Abstract:
:There is no definitive neural marker of suicidal thoughts and behaviors (STBs) or nonsuicidal self-injury (NSSI), and relative to adults, research in youth is more limited. This comprehensive review focuses on magnetic resonance imaging studies reporting structural and functional neural correlates of STBs and NSSI in youth to 1) elucidate shared and independent neural alternations, 2) clarify how developmental processes may interact with neural alterations to confer risk, and 3) provide recommendations based on convergence across studies. Forty-seven articles were reviewed (STBs = 27; NSSI = 20), and notably, 63% of STB articles and 45% of NSSI articles were published in the previous 3 years. Structural magnetic resonance imaging research suggests reduced volume in the ventral prefrontal and orbitofrontal cortices among youth reporting STBs, and there is reduced anterior cingulate cortex volume related to STBs and NSSI. With regard to functional alterations, blunted striatal activation may characterize STB and NSSI youth, and there is reduced frontolimbic task-based connectivity in suicide ideators and attempters. Resting-state functional connectivity findings highlight reduced positive connectivity between the default mode network and salience network in attempters and show that self-injurers exhibit frontolimbic alterations. Together, suicidal and nonsuicidal behaviors are related to top-down and bottom-up neural alterations, which may compromise approach, avoidance, and regulatory systems. Future longitudinal research with larger and well-characterized samples, especially those integrating ambulatory stress assessments, will be well positioned to identify novel targets that may improve early identification and treatment for youth with STBs and NSSI.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Auerbach RP,Pagliaccio D,Allison GO,Alqueza KL,Alonso MFdoi
10.1016/j.biopsych.2020.06.002subject
Has Abstractpub_date
2021-01-15 00:00:00pages
119-133issue
2eissn
0006-3223issn
1873-2402pii
S0006-3223(20)31671-1journal_volume
89pub_type
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journal_title:Biological psychiatry
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pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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更新日期:1995-08-01 00:00:00
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更新日期:2012-08-15 00:00:00
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pub_type: 杂志文章
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更新日期:2011-03-15 00:00:00
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更新日期:1981-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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