Abstract：
:The functional role of cholecystokinin in the central nervous system is unknown. The tetra peptide CCK-4 was previously observed to induce panic attacks in a majority of normal volunteers and patients with panic disorder. Furthermore, it had been demonstrated that pretreatment with 10-50 mg of L-365,260, a selective CCKB antagonist, blocked CCK-4 induced panic in patients with panic disorder. Therefore, the present multicenter, placebo-controlled, double-blind trial was designed to investigate the efficacy of L-365,260, a CCKB antagonist, in patients with panic disorder with or without agoraphobia. Following a 1-week, single-blind placebo period, 88 patients were randomized to double-blind treatment in which they received either L-365,260, 30 mg qid, or placebo for 6 weeks. At the dose tested, there were no clinically significant differences between L-365,260 and placebo in global improvement ratings, Hamilton anxiety rating scale scores, panic attack frequency, panic attack intensity, or disability measures. The possible reasons for lack of effect with L-365,260 are discussed.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Kramer MS,Cutler NR,Ballenger JC,Patterson WM,Mendels J,Chenault A,Shrivastava R,Matzura-Wolfe D,Lines C,Reines Sdoi
10.1016/0006-3223(94)00190-Esubject
Has Abstractpub_date
1995-04-01 00:00:00pages
462-6issue
7eissn
0006-3223issn
1873-2402pii
0006-3223(94)00190-Ejournal_volume
37pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：BACKGROUND:Our study described the neuropsychological profile of psychotic major depression (PMD) compared to nonpsychotic major depression (NPMD) patients and psychiatrically healthy controls (HC). We predicted that higher cortisol levels would be associated with greater cognitive deficits. METHODS:Twenty-nine PMDs, ...
journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(97)00008-5
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abstract：:The relationship between plasma kynurenine (KYN) concentration and anxiety and depression in psychiatric patients was examined. KYN has been reported as a probable endogenous anxiogen in animal models of anxiety. Thirty patients with affective states were studied. The Hamilton Anxiety Scale (HAM-A), Hamilton Depressio...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0006-3223(94)91189-4
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2018-05-15 00:00:00
abstract：BACKGROUND:Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging. METHODS:Twenty elderly patients meeting DSM-IV criteria for m...
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doi：10.1016/j.biopsych.2011.07.017
更新日期：2011-11-15 00:00:00
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journal_title：Biological psychiatry
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更新日期：1998-11-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.biopsych.2004.11.021
更新日期：2005-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00030-x
更新日期：1999-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.12.028
更新日期：2011-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2015.05.020
更新日期：2016-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.biopsych.2005.04.022
更新日期：2005-09-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.09.004
更新日期：2013-02-15 00:00:00
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journal_title：Biological psychiatry
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doi：10.1016/s0006-3223(99)00109-2
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journal_title：Biological psychiatry
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doi：10.1016/j.biopsych.2010.02.008
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journal_title：Biological psychiatry
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doi：10.1016/j.biopsych.2006.08.019
更新日期：2007-04-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1997-08-15 00:00:00
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journal_title：Biological psychiatry
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更新日期：2010-06-01 00:00:00
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journal_title：Biological psychiatry
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更新日期：2020-09-10 00:00:00
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journal_title：Biological psychiatry
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更新日期：1993-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.05.023
更新日期：2008-10-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.12.025
更新日期：2017-07-15 00:00:00
abstract：:IgA antibody levels in serum were examined in two groups of schizophrenic patients. All were diagnosed according to DSM-III-R criteria. One group of 36 males and 12 females were compared to historical controls. The other group consisted of 13 males off drugs for at least 3 months; these were compared with age- and sex...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)00176-4
更新日期：1995-03-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0006-3223(00)00241-9
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:QTc interval prolongation can occur as a result of treatment with both conventional and novel antipsychotic medications and is of clinical concern because of its association with the potentially fatal ventricular arrhythmia, torsade de pointes. METHODS:One case is described in which a patient with schizophr...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01333-6
更新日期：2002-02-01 00:00:00
