当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > The neuropsychological profile of psychotic major depression and its relation to cortisol.

The neuropsychological profile of psychotic major depression and its relation to cortisol.

Abstract：

BACKGROUND:Our study described the neuropsychological profile of psychotic major depression (PMD) compared to nonpsychotic major depression (NPMD) patients and psychiatrically healthy controls (HC). We predicted that higher cortisol levels would be associated with greater cognitive deficits. METHODS:Twenty-nine PMDs, 24 NPMDs, and 26 HCs were recruited at Stanford University Medical Center. Psychiatric ratings, cortisol levels from 1800-0900 hours, and neuropsychological test data were obtained. RESULTS:PMDs had more severe cognitive impairments compared with NPMDs and HCs with the exception of simple verbal attention. PMDs had elevated mean cortisol levels from 1800 to 0100 hours which were significantly correlated with poorer verbal memory and psychomotor speed performance. Cortisol slopes from 1800 to 0100 hours were also significantly correlated with verbal memory and working memory. CONCLUSIONS:While PMDs' ability to attend passively to information appears intact, they have more difficulty processing, manipulating, and encoding new information. Elevated cortisol levels, as seen in PMD patients, are associated with poorer cognitive performance especially related to verbal memory for lists of words and working memory.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Gomez RG,Fleming SH,Keller J,Flores B,Kenna H,DeBattista C,Solvason B,Schatzberg AF

doi

10.1016/j.biopsych.2005.11.010

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

472-8

issue

5

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(05)01422-8

journal_volume

60

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Familial and sporadic subtypes of early-onset Obsessive-Compulsive disorder.

    abstract：BACKGROUND:Family studies of Obsessive-Compulsive (OCD) indicate there is substantial heterogeneity in the familiality of the disorder. This study was done to determine whether there are differences between familial and sporadic probands with early-onset OCD in obsessive-compulsive (OC) symptom categories and comorbid ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.12.022

    authors： Hanna GL,Fischer DJ,Chadha KR,Himle JA,Van Etten M

    更新日期：2005-04-15 00:00:00

  • Effect of phenytoin on mood and declarative memory during prescription corticosteroid therapy.

    abstract：BACKGROUND:In humans and animals, corticosteroid excess is associated with impairment in declarative memory and changes in hippocampal structure. In animals, phenytoin pretreatment blocks the effects of stress on memory and hippocampal histology, although no studies have examined the use of phenytoin to prevent cortico...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2004.11.021

    authors： Brown ES,Stuard G,Liggin JD,Hukovic N,Frol A,Dhanani N,Khan DA,Jeffress J,Larkin GL,McEwen BS,Rosenblatt R,Mageto Y,Hanczyc M,Cullum CM

    更新日期：2005-03-01 00:00:00

  • Increased temporal lobe glucose use in chronic schizophrenic patients.

    abstract：:Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with 18F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(89)90263-1

    authors： DeLisi LE,Buchsbaum MS,Holcomb HH,Langston KC,King AC,Kessler R,Pickar D,Carpenter WT Jr,Morihisa JM,Margolin R

    更新日期：1989-04-01 00:00:00

  • Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories.

    abstract：BACKGROUND:A method that promotes the retrieval of lost long-term memories has not been well established. Histamine in the central nervous system is implicated in learning and memory, and treatment with antihistamines impairs learning and memory. Because histamine H3 receptor inverse agonists upregulate histamine relea...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2018.11.009

    authors： Nomura H,Mizuta H,Norimoto H,Masuda F,Miura Y,Kubo A,Kojima H,Ashizuka A,Matsukawa N,Baraki Z,Hitora-Imamura N,Nakayama D,Ishikawa T,Okada M,Orita K,Saito R,Yamauchi N,Sano Y,Kusuhara H,Minami M,Takahashi H,Ikeg

    更新日期：2019-08-01 00:00:00

  • Differential effect of haloperidol and clozapine on plasma homovanillic acid in elderly schizophrenic patients with or without tardive dyskinesia.

    abstract：BACKGROUND:Plasma homovanillic acid (HVA) changes in response to a challenge of several days with haloperidol have been found to be predictive of the therapeutic response to haloperidol over a longer period of treatment. METHODS:Twenty-six elderly women who gave informed consent were divided into two groups, with or w...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(97)00257-6

    authors： Andia I,Zumarraga M,Zabalo MJ,Bulbena A,Davila R

    更新日期：1998-01-01 00:00:00

  • The role of glutamate and gamma-aminobutyric acid in fear extinction: clinical implications for exposure therapy.

    abstract：:Although much is now known about the neural basis of fear acquisition, the mechanisms of fear inhibition or suppression remain largely obscure. Fear inhibition is studied in the laboratory through the use of an extinction procedure, in which an animal (typically a rat) is exposed to nonreinforced presentations of a co...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(02)01507-x

    authors： Davis M,Myers KM

    更新日期：2002-11-15 00:00:00

  • A family study of unsocialized aggressive boys.

    abstract：:The psychiatric histories of relatives of 17 boys admitted to an inpatient unit with "unsocialized aggressive" behavior and of 19 boys admitted with other problems were investigated by means of structured interviews. The interviews were rated blind and diagnoses made on the respondents and relatives described in the f...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Stewart MA,Leone L

    更新日期：1978-02-01 00:00:00

  • The effect of distraction on acute schizophrenics' visual tracking.

    abstract：:To examine the nature of impaired smooth pursuit eye movement (SPEM) in schizophrenia, 16 hospitalized schizophrenics in the acute phase and 16 hospitalized nonpsychotic patients were studied. The experiment consisted of five 30-sec visual tracking phases: (i) base line (no distraction); (ii) auditory-visual distracti...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Pass HL,Salzman LF,Klorman R,Kaskey GB,Klein RH

    更新日期：1978-10-01 00:00:00

  • Cognitive behavioral therapy guided self-help and orlistat for the treatment of binge eating disorder: a randomized, double-blind, placebo-controlled trial.

    abstract：BACKGROUND:Cognitive behavioral therapy (CBT) has efficacy for binge eating disorder (BED) but not obesity. No controlled studies have tested whether adding obesity medication to CBT facilitates weight loss. We performed a randomized, placebo-controlled study of orlistat administered with guided self-help CBT (CBTgsh)....

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2005.03.001

    authors： Grilo CM,Masheb RM,Salant SL

    更新日期：2005-05-15 00:00:00

  • Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.

    abstract：BACKGOUND:Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential rol...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2018.01.026

    authors： Ben Hamida S,Mendonça-Netto S,Arefin TM,Nasseef MT,Boulos LJ,McNicholas M,Ehrlich AT,Clarke E,Moquin L,Gratton A,Darcq E,Harsan LA,Maldonado R,Kieffer BL

    更新日期：2018-08-01 00:00:00

  • Elevated gamma-aminobutyric acid levels in chronic schizophrenia.

    abstract：BACKGROUND:Despite widely replicated abnormalities of gamma-aminobutyric acid (GABA) neurons in schizophrenia postmortem, few studies have measured tissue GABA levels in vivo. We used proton magnetic resonance spectroscopy to measure tissue GABA levels in participants with schizophrenia and healthy control subjects in ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.05.016

    authors： Ongür D,Prescot AP,McCarthy J,Cohen BM,Renshaw PF

    更新日期：2010-10-01 00:00:00

  • Paradoxical growth-hormone responses to thyrotropin-releasing hormone in panic disorder.

    abstract：:Thyrotropin-releasing hormone (TRH) has been reported to stimulate growth hormone (GH) release in a variety of pathological conditions, including some studies of major depression. Because of the considerable phenomenological and neuroendocrine overlap between major depression and panic disorder, we investigated the ra...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(90)90420-7

    authors： Tancer ME,Stein MB,Uhde TW

    更新日期：1990-06-01 00:00:00

  • Enhanced orbitofrontal cortex function and lack of attentional bias to cocaine cues in recreational stimulant users.

    abstract：BACKGROUND:Although cocaine is known to be a highly addictive drug, there appears to be a select subset of individuals who are able to use the substance recreationally without developing dependence. These individuals do not report experiencing feelings of craving for cocaine, an important distinction from dependent use...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.05.019

    authors： Smith DG,Simon Jones P,Bullmore ET,Robbins TW,Ersche KD

    更新日期：2014-01-15 00:00:00

  • Correlations of glutathione peroxidase activity with memory impairment in adults with Down syndrome.

    abstract：BACKGROUND:Down syndrome (DS) is a genetic disorder (trisomy 21 in 96% of cases), associated with an excess of a key enzyme involved with free radical metabolism (FRM), superoxide dismutase-1 (SOD-1), that is encoded by a gene on chromosome 21. Consequently, SOD-1 activity is elevated in DS, which also occurs in condit...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00026-8

    authors： Brugge K,Nichols S,Saitoh T,Trauner D

    更新日期：1999-12-15 00:00:00

  • Lack of effect of laboratory-provoked anxiety on plasma homovanillic acid concentration in normal subjects.

    abstract：:The present study was undertaken to investigate if acute anxiety can affect plasma concentrations of homovanillic acid (pHVA). Since elevated pHVA levels have been associated with severity of schizophrenic symptoms, the results of this study will help determine if the pHVA elevations are directly related to psychosis ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(95)00390-8

    authors： Zemishlany Z,Davidson M

    更新日期：1996-08-15 00:00:00

  • Neonatal lesions of the ventral hippocampal formation alter GABA-A receptor subunit mRNA expression in adult rat frontal pole.

    abstract：BACKGROUND:Gamma-aminobutyric acid (GABA)-ergic function is altered in schizophrenia. Of particular interest is the altered central nervous system expression of GABA-A receptor subunits, as changes in subunit expression account for recognized differences in mammalian brain function making them inviting targets for nove...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.09.017

    authors： Mitchell CP,Grayson DR,Goldman MB

    更新日期：2005-01-01 00:00:00

  • Plasma dexamethasone concentrations and the dexamethasone suppression test.

    abstract：:Altered bioavailability or altered pharmacokinetics of dexamethasone (dex) may contribute to a positive Dexamethasone Suppression Test (DST) in psychiatric patients. We measured plasma dex and plasma cortisol concentrations in 32 patients with primary major depressive disorder (MDD), 14 patients with other psychiatric...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(90)90646-j

    authors： Ritchie JC,Belkin BM,Krishnan KR,Nemeroff CB,Carroll BJ

    更新日期：1990-01-15 00:00:00

  • Pharmacological characterization of tardive akathisia.

    abstract：:A patient with tardive neuroleptic-induced akathisia was investigated with multiple pharmacological challenges. It was noted that the patient responded positively to benztropine, bromocriptine, and propranolol, and negatively to physostigmine, and showed little or no response to discontinuation of neuroleptics and cha...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0006-3223(90)90515-4

    authors： Sachdev P,Chee KY

    更新日期：1990-11-01 00:00:00

  • A fenfluramine-activated FDG-PET study of borderline personality disorder.

    abstract：BACKGROUND:Impulsive aggression in patients with personality disorders is associated with diminished levels of cerebrospinal fluid (CSF) 5-HIAA, blunted neuroendocrine responses to serotonergic agonists, and decreased glucose utilization in the prefrontal cortex. We tested the hypothesis that impulsive aggression in bo...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(99)00202-4

    authors： Soloff PH,Meltzer CC,Greer PJ,Constantine D,Kelly TM

    更新日期：2000-03-15 00:00:00

  • Circadian patterns of cortisol, prolactin, and growth hormonal secretion during bingeing and vomiting in normal weight bulimic patients.

    abstract：:Women who are of normal weight and have bulimia nervosa exhibit multiple neuroendocrine disturbances. We hypothesized that bingeing and vomiting behavior could be contributory because food consumption in healthy volunteers increases plasma cortisol and prolactin secretion and suppresses growth hormone secretion. Thus,...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90068-w

    authors： Weltzin TE,McConaha C,McKee M,Hsu LK,Perel J,Kaye WH

    更新日期：1991-07-01 00:00:00

  • Calcium channel blockade interacts with a neuroleptic to attenuate the conditioning of amphetamine's behavioral effects in the rat.

    abstract：:Conditioned responses to drug-related cues appear to be related to the maintenance of stimulant addiction. These conditioned responses are not blocked by treatments that block the direct effects of stimulants and may contribute to the high rate of relapse of addicts. Rats administered (+)-amphetamine in a specific env...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90159-w

    authors： DiLullo SL,Martin-Iverson MT

    更新日期：1992-06-01 00:00:00

  • G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis.

    abstract：:Association of the G72/G30 locus with schizophrenia and bipolar disorder has now been reported in several studies. The G72/G30 locus may be one of several that account for the evidence of linkage that spans a broad region of chromosome 13q. However, the story of G72/G30 is complex. Our meta-analysis of published assoc...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.biopsych.2006.01.019

    authors： Detera-Wadleigh SD,McMahon FJ

    更新日期：2006-07-15 00:00:00

  • Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention.

    abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder characterized by deficits in attention, increased motor impulsivity, and hyperactivity. Preliminary work in mice and humans has suggested the X-linked gene STS (which encodes the enzyme steroid sulfatase) as a mediator o...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.01.001

    authors： Davies W,Humby T,Kong W,Otter T,Burgoyne PS,Wilkinson LS

    更新日期：2009-08-15 00:00:00

  • Resting regional cerebral perfusion in recent posttraumatic stress disorder.

    abstract：BACKGROUND:Brain imaging research in posttraumatic stress disorder has been largely performed on patients with chronic disease, often heavily medicated, with current or past alcohol and substance abuse. Additionally, virtually only activation brain imaging paradigms have been done in posttraumatic stress disorder, wher...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00525-0

    authors： Bonne O,Gilboa A,Louzoun Y,Brandes D,Yona I,Lester H,Barkai G,Freedman N,Chisin R,Shalev AY

    更新日期：2003-11-15 00:00:00

  • Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study.

    abstract：BACKGROUND:Previous investigations suggest that maltreated children evidence alterations of chemical mediators of stress and adverse brain development. Previous anatomical magnetic resonance imaging (MRI) brain studies have not controlled for socioeconomic status. METHODS:In this study, 28 psychotropic naïve children ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01459-2

    authors： De Bellis MD,Keshavan MS,Shifflett H,Iyengar S,Beers SR,Hall J,Moritz G

    更新日期：2002-12-01 00:00:00

  • Social isolation in animal models of relevance to neuropsychiatric disorders.

    abstract：:Animal models of social isolation have been suggested to be relevant to several neuropsychiatric disorders; however, social isolation is usually not purely an alteration of social environment, as it often involves such factors as decreased complexity of the environment, loss of tactile stimulation, and increased metab...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(95)00546-3

    authors： Kim JW,Kirkpatrick B

    更新日期：1996-11-01 00:00:00

  • Impaired prepulse inhibition of acoustic startle in schizophrenia.

    abstract：BACKGROUND:Schizophrenics show deficits in sensorimotor gating, as measured by prepulse inhibition of acoustic startle (PPI). The goal of this investigation is to further characterize PPI and habituation deficits in schizophrenia, and to examine whether differing subgroups of schizophrenics would show comparable PPI de...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00148-1

    authors： Parwani A,Duncan EJ,Bartlett E,Madonick SH,Efferen TR,Rajan R,Sanfilipo M,Chappell PB,Chakravorty S,Gonzenbach S,Ko GN,Rotrosen JP

    更新日期：2000-04-01 00:00:00

  • Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development.

    abstract：BACKGROUND:Quantitative genetic analysis of basic mouse behaviors is a powerful tool to identify novel genetic phenotypes contributing to neurobehavioral disorders. Here, we analyzed genetic contributions to single-trial, long-term social and nonsocial recognition and subsequently studied the functional impact of an id...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.01.017

    authors： Bruining H,Matsui A,Oguro-Ando A,Kahn RS,Van't Spijker HM,Akkermans G,Stiedl O,van Engeland H,Koopmans B,van Lith HA,Oppelaar H,Tieland L,Nonkes LJ,Yagi T,Kaneko R,Burbach JP,Yamamoto N,Kas MJ

    更新日期：2015-10-01 00:00:00

  • Unimodal and crossmodal reactivity in autism: presence of auditory evoked responses and effect of the repetition of auditory stimuli.

    abstract：:Using auditory evoked responses, this work compares the reactivities to unimodal and crossmodal stimuli and the main neurocognitive functions most often disturbed in autism. With the aim of testing the hypothesis that the deficit in the ability to form crossmodal associations in autism is linked to a cognitive abnorma...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90338-z

    authors： Martineau J,Roux S,Garreau B,Adrien JL,Lelord G

    更新日期：1992-06-15 00:00:00

  • Sister chromatid exchanges and cell cycle kinetics in Alzheimer's disease.

    abstract：:Six female outpatients with Alzheimer's disease (AD) along with four female controls of a similar age range were analyzed for sister chromatid exchangers (SCEs), cell cycle kinetics, and sensitivity to mutagens, in lymphocyte cultures. The mean level of SCEs for the AD patients was 11.40 SCEs/metaphase, while that for...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Fischman HK,Reisberg B,Albu P,Ferris SH,Rainer JD

    更新日期：1984-03-01 00:00:00