Abstract：
BACKGROUND:Excessive glutamatergic neurotransmission may contribute to the pathophysiology of major depressive disorder (MDD). Recent evidence suggests that riluzole and other agents that target glutamate neurotransmission may show antidepressant activity. METHODS:Ten patients with treatment-resistant depression had riluzole added to their ongoing medication regimen for 6 weeks, followed by an optional 6-week continuation phase. Depression and anxiety severity were assessed using the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS). Linear mixed models were used to test for a linear trend in HDRS and HARS scores across time with treatment. RESULTS:Subjects' HDRS and HARS scores declined significantly following the initiation of riluzole augmentation therapy. The effect of riluzole was significant at the end of the first week of treatment and persisted for the 12-week duration of the study. CONCLUSIONS:These data suggest that riluzole augmentation produces antidepressant and anxiolytic effects in patients with treatment-resistant depression.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Sanacora G,Kendell SF,Levin Y,Simen AA,Fenton LR,Coric V,Krystal JHdoi
10.1016/j.biopsych.2006.08.037subject
Has Abstractpub_date
2007-03-15 00:00:00pages
822-5issue
6eissn
0006-3223issn
1873-2402pii
S0006-3223(06)01080-8journal_volume
61pub_type
临床试验,杂志文章abstract：BACKGROUND:Most depressed adults exhibit dysregulation of the hypothalamic-pituitary-adrenal axis, including cortisol hyperreactivity to psychosocial challenge. In contrast, remarkably little is known about hypothalamic-pituitary-adrenal axis activity in response to psychosocial challenge among at-risk children and ado...
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