Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative.

abstract：:A decreased secretion of arginine vasopressin (AVP) has been implicated in depression. In order to further investigate this hypothesis, we studied the plasma level of the specific peptidergic carrier of AVP, vasopressin neurophysin (hNpI), in 26 depressed inpatients and 16 matched normal controls. On the other hand, A...

journal_title：Biological psychiatry

authors： Laruelle M,Seghers A,Goffinet S,Bouchez S,Legros JJ

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Language delay is a hallmark feature of autism spectrum disorders (ASD). The identification of word boundaries in continuous speech is a critical first step in language acquisition that can be accomplished via statistical learning and reliance on speech cues. Importantly, early word segmentation skills have ...

journal_title：Biological psychiatry

authors： Scott-Van Zeeland AA,McNealy K,Wang AT,Sigman M,Bookheimer SY,Dapretto M

更新日期：2010-08-15 00:00:00

abstract：BACKGROUND:Accurate recognition of facial expressions is crucial for social functioning. In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals. METHODS:Using event-relat...

journal_title：Biological psychiatry

authors： Surguladze S,Brammer MJ,Keedwell P,Giampietro V,Young AW,Travis MJ,Williams SC,Phillips ML

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Excessive glutamatergic neurotransmission may contribute to the pathophysiology of major depressive disorder (MDD). Recent evidence suggests that riluzole and other agents that target glutamate neurotransmission may show antidepressant activity. METHODS:Ten patients with treatment-resistant depression had r...

journal_title：Biological psychiatry

authors： Sanacora G,Kendell SF,Levin Y,Simen AA,Fenton LR,Coric V,Krystal JH

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Recent studies raise questions on the relationship between adolescent fears and risk for major depression. METHODS:An epidemiologic sample of 776 young people received psychiatric assessments in 1983, 1985-1986, and 1992. Prospective associations were examined between fears in adolescence and future episode...

journal_title：Biological psychiatry

authors： Pine DS,Cohen P,Brook J

更新日期：2001-11-01 00:00:00

abstract：:Drugs with antidepressant properties in patients with severe depression also have various behavioral and neurochemical effects in animals. This has given rise to numerous animal models that have been suggested to be valid for research into the neurobiology of depression and the neurochemical mechanisms of the antidepr...

journal_title：Biological psychiatry

authors： Jesberger JA,Richardson JS

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Considering that platelets have been established to be good peripheral markers for the study of catecholaminergic neurons, we have applied an assay to measure the uptake of (3H)-dopamine (DA) into platelet storage granules (PSG). Recently, we reported that Tourette's syndrome (TS) patients (pts) show decreas...

journal_title：Biological psychiatry

authors： Rabey JM,Amir I,Treves TA,Oberman Z,Korczyn AD

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Recent evidence from clinical studies and animal models of traumatic brain injury (TBI) suggest that neuronal and glial loss might progress after the initial insult in selectively vulnerable regions of the brain such as the hippocampus. There is also evidence that hippocampal dysfunction plays a role in the ...

journal_title：Biological psychiatry

authors： Jorge RE,Acion L,Starkstein SE,Magnotta V

更新日期：2007-08-15 00:00:00

abstract：BACKGROUND:The GRIN1 gene plays a fundamental role in many brain functions, and its involvement in the pathogenesis of the schizophrenia has been widely investigated. Non-synonymous polymorphisms have not been identified in the coding regions. To investigate the potential role of GRIN1 in the susceptibility to schizoph...

journal_title：Biological psychiatry

authors： Begni S,Moraschi S,Bignotti S,Fumagalli F,Rillosi L,Perez J,Gennarelli M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas, has been implicated in mood disorders such as major depression and anxiety. Within the 5-HT1A receptor gene, a powerful dual repressor element (DRE) is regulated ...

journal_title：Biological psychiatry

authors： Hadjighassem MR,Austin MC,Szewczyk B,Daigle M,Stockmeier CA,Albert PR

更新日期：2009-08-01 00:00:00

abstract：:Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH) and somatostatin (SRIF) were measured in 77 female inpatients with moderate to extreme dementia and in 17 elderly female controls. Both multi-infarct (MID) and Alzheimer-type (SDAT) demented patients had eq...

journal_title：Biological psychiatry

authors： Banki CM,Karmacsi L,Bissette G,Nemeroff CB

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Postmortem brain studies have shown that HDAC1-a lysine deacetylase with broad activity against histones and nonhistone proteins-is frequently expressed at increased levels in prefrontal cortex (PFC) of subjects diagnosed with schizophrenia and related disease. However, it remains unclear whether upregulated...

journal_title：Biological psychiatry

authors： Jakovcevski M,Bharadwaj R,Straubhaar J,Gao G,Gavin DP,Jakovcevski I,Mitchell AC,Akbarian S

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Animal and human newborn studies suggest that exposure to cocaine in utero delays glial maturation and white matter myelination. Postmortem data show that in the frontal and temporal lobes, white matter myelination continues into middle age. Recent magnetic resonance imaging (MRI) data have confirmed continu...

journal_title：Biological psychiatry

authors： Bartzokis G,Beckson M,Lu PH,Edwards N,Bridge P,Mintz J

更新日期：2002-04-15 00:00:00

abstract：:The present study investigated the impact of the cholinesterase inhibitor tetrahydroaminoacridine (THA; tacrine) on sleep in healthy subjects. According to the reciprocal interaction model of non-rapid eye movement (NREM) and REM sleep regulation, which postulates a primary role in cholinergic neurotransmission for th...

journal_title：Biological psychiatry

authors： Riemann D,Lis S,Fritsch-Montero R,Meier T,Krieger S,Hohagen F,Berger M

更新日期：1996-05-01 00:00:00

abstract：:The etiology of Alzheimer's dementia (AD) is unknown, but several neurotransmitters, e.g., acetylcholine, have been implicated. Recently, the group of calcium channel antagonists have been reviewed for their potential neuropsychiatric applications. These agents are capable of enhancing cholinergic tone, neurofilament/...

journal_title：Biological psychiatry

authors： Tollefson GD

更新日期：1990-05-15 00:00:00

abstract：BACKGROUND:Brain imaging and behavioral studies suggest an inverse relationship between dopamine (DA) D2/D3 receptors and vulnerability to cocaine abuse, although most research has used males. For example, male monkeys that become dominant in a social group have significant elevations in D2/D3 receptor availability and...

journal_title：Biological psychiatry

authors： Nader MA,Nader SH,Czoty PW,Riddick NV,Gage HD,Gould RW,Blaylock BL,Kaplan JR,Garg PK,Davies HM,Morton D,Garg S,Reboussin BA

更新日期：2012-09-01 00:00:00

abstract：:Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma rat...

journal_title：Biological psychiatry

authors： Branchey L,Branchey M,Worner TM,Zucker D,Shaw S,Lieber CS

更新日期：1985-11-01 00:00:00

abstract：:The neuroimaging community has witnessed a paradigm shift in biomarker discovery from using traditional univariate brain mapping approaches to multivariate predictive models, allowing the field to move toward a translational neuroscience era. Regression-based multivariate models (hereafter "predictive modeling") provi...

journal_title：Biological psychiatry

authors： Sui J,Jiang R,Bustillo J,Calhoun V

更新日期：2020-12-01 00:00:00

abstract：:Advances in the understanding of the neurobiology of fear extinction have resulted in the development of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure treatment. We review a decade of research that has focused on the efficacy of DCS for augmenting t...

journal_title：Biological psychiatry

authors： Otto MW,Kredlow MA,Smits JAJ,Hofmann SG,Tolin DF,de Kleine RA,van Minnen A,Evins AE,Pollack MH

更新日期：2016-08-15 00:00:00

abstract：:The possibility of characterizing subgroups of depressive disorders by biological markers was studied by means of the dexamethasone suppression test (DST), the 24-hr urinary free cortisol (UFC), the growth hormone response to the insulin tolerance test (ITT), and polygraphic sleep recordings. Forty-five hospitalized p...

journal_title：Biological psychiatry

authors： Berger M,Doerr P,Lund R,Bronisch T,von Zerssen D

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Difficulty with impulse control is heightened in children with a family history of alcohol use disorders and is a risk factor for later substance problems. Cross-sectional functional magnetic resonance imaging studies have shown altered impulse control processing in adolescents with a positive family history...

journal_title：Biological psychiatry

authors： Hardee JE,Weiland BJ,Nichols TE,Welsh RC,Soules ME,Steinberg DB,Zubieta JK,Zucker RA,Heitzeg MM

更新日期：2014-11-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) measures of dynorphin A were compared in three groups. Alzheimer patients (n = 9), elderly depressives (n = 9), and age-matched normal controls (n = 9). The Alzheimer patients revealed a 40% decrease in CSF dynorphin compared with controls (36 +/- 15 versus 60 +/- 21 pg/ml, p less than 0.05)....

journal_title：Biological psychiatry

authors： Sunderland T,Berrettini WH,Molchan SE,Lawlor BA,Martinez RA,Vitiello B,Tariot PN,Cohen RM

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Quantitative genetic analysis of basic mouse behaviors is a powerful tool to identify novel genetic phenotypes contributing to neurobehavioral disorders. Here, we analyzed genetic contributions to single-trial, long-term social and nonsocial recognition and subsequently studied the functional impact of an id...

journal_title：Biological psychiatry

authors： Bruining H,Matsui A,Oguro-Ando A,Kahn RS,Van't Spijker HM,Akkermans G,Stiedl O,van Engeland H,Koopmans B,van Lith HA,Oppelaar H,Tieland L,Nonkes LJ,Yagi T,Kaneko R,Burbach JP,Yamamoto N,Kas MJ

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medications that specifically block the serotonin transporter, and there is evidence for a decrease in serotonin transporters in major depression and suicide. The midbrain dorsal raph...

journal_title：Biological psychiatry

authors： Bligh-Glover W,Kolli TN,Shapiro-Kulnane L,Dilley GE,Friedman L,Balraj E,Rajkowska G,Stockmeier CA

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:Pregnancy and the postpartum period are a time of increased risk for women to develop mood disorders. As such, the reproductive safety data on antidepressant use during pregnancy have rapidly expanded over the last decade; however, there is relatively sparse information on maternal/fetal exchange of these me...

journal_title：Biological psychiatry

authors： Hostetter A,Ritchie JC,Stowe ZN

更新日期：2000-11-15 00:00:00

abstract：BACKGROUND:Patients with autism have been often reported to have a smaller corpus callosum (CC) than control subjects. METHODS:We conducted a meta-analysis of the literature, analyzed the CC in 694 subjects of the Autism Brain Imaging Data Exchange project, and performed computer simulations to study the effect of dif...

journal_title：Biological psychiatry

authors： Lefebvre A,Beggiato A,Bourgeron T,Toro R

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:In this study we extended previous work by examining whether disturbances in the circadian rhythms of cortisol during the menstrual cycle distinguish patients with premenstrual dysphoric disorder (PMDD) from normal control (NC) subjects. In addition, we tested the differential response to the effects of earl...

journal_title：Biological psychiatry

authors： Parry BL,Javeed S,Laughlin GA,Hauger R,Clopton P

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Previous investigations suggest that maltreated children evidence alterations of chemical mediators of stress and adverse brain development. Previous anatomical magnetic resonance imaging (MRI) brain studies have not controlled for socioeconomic status. METHODS:In this study, 28 psychotropic naïve children ...

journal_title：Biological psychiatry

authors： De Bellis MD,Keshavan MS,Shifflett H,Iyengar S,Beers SR,Hall J,Moritz G

更新日期：2002-12-01 00:00:00

abstract：:Neutrophils from 22 patients (11 men, 11 women) under chronic lithium therapy and from 22 age- and sex-matched healthy controls were assessed for the activity of the agonist-stimulated inositol-phospholipid second messenger-producing system. [3H]inositol-labeled cells were stimulated with the chemotactic peptide formy...

journal_title：Biological psychiatry

authors： Greil W,Steber R,van Calker D

更新日期：1991-09-01 00:00:00

abstract：:Tricyclic antidepressants are thought to act primarily via effects on adrenergic neurotransmitters. Recent research supports the concept that a major function of the central adrenergic system is the modulation of cerebral fluid dynamics. Based on this concept, studies in the rat were conducted to assess the effects of...

journal_title：Biological psychiatry

authors： Preskorn SH,Hartman BK

更新日期：1979-04-01 00:00:00