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Immunity, major depression, and panic disorder comorbidity.

Abstract：

:Because recent research reports indicated clinical and biological differences in major depression with and without comorbid Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R) panic disorder, and as altered immune measures were reported in selected subgroups of depressive patients, we investigated 51 pairs of major depressive episode (MDE) subjects, and gender- and age-matched healthy controls in order to determine if T lymphocytes number and function abnormalities were associated with Panic Disorder comorbidty. We found that those MDE subjects with DSM-III-R panic disorder (PD) had greater numbers of T cells (p less than 0.05) and PHA mitogen (p less than 0.05) responses than depressive patients without PD, as well as increased phytohemagglutinin (PHA) (p less than 0.05) concanavalin A (ConA) (p less than 0.02) mitogen responses compared to their controls. These data suggest that panic disorder comorbidity significantly contributes to the variance of immunologic parameters in major depression and has to be carefully assessed within psychoimmunological studies of psychiatric patients with affective disorders.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Andreoli A,Keller SE,Rabaeus M,Zaugg L,Garrone G,Taban C

doi

10.1016/0006-3223(92)90116-h

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

896-908

issue

9

eissn

0006-3223

issn

1873-2402

pii

0006-3223(92)90116-H

journal_volume

31

pub_type

杂志文章

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