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Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone.

Abstract：

BACKGROUND:Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD). METHODS:In a placebo-controlled study, we examined 11 subjects with PTSD and 11 healthy controls between 14:00 and 21:00. After pretreatment with 3 g metyrapone to inhibit basal endogenous cortisol secretion, subjects orally received in randomized order .5 mg of the MR agonist fludrocortisone or placebo. Adrenocorticotropic hormone (ACTH), cortisol, and 11-deoxycortisol were measured every 30 min until 21:00. RESULTS:Compared to placebo, fludrocortisone led to a significant decrease of ACTH and cortisol that was similar in both groups. Subjects with PTSD had higher raw cortisol and higher normed (baseline-related) ACTH and 11-deoxycortisol values after metyrapone independent of treatment with fludrocortisone or placebo. CONCLUSIONS:While HPA responses after metyrapone seem to be stronger in PTSD compared to controls, no alterations of mineralocorticoid receptor function in PTSD were found in this study.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Otte C,Muhtz C,Daneshkhah S,Yassouridis A,Kiefer F,Wiedemann K,Kellner M

doi

10.1016/j.biopsych.2006.01.014

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

784-7

issue

7

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(06)00146-6

journal_volume

60

pub_type

杂志文章,随机对照试验

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