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Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study.

Abstract：

BACKGROUND:Previous reports of ventricular and hippocampal volumes in patients with bipolar disorder (BP) have been inconsistent in their findings. One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests that psychotic (PBP) and nonpsychotic (NPBP) forms of BP are two subtypes that might differ in pathophysiology. METHODS:We investigated ventricular and hippocampal volumes in 38 adults with clearly defined PBP (n = 23) and NPBP subtypes, compared with 33 persons with schizophrenia (SZ) and 44 healthy community control subjects (HC). Ventricular and hippocampal volumes were reliably measured on high-resolution anatomic magnetic resonance imaging scans. We used a multivariate analysis of covariance to compare volumes across groups, covarying for total brain volume. Potential effects of BP illness features were explored, contrasting PBP and NPBP. RESULTS:For ventricular but not hippocampal regions, we found significant volume difference in PBP but not NPBP compared with HC (p < .005). We also observed nonsignificantly smaller left hippocampal volumes in PBP versus HC. Schizophrenic subjects had significantly larger ventricular and smaller left hippocampal volumes than HC. CONCLUSIONS:These results suggest that PBP but not NPBP is associated with increased ventricle volumes and a trend toward smaller left hippocampal volumes, as observed in SZ.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Strasser HC,Lilyestrom J,Ashby ER,Honeycutt NA,Schretlen DJ,Pulver AE,Hopkins RO,Depaulo JR,Potash JB,Schweizer B,Yates KO,Kurian E,Barta PE,Pearlson GD

doi

10.1016/j.biopsych.2004.12.009

subject

Has Abstract

pub_date

2005-03-15 00:00:00

pages

633-9

issue

6

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(04)01313-7

journal_volume

57

pub_type

杂志文章

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