当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Anhedonia, Reduced Cocaine Reward, and Dopamine Dysfunction in a Rat Model of Posttraumatic Stress Disorder.

Anhedonia, Reduced Cocaine Reward, and Dopamine Dysfunction in a Rat Model of Posttraumatic Stress Disorder.

Abstract：

BACKGROUND:Posttraumatic stress disorder (PTSD) co-occurs with substance use disorders at high rates, but the neurobiological basis of this relationship is largely unknown. PTSD and drug addiction each involve dysregulation of brain reward circuitry; therefore, the identification of pathology of the mesolimbic dopamine system may aid in understanding their functional relationship. Dopamine reward dysfunction also may be relevant to the mechanisms underlying the PTSD symptoms of anhedonia and emotional numbing. METHODS:Single-prolonged stress (SPS) was used as a rat model of PTSD, and a series of behavioral and neuropharmacologic assays were applied to assess the impact of SPS on reward, cocaine intake, and components of the striatal dopamine system. RESULTS:Exposure to SPS increased anhedonia-like behaviors and decreased the rewarding properties of cocaine compared with control handling. Altered cocaine intake during extended access self-administration sessions was observed in rats exposed to SPS, further suggesting a difference in the reinforcing properties of cocaine following severe stress. SPS reduced tissue content of dopamine and its metabolites in the striatum, as well as altered striatal dopamine transporter and D2, but not D1, receptor densities. CONCLUSIONS:These results support a role for altered dopaminergic transmission in reduced reward function in PTSD. Pathology of the dopamine system and the degradation of reward processes may contribute to PTSD symptomology and have implications for co-occurring psychiatric disorders such as substance abuse or depression.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Enman NM,Arthur K,Ward SJ,Perrine SA,Unterwald EM

doi

10.1016/j.biopsych.2015.04.024

subject

Has Abstract

pub_date

2015-12-15 00:00:00

pages

871-9

issue

12

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(15)00368-6

journal_volume

78

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Elementary phenotypes in the neurobiological and genetic study of schizophrenia.

    abstract：:This review describes the strategy of using elementary phenotypes for neurobiological and genetic linkage studies of schizophrenia. The review concentrates on practical aspects of selecting the phenotype and then understanding the confounds in its measurement and interpretation. Examples from the authors' studies of d...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(99)00085-2

    authors： Adler LE,Freedman R,Ross RG,Olincy A,Waldo MC

    更新日期：1999-07-01 00:00:00

  • Toxic ictal delirium.

    abstract：:Delirium, also known as acute confusional state, is a common reversible organic psychiatric syndrome. This paper focuses on toxic delirium associated with prominent paroxysmal electroencephalogram (EEG) dysfunction occurring in nonepileptic patients. Our data derive from observations in two conditions, viz., delirium ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(89)90198-4

    authors： van Sweden B,Mellerio F

    更新日期：1989-02-15 00:00:00

  • Extinction in human fear conditioning.

    abstract：:Although most extinction research is conducted in animal laboratories, the study of extinction learning in human fear conditioning has gained increasing attention over the last decade. The most important findings from human fear extinction are reviewed in this article. Specifically, we review experimental investigatio...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2005.10.006

    authors： Hermans D,Craske MG,Mineka S,Lovibond PF

    更新日期：2006-08-15 00:00:00

  • Meta-analysis of oxidative stress in schizophrenia.

    abstract：BACKGROUND:Schizophrenia is associated with impaired antioxidant defense, including abnormal serum, plasma, and red blood cell (RBC) oxidative stress parameters. We performed a meta-analysis of these associations, considering the effect of clinical status and antipsychotic treatment after an acute exacerbation of psych...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.biopsych.2013.03.018

    authors： Flatow J,Buckley P,Miller BJ

    更新日期：2013-09-15 00:00:00

  • Prefrontal Cortex Corticotropin-Releasing Factor Receptor 1 Conveys Acute Stress-Induced Executive Dysfunction.

    abstract：BACKGROUND:The medial prefrontal cortex (mPFC) subserves complex cognition and is impaired by stress. Corticotropin-releasing factor (CRF), through CRF receptor 1 (CRFR1), constitutes a key element of the stress response. However, its contribution to the effects of stress in the mPFC remains unclear. METHODS:Mice were...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2016.03.2106

    authors： Uribe-Mariño A,Gassen NC,Wiesbeck MF,Balsevich G,Santarelli S,Solfrank B,Dournes C,Fries GR,Masana M,Labermeier C,Wang XD,Hafner K,Schmid B,Rein T,Chen A,Deussing JM,Schmidt MV

    更新日期：2016-11-15 00:00:00

  • Altered protein kinase a in brain of learned helpless rats: effects of acute and repeated stress.

    abstract：BACKGROUND:Stress-induced learned helplessness (LH) in animals serves as a model of behavioral depression and some aspects of posttraumatic stress disorder. We examined whether LH behavior is associated with alterations in protein kinase A (PKA), a critical phosphorylating enzyme, how long these alterations persist aft...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.03.018

    authors： Dwivedi Y,Mondal AC,Shukla PK,Rizavi HS,Lyons J

    更新日期：2004-07-01 00:00:00

  • Animal models of depression: parallels and correlates to severe depression in humans.

    abstract：:Drugs with antidepressant properties in patients with severe depression also have various behavioral and neurochemical effects in animals. This has given rise to numerous animal models that have been suggested to be valid for research into the neurobiology of depression and the neurochemical mechanisms of the antidepr...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(85)90156-8

    authors： Jesberger JA,Richardson JS

    更新日期：1985-07-01 00:00:00

  • The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression.

    abstract：BACKGROUND:Accumulating evidence suggests the involvement of inflammatory processes and cytokines in particular in the pathophysiology of major depression (MDD) and resistance to antidepressant treatment. Furthermore, amygdala and anterior cingulate cortex (ACC) responsiveness to emotional stimuli has been suggested as...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.11.004

    authors： Baune BT,Dannlowski U,Domschke K,Janssen DG,Jordan MA,Ohrmann P,Bauer J,Biros E,Arolt V,Kugel H,Baxter AG,Suslow T

    更新日期：2010-03-15 00:00:00

  • Interpersonal and social rhythm therapy: managing the chaos of bipolar disorder.

    abstract：:Interpersonal and social rhythm therapy is an individual psychotherapy designed specifically for the treatment for bipolar disorder. Interpersonal and social rhythm therapy grew from a chronobiological model of bipolar disorder postulating that individuals with bipolar disorder have a genetic predisposition to circadi...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(00)00969-0

    authors： Frank E,Swartz HA,Kupfer DJ

    更新日期：2000-09-15 00:00:00

  • Infections, Anti-infective Agents, and Risk of Deliberate Self-harm and Suicide in a Young Cohort: A Nationwide Study.

    abstract：BACKGROUND:Evidence links infections to mental disorders and suicidal behavior. However, knowledge is sparse regarding less severe infections, anti-infective treatment, and deliberate self-harm. Using nationwide Danish longitudinal registers, we estimated associations between infections treated with anti-infective agen...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2018.11.008

    authors： Gjervig Hansen H,Köhler-Forsberg O,Petersen L,Nordentoft M,Postolache TT,Erlangsen A,Benros ME

    更新日期：2019-05-01 00:00:00

  • Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures.

    abstract：BACKGROUND:Methylphenidate has been shown elsewhere to improve hyperactivity in about half of treated children who have pervasive developmental disorders (PDD) and significant hyperactive-inattentive symptoms. We present secondary analyses to better define the scope of effects of methylphenidate on symptoms that define...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2006.09.028

    authors： Posey DJ,Aman MG,McCracken JT,Scahill L,Tierney E,Arnold LE,Vitiello B,Chuang SZ,Davies M,Ramadan Y,Witwer AN,Swiezy NB,Cronin P,Shah B,Carroll DH,Young C,Wheeler C,McDougle CJ

    更新日期：2007-02-15 00:00:00

  • Maternal care influences hippocampal N-methyl-D-aspartate receptor function and dynamic regulation by corticosterone in adulthood.

    abstract：BACKGROUND:Variations in maternal care in the rat associate with robust differences in hippocampal development and synaptic plasticity in the offspring. Maternal care also influences pituitary-adrenal stress responses and corticosterone (CORT) regulation of hippocampal plasticity. N-methyl-D-aspartate receptors (NMDAR)...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.03.016

    authors： Bagot RC,Tse YC,Nguyen HB,Wong AS,Meaney MJ,Wong TP

    更新日期：2012-09-15 00:00:00

  • A comparison of symptom provocation procedures in psychiatry and other areas of medicine: implications for their ethical use in research.

    abstract：BACKGROUND:Symptom provocation is used to study a wide variety of medical disorders. In contrast to other areas of medicine, the application of these procedures to the study of mental disease has generated significant scientific, political, and public debate. Purported differences include an overabundance of these proc...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(01)01221-5

    authors： Avila MT,Conley RR,Carpenter WT

    更新日期：2001-10-01 00:00:00

  • Biochemical studies in early infantile autism.

    abstract：:In four series of studies on schizophrenic patients and normals we found that all the schizophrenics eliminated N, N-dimethyltryptamines in their urine while none of the normals did so. Similarly, with early infantile autism (Studies I and II) and normal controls, this separation between patiens and normals still held...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Narasimhachari N,Himwich HE

    更新日期：1975-08-01 00:00:00

  • A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress.

    abstract：BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood. Chronic stress may induce recalibrations in mitochondria leading to changes either in mitochondrial content per cell, or in mitochondrial functional capacity (i....

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2018.01.012

    authors： Picard M,Prather AA,Puterman E,Cuillerier A,Coccia M,Aschbacher K,Burelle Y,Epel ES

    更新日期：2018-07-01 00:00:00

  • Changes in neuropsychological test performance after electroconvulsive therapy.

    abstract：:A group of 231 psychiatric patients were evaluated (with the Wechsler Adult Intelligence Scale and the Halstead-Reitan Neuropsychological Test Battery) before and after electroconvulsive therapy. Improvement during the course of therapy was shown in 96% of the measures and significant improvement (p less than 0.05) oc...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Malloy FW,Small IF,Miller MJ,Milstein V,Stout JR

    更新日期：1982-01-01 00:00:00

  • Cortisol circadian rhythms during the menstrual cycle and with sleep deprivation in premenstrual dysphoric disorder and normal control subjects.

    abstract：BACKGROUND:In this study we extended previous work by examining whether disturbances in the circadian rhythms of cortisol during the menstrual cycle distinguish patients with premenstrual dysphoric disorder (PMDD) from normal control (NC) subjects. In addition, we tested the differential response to the effects of earl...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-3223(00)00876-3

    authors： Parry BL,Javeed S,Laughlin GA,Hauger R,Clopton P

    更新日期：2000-11-01 00:00:00

  • Antidepressant effects of ketamine in depressed patients.

    abstract：BACKGROUND:A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants. This is the first placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-3223(99)00230-9

    authors： Berman RM,Cappiello A,Anand A,Oren DA,Heninger GR,Charney DS,Krystal JH

    更新日期：2000-02-15 00:00:00

  • Dysfunctional glutamatergic and γ-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression.

    abstract：BACKGROUND:Depression is a complex neuropsychiatric syndrome that is often very severe and life threatening. In spite of the remarkable progress in understanding the neural biology, the etiopathophysiology of depression is still elusive. In this study, we have investigated molecular mechanisms in the prefrontal cortex ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.09.024

    authors： Veeraiah P,Noronha JM,Maitra S,Bagga P,Khandelwal N,Chakravarty S,Kumar A,Patel AB

    更新日期：2014-08-01 00:00:00

  • Antiretroviral antibodies: implications for schizophrenia, schizophrenia spectrum disorders, and bipolar disorder.

    abstract：BACKGROUND:Some retroviral antigens share structural homology within a group of related retroviruses. It is possible that antibodies directed against one virus may cross-react with antigens from a different virus in the group. METHODS:Using this principle, the human immunodeficiency virus 1 (HIV-1) Western blot assay ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00229-7

    authors： Hart DJ,Heath RG,Sautter FJ Jr,Schwartz BD,Garry RF,Choi B,Beilke MA,Hart LK

    更新日期：1999-03-15 00:00:00

  • Functional disconnection of frontal cortex and visual cortex in attention-deficit/hyperactivity disorder.

    abstract：BACKGROUND:Current pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) suggest that impaired functional connectivity within brain attention networks may contribute to the disorder. In this electroencephalographic (EEG) study, we analyzed cross-frequency amplitude correlations to investigate diffe...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.11.022

    authors： Mazaheri A,Coffey-Corina S,Mangun GR,Bekker EM,Berry AS,Corbett BA

    更新日期：2010-04-01 00:00:00

  • Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depression.

    abstract：BACKGROUND:Cerebrospinal fluid (CSF) levels of soluble amyloid precursor protein (sAPP) and its alpha-secreted form (alpha-sAPP) were investigated as a means to distinguish between individuals with mild cognitive impairment (MCI) and Alzheimer-type dementia (DAT) and those with major depressive episode (MDE) showing se...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2005.09.007

    authors： Post A,Ackl N,Rücker M,Schreiber Y,Binder EB,Ising M,Sonntag A,Holsboer F,Almeida OF

    更新日期：2006-05-01 00:00:00

  • Harnessing Gut Microbes for Mental Health: Getting From Here to There.

    abstract：:There has been an explosion of interest in the study of microorganisms inhabiting the gastrointestinal tract (gut microbiota) and their impact on host health and physiology. Accumulating data suggest that altered communication between gut microbiota and host systems could participate in disorders such as obesity, diab...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2017.08.014

    authors： Bruce-Keller AJ,Salbaum JM,Berthoud HR

    更新日期：2018-02-01 00:00:00

  • Clinical implications of pervasive manic symptoms in children.

    abstract：BACKGROUND:Prior investigations of cross-informant agreement among parents, teachers, and clinicians about externalizing and internalizing problems have not directly addressed agreement about manic symptoms. METHODS:We identified three groups from a large cohort of youths, aged 8-12 years, treated on an inpatient unit...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00068-4

    authors： Carlson GA,Youngstrom EA

    更新日期：2003-06-01 00:00:00

  • Quantitative, waking EEG research on depression.

    abstract：:Research published in the past decade that used quantitative indices to evaluate the waking EEG characteristics of depressed patients is reviewed. Methodological problems that make results of different research laboratories difficult to compare include diagnostic heterogeneity of depressed groups, lack of inclusion of...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0006-3223(90)90591-o

    authors： Pollock VE,Schneider LS

    更新日期：1990-04-01 00:00:00

  • Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative.

    abstract：:This overview describes the generation and development of the ideas that led to the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. It also describes the organization, process, and products of the first meeting. The CNTRICS initiative involves a series of three con...

    journal_title：Biological psychiatry

    pub_type： 共识发展会议,杂志文章

    doi：10.1016/j.biopsych.2008.03.020

    authors： Carter CS,Barch DM,Buchanan RW,Bullmore E,Krystal JH,Cohen J,Geyer M,Green M,Nuechterlein KH,Robbins T,Silverstein S,Smith EE,Strauss M,Wykes T,Heinssen R

    更新日期：2008-07-01 00:00:00

  • Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density.

    abstract：BACKGROUND:Abnormalities of cortical neuronal organization and reductions in neuronal somal size have been reported in schizophrenia. The purpose of this investigation was to assess patterns of neuronal and glial distribution in the anterior cingulate cortex (ACC) in major depressive disorder (MDD), schizophrenia, bipo...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00114-8

    authors： Chana G,Landau S,Beasley C,Everall IP,Cotter D

    更新日期：2003-06-15 00:00:00

  • Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders.

    abstract：BACKGROUND:Gastrointestinal (GI) symptoms and abnormalities in stool consistency are frequently reported by parents of children with autism spectrum disorders (ASD). The purpose of this study was to 1) describe dietary intake of a cohort of children with ASD compared with normative data and 2) determine whether GI symp...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2006.07.013

    authors： Levy SE,Souders MC,Ittenbach RF,Giarelli E,Mulberg AE,Pinto-Martin JA

    更新日期：2007-02-15 00:00:00

  • Delayed circadian rhythm in adults with attention-deficit/hyperactivity disorder and chronic sleep-onset insomnia.

    abstract：BACKGROUND:Previous studies suggest circadian rhythm disturbances in children with attention-deficit/hyperactivity disorder (ADHD) and sleep-onset insomnia (SOI). We investigate here sleep and rhythms in activity and melatonin in adults with ADHD. METHODS:Sleep logs and actigraphy data were collected during 1 week in ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.12.032

    authors： Van Veen MM,Kooij JJ,Boonstra AM,Gordijn MC,Van Someren EJ

    更新日期：2010-06-01 00:00:00

  • Effects of dietary selenium on mood in healthy men living in a metabolic research unit.

    abstract：:Eleven healthy men were confined in a metabolic research unit for 120 days in a double-blind study of the effects of dietary selenium on mood as assessed by the Profile of Mood States-Bipolar Form. At an intake of 2800 kcal/day, the diet of conventional foods provided 80 micrograms/day of selenium for the first 21 day...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0006-3223(95)00085-2

    authors： Hawkes WC,Hornbostel L

    更新日期：1996-01-15 00:00:00