Abstract:
BACKGROUND:Schizophrenics show deficits in sensorimotor gating, as measured by prepulse inhibition of acoustic startle (PPI). The goal of this investigation is to further characterize PPI and habituation deficits in schizophrenia, and to examine whether differing subgroups of schizophrenics would show comparable PPI deficits. METHODS:PPI was measured in 24 male schizophrenic subjects (9 acutely decompensated inpatients and 15 stable outpatients) and in 20 age-matched normal control subjects. Schizophrenic subjects were rated for positive and negative symptoms at the time of testing. RESULTS:Schizophrenic subjects showed deficits in prepulse inhibition and habituation as compared to normal subjects. Similar latency facilitation was produced by the prepulse in both groups. Acutely decompensated inpatients and stable outpatients did not differ in percent PPI. PPI did not correlate with severity of positive or negative symptoms. CONCLUSIONS:These results suggest that schizophrenic subjects have impaired central inhibitory mechanisms as measured by PPI, and support the hypothesis that periods of relative clinical remission are not accompanied by normalization of sensorimotor gating.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Parwani A,Duncan EJ,Bartlett E,Madonick SH,Efferen TR,Rajan R,Sanfilipo M,Chappell PB,Chakravorty S,Gonzenbach S,Ko GN,Rotrosen JPdoi
10.1016/s0006-3223(99)00148-1subject
Has Abstractpub_date
2000-04-01 00:00:00pages
662-9issue
7eissn
0006-3223issn
1873-2402pii
S0006-3223(99)00148-1journal_volume
47pub_type
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journal_title:Biological psychiatry
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Biological psychiatry
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doi:
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
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journal_title:Biological psychiatry
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更新日期:2010-12-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2002-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2003-09-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
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