当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic function.

Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic function.

Abstract：

BACKGROUND:Our previous work has shown genetic variation in the human choline transporter gene (CHT1) to be associated with depressive symptoms and autonomic cardiac (cholinergic) dysregulation. Here, functional magnetic resonance imaging (fMRI) was used to examine the relation between a single nucleotide polymorphism (SNP) in CHT1 on regional brain reactivity relevant to autonomic (cholinergic) function. METHODS:Thirty-two participants of European ancestry (18 men, 14 women; age: 33-54 years) completed an fMRI protocol using corticolimbic reactivity and prefrontal inhibitory control paradigms. Resting cholinergic function, as measured by heart rate variability (HRV), was quantified from electrocardiogram. Subjects were genotyped for a CHT1 G/T SNP. RESULTS:GG homozygotes had greater right (R) dorsal amygdala (p < .008), bilateral anterior cingulate (p < .009), and R caudate reactivity (p < .015) than T-allele carriers. Heart rate variability was related to R frontal cortex (Brodmann Areas 6, 9, and 46), R hippocampal formation, bilateral caudate, and bilateral anterior cingulate reactivity (p's < .007). CONCLUSIONS:CHT1 variation is related to differences in a distributed corticolimbic circuitry mediating behavioral and physiologic arousal. These relations may contribute to a biological mechanism by which genetic variation in cholinergic neurotransmission affects cognition, mood, and autonomic cardiac function.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Neumann SA,Brown SM,Ferrell RE,Flory JD,Manuck SB,Hariri AR

doi

10.1016/j.biopsych.2006.03.059

subject

Has Abstract

pub_date

2006-11-15 00:00:00

pages

1155-62

issue

10

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(06)00540-3

journal_volume

60

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • An inflammatory pathway links atherosclerotic cardiovascular disease risk to neural activity evoked by the cognitive regulation of emotion.

    abstract：BACKGROUND:Cognitive reappraisal is a form of emotion regulation that alters emotional responding by changing the meaning of emotional stimuli. Reappraisal engages regions of the prefrontal cortex that support multiple functions, including visceral control functions implicated in regulating the immune system. Immune ac...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.10.012

    authors： Gianaros PJ,Marsland AL,Kuan DC,Schirda BL,Jennings JR,Sheu LK,Hariri AR,Gross JJ,Manuck SB

    更新日期：2014-05-01 00:00:00

  • Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.

    abstract：BACKGROUND:Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects indu...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.08.013

    authors： Tozzi A,de Iure A,Bagetta V,Tantucci M,Durante V,Quiroga-Varela A,Costa C,Di Filippo M,Ghiglieri V,Latagliata EC,Wegrzynowicz M,Decressac M,Giampà C,Dalley JW,Xia J,Gardoni F,Mellone M,El-Agnaf OM,Ardah MT,Puglisi-A

    更新日期：2016-03-01 00:00:00

  • Cell-type specific expression of p11 controls cocaine reward.

    abstract：BACKGROUND:The high rate of comorbidity between depression and cocaine addiction suggests shared molecular mechanisms and anatomical pathways. Limbic structures, such as the nucleus accumbens (NAc), play a crucial role in both disorders, yet how different cell types within these structures contribute to the pathogenesi...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.02.012

    authors： Arango-Lievano M,Schwarz JT,Vernov M,Wilkinson MB,Bradbury K,Feliz A,Marongiu R,Gelfand Y,Warner-Schmidt J,Nestler EJ,Greengard P,Russo SJ,Kaplitt MG

    更新日期：2014-11-15 00:00:00

  • A time-dependent history of mood disorders in a murine model of neuropathic pain.

    abstract：BACKGROUND:Chronic pain is clinically associated with the development of affective disorders. However, studies in animal models of neuropathic pain are contradictory and the relationship with mood disorders remains unclear. In this study, we aimed to characterize the affective consequences of neuropathic pain over time...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.07.017

    authors： Yalcin I,Bohren Y,Waltisperger E,Sage-Ciocca D,Yin JC,Freund-Mercier MJ,Barrot M

    更新日期：2011-11-15 00:00:00

  • Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication.

    abstract：BACKGROUND:The cAMP signaling pathway, and its downstream neurotrophic factor BDNF, are major targets of antidepressant medications. Abnormalities in this pathway have previously been reported in postmortem brain of subjects with mood disorders. This study was designed to test whether the diagnosis of a mood disorder, ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(01)01083-6

    authors： Chen B,Dowlatshahi D,MacQueen GM,Wang JF,Young LT

    更新日期：2001-08-15 00:00:00

  • A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia.

    abstract：BACKGROUND:Synapsin III plays a role in neuronal plasticity and maps to chromosome 22q12-13, a region suggested to be linked to schizophrenia. To determine if synapsin III plays a role in this disease, we searched for polymorphisms in this gene in patients with schizophrenia and controls. METHODS:The synapsin III gene...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2003.07.002

    authors： Porton B,Ferreira A,DeLisi LE,Kao HT

    更新日期：2004-01-15 00:00:00

  • Transient frontal hypoperfusion in Tc-99m hexamethylpropyleneamineoxime single photon emission computed tomography imaging during alcohol withdrawal.

    abstract：BACKGROUND:Regional brain perfusion in patients during alcohol-withdrawal has been relatively less studied with brain SPECT technique. In this study, the hypothesis that possible regional cerebral blood flow (rCBF) alterations due to alcohol withdrawal might be transitory in a homogenous group of alcoholic patients in ...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(97)00322-3

    authors： Tutus A,Kuğu N,Sofuoğlu S,Nardali M,Simşek A,Karaaslan F,Gönül AS

    更新日期：1998-06-15 00:00:00

  • A comparison of symptom provocation procedures in psychiatry and other areas of medicine: implications for their ethical use in research.

    abstract：BACKGROUND:Symptom provocation is used to study a wide variety of medical disorders. In contrast to other areas of medicine, the application of these procedures to the study of mental disease has generated significant scientific, political, and public debate. Purported differences include an overabundance of these proc...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(01)01221-5

    authors： Avila MT,Conley RR,Carpenter WT

    更新日期：2001-10-01 00:00:00

  • Similarity in saliva cortisol measures in monozygotic twins and the influence of past major depression.

    abstract：BACKGROUND:Some studies suggest that cortisol may be under genetic control. The aims of our study were to investigate the familial resemblance in morning and evening cortisol secretion as assessed by saliva cortisol and to assess the influence of history of major depression. METHODS:Women for this investigation were s...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(00)00842-8

    authors： Young EA,Aggen SH,Prescott CA,Kendler KS

    更新日期：2000-07-01 00:00:00

  • HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression.

    abstract：BACKGROUND:Recent evidence indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to increasing levels of stressful life events than do individuals who have ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2007.10.008

    authors： Gotlib IH,Joormann J,Minor KL,Hallmayer J

    更新日期：2008-05-01 00:00:00

  • Aversive stimuli drive drug seeking in a state of low dopamine tone.

    abstract：BACKGROUND:Stressors negatively impact emotional state and drive drug seeking, in part, by modulating the activity of the mesolimbic dopamine system. Unfortunately, the rapid regulation of dopamine signaling by the aversive stimuli that cause drug seeking is not well characterized. In a series of experiments, we scruti...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.09.004

    authors： Twining RC,Wheeler DS,Ebben AL,Jacobsen AJ,Robble MA,Mantsch JR,Wheeler RA

    更新日期：2015-05-15 00:00:00

  • Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indices.

    abstract：BACKGROUND:Buprenorphine (BUP) is effective in the treatment of opioid dependence when given on alternating days, probably as a result of long-lasting occupation of micro opioid receptors (microORs). This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic ...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2006.04.043

    authors： Greenwald M,Johanson CE,Bueller J,Chang Y,Moody DE,Kilbourn M,Koeppe R,Zubieta JK

    更新日期：2007-01-01 00:00:00

  • The agonist-stimulated accumulation of inositol phosphates is attenuated in neutrophils from male patients under chronic lithium therapy.

    abstract：:Neutrophils from 22 patients (11 men, 11 women) under chronic lithium therapy and from 22 age- and sex-matched healthy controls were assessed for the activity of the agonist-stimulated inositol-phospholipid second messenger-producing system. [3H]inositol-labeled cells were stimulated with the chemotactic peptide formy...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90305-6

    authors： Greil W,Steber R,van Calker D

    更新日期：1991-09-01 00:00:00

  • Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(beta-11C) DOPA and PET.

    abstract：BACKGROUND:The aim of the present study was to investigate dopamine synthesis in the brain of drug-free schizophrenic patients, not only in the striatum but also in extrastriatal areas like the prefrontal cortex, brain areas that for a long time has been in focus of interest in the pathophysiology of schizophrenia. ME...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00109-2

    authors： Lindström LH,Gefvert O,Hagberg G,Lundberg T,Bergström M,Hartvig P,Långström B

    更新日期：1999-09-01 00:00:00

  • Parenteral clomipramine challenge in depressed adolescents: mood and neuroendocrine response.

    abstract：BACKGROUND:Major depressive disorder (MDD) in the adolescent demonstrates a unique clinical profile, and pathogenic serotonergic dysregulation is hypothesized. Parenteral clomipramine (CMI) is known to distinguish adult MDD from control, but neurochallenge data are lacking in adolescent MDD. METHODS:Thirteen drug-free...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(97)00447-2

    authors： Sallee FR,Vrindavanam NS,Deas-Nesmith D,Odom AM,Carson SW,Sethuraman G

    更新日期：1998-10-01 00:00:00

  • 5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system.

    abstract：BACKGROUND:The 5HTTLPR genetic variant of the serotonin transporter (SERT), which consists of a long (SERT-l) and short (SERT-s) allele, has emerged as a major factor influencing emotional behavior and brain anatomy. The pulvinar nucleus of the thalamus projects to important limbic nuclei including the amygdala and cin...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.08.047

    authors： Young KA,Holcomb LA,Bonkale WL,Hicks PB,Yazdani U,German DC

    更新日期：2007-03-15 00:00:00

  • Further studies on the major histocompatibility complex as a genetic marker for schizophrenia.

    abstract：:Our results seem to indicate the existence of a locus in the major histocompatibity complex (MHC) region, correlated to schizophrenic illness and strictly linked to the loci HL-A and MLR. The associations found between these last loci and the disease can probably be explained by a linkage disequilibrium or a selective...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Smeraldi E,Bellodi L,Cazzullo CL

    更新日期：1976-12-01 00:00:00

  • Cognitive impairment and (CTG)n expansion in myotonic dystrophy patients.

    abstract：BACKGROUND:Myotonic dystrophy (DM) is a genetic multisystemic disease with muscular, endocrine, ocular, cardiac and cognitive impairment. The molecular basis of the disease has been identified in an unstable base triplet (CTG)n repeat located in the 3' untranslated region of the miotonin protein-kinase (MT-PK) gene on ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00016-5

    authors： Perini GI,Menegazzo E,Ermani M,Zara M,Gemma A,Ferruzza E,Gennarelli M,Angelini C

    更新日期：1999-08-01 00:00:00

  • Neuroimaging correlates of anxiety after pediatric traumatic brain injury.

    abstract：BACKGROUND:Anxiety disorders are common after traumatic brain injury (TBI). Data on the neural correlates of these conditions are lacking. This study examines the relationship between brain damage, particularly to the orbitofrontal cortex (OFC) and temporal lobe, and anxiety symptoms and disorders. METHODS:Ninety-five...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00708-x

    authors： Vasa RA,Grados M,Slomine B,Herskovits EH,Thompson RE,Salorio C,Christensen J,Wursta C,Riddle MA,Gerring JP

    更新日期：2004-02-01 00:00:00

  • Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.

    abstract：BACKGROUND:Heightened fear and anxiety are core symptoms of a variety of neuropsychiatric disorders. They are associated with structural and activity changes throughout neural circuitry that includes the ventral and medial prefrontal cortices (PFC), the amygdala, and hippocampus. Although the contributions of the media...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.03.007

    authors： Agustín-Pavón C,Braesicke K,Shiba Y,Santangelo AM,Mikheenko Y,Cockroft G,Asma F,Clarke H,Man MS,Roberts AC

    更新日期：2012-08-15 00:00:00

  • Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.

    abstract：BACKGOUND:Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential rol...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2018.01.026

    authors： Ben Hamida S,Mendonça-Netto S,Arefin TM,Nasseef MT,Boulos LJ,McNicholas M,Ehrlich AT,Clarke E,Moquin L,Gratton A,Darcq E,Harsan LA,Maldonado R,Kieffer BL

    更新日期：2018-08-01 00:00:00

  • Postnatal fluoxetine-evoked anxiety is prevented by concomitant 5-HT2A/C receptor blockade and mimicked by postnatal 5-HT2A/C receptor stimulation.

    abstract：BACKGROUND:Postnatal treatment with the selective serotonin reuptake inhibitor fluoxetine, evokes anxiety and depressive behavior in rodent models in adulthood. We examined the role of serotonin 2A (5-HT2A), serotonin 2C (5-HT2C) and serotonin 1A (5-HT1A) receptors, implicated in the development of anxiety, in the beha...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.11.005

    authors： Sarkar A,Chachra P,Vaidya VA

    更新日期：2014-12-01 00:00:00

  • Regional prefrontal gray and white matter abnormalities in bipolar disorder.

    abstract：BACKGROUND:Previous magnetic resonance imaging (MRI) studies indicate that compared with healthy volunteers, patients with bipolar disorder have structural and functional abnormalities in the prefrontal cortex. The aim of this study was to investigate differences in prefrontal subregions between bipolar patients and he...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01350-1

    authors： López-Larson MP,DelBello MP,Zimmerman ME,Schwiers ML,Strakowski SM

    更新日期：2002-07-15 00:00:00

  • Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials.

    abstract：BACKGROUND:Suvorexant is an orexin receptor antagonist for treatment of insomnia. We report results from two pivotal phase 3 trials. METHODS:Two randomized, double-blind, placebo-controlled, parallel-group, 3-month trials in nonelderly (18-64 years) and elderly (≥65 years) patients with insomnia. Suvorexant doses of 4...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.biopsych.2014.10.003

    authors： Herring WJ,Connor KM,Ivgy-May N,Snyder E,Liu K,Snavely DB,Krystal AD,Walsh JK,Benca RM,Rosenberg R,Sangal RB,Budd K,Hutzelmann J,Leibensperger H,Froman S,Lines C,Roth T,Michelson D

    更新日期：2016-01-15 00:00:00

  • Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase α to schizophrenia.

    abstract：BACKGROUND:Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPα, in the control of radial neuronal migration, cortical cytoarchitecture, and oligod...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.06.016

    authors： Takahashi N,Nielsen KS,Aleksic B,Petersen S,Ikeda M,Kushima I,Vacaresse N,Ujike H,Iwata N,Dubreuil V,Mirza N,Sakurai T,Ozaki N,Buxbaum JD,Sap J

    更新日期：2011-10-01 00:00:00

  • Connectomic disturbances in attention-deficit/hyperactivity disorder: a whole-brain tractography analysis.

    abstract：BACKGROUND:Few studies have sought to identify, in a regionally unbiased way, the precise cortical and subcortical regions that are affected by white matter abnormalities in attention-deficit/hyperactivity disorder (ADHD). This study aimed to derive a comprehensive, whole-brain characterization of connectomic disturban...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.12.013

    authors： Hong SB,Zalesky A,Fornito A,Park S,Yang YH,Park MH,Song IC,Sohn CH,Shin MS,Kim BN,Cho SC,Han DH,Cheong JH,Kim JW

    更新日期：2014-10-15 00:00:00

  • Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis.

    abstract：:The aberrant salience hypothesis proposes that striatal dopamine dysregulation causes misattribution of salience to irrelevant stimuli leading to psychosis. Recently, new lines of preclinical evidence on information coding by subcortical dopamine coupled with computational models of the brain's ability to predict and ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2020.03.012

    authors： Howes OD,Hird EJ,Adams RA,Corlett PR,McGuire P

    更新日期：2020-08-15 00:00:00

  • Evidence against linkage of schizophrenia to chromosome 5q11-q13 markers in systematically ascertained families.

    abstract：:Ten pedigrees systematically ascertained in Germany were tested for linkage to chromosome 5q11-q13. In order to replicate the previous report by Sherrington et al (1988), families with a bipolar family member were omitted from the lod score calculations, all diagnoses were based upon Research Diagnostic Criteria, and ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90008-n

    authors： Hallmayer J,Maier W,Ackenheil M,Ertl MA,Schmidt S,Minges J,Lichtermann D,Wildenauer D

    更新日期：1992-01-01 00:00:00

  • Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone.

    abstract：BACKGROUND:Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD). METHODS:In a placebo-controlled study, we examined 11 subjects with PTSD and 11 healthy...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2006.01.014

    authors： Otte C,Muhtz C,Daneshkhah S,Yassouridis A,Kiefer F,Wiedemann K,Kellner M

    更新日期：2006-10-01 00:00:00

  • Genome-wide linkage analyses of quantitative and categorical autism subphenotypes.

    abstract：BACKGROUND:The search for susceptibility genes in autism and autism spectrum disorders (ASD) has been hindered by the possible small effects of individual genes and by genetic (locus) heterogeneity. To overcome these obstacles, one method is to use autism-related subphenotypes instead of the categorical diagnosis of au...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.05.023

    authors： Liu XQ,Paterson AD,Szatmari P,Autism Genome Project Consortium.

    更新日期：2008-10-01 00:00:00