90094-3
更新日期：1991-03-15 00:00:00
abstract：BACKGROUND:Language disorder associated with schizophrenia might be due to disturbances in both automatic activation and mechanisms of controlled attention. The contribution of each process to semantic memory dysfunction has not been determined for schizophrenia, and the semantic priming paradigm is well-suited for add...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(03)00699-1
更新日期：2003-12-01 00:00:00
