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No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study.

Abstract：

BACKGROUND:Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. METHODS:We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. RESULTS:The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. CONCLUSIONS:The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Kunugi H,Iijima Y,Tatsumi M,Yoshida M,Hashimoto R,Kato T,Sakamoto K,Fukunaga T,Inada T,Suzuki T,Iwata N,Ozaki N,Yamada K,Yoshikawa T

doi

10.1016/j.biopsych.2004.06.017

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

376-8

issue

5

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(04)00695-X

journal_volume

56

pub_type

杂志文章,多中心研究

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