Reversal of helpless behavior in rats by putative 5-HT1A agonists.

abstract：:The male bias in autism spectrum disorder incidence is among the most extreme of all neuropsychiatric disorders, yet the origins of the sex difference remain obscure. Developmentally, males are exposed to high levels of testosterone and its byproduct, estradiol. Together these steroids modify the course of brain devel...

journal_title：Biological psychiatry

authors： McCarthy MM,Wright CL

更新日期：2017-03-01 00:00:00

abstract：:Previous studies suggest that catecholaminergic overactivity and structural brain damage may contribute to the pathogenesis of tardive dyskinesia (TD). Although dopaminergic (DA) mechanisms, specifically postsynaptic receptor supersensitivity, have been extensively studied, equally plausible noradrenergic (NE) changes...

journal_title：Biological psychiatry

authors： Kaufmann CA,Jeste DV,Shelton RC,Linnoila M,Kafka MS,Wyatt RJ

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Memories associated with drugs of abuse, such as methamphetamine (METH), increase relapse vulnerability to substance use disorder by triggering craving. The nucleus accumbens (NAc) is essential to these drug-associated memories, but underlying mechanisms are poorly understood. Posttranslational chromatin mod...

journal_title：Biological psychiatry

authors： Aguilar-Valles A,Vaissière T,Griggs EM,Mikaelsson MA,Takács IF,Young EJ,Rumbaugh G,Miller CA

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Cognitive behavioral therapy (CBT) has efficacy for binge eating disorder (BED) but not obesity. No controlled studies have tested whether adding obesity medication to CBT facilitates weight loss. We performed a randomized, placebo-controlled study of orlistat administered with guided self-help CBT (CBTgsh)....

journal_title：Biological psychiatry

authors： Grilo CM,Masheb RM,Salant SL

更新日期：2005-05-15 00:00:00

abstract：BACKGROUND:The lateral nucleus of the amygdala (LA) is a crucial part of the neural circuitry underlying the formation and storage of memories established through fear conditioning. To investigate corticotropin-releasing factor (CRF) contributions to fear memory in LA, the present experiments tested the effects of intr...

journal_title：Biological psychiatry

authors： Isogawa K,Bush DE,LeDoux JE

更新日期：2013-02-15 00:00:00

abstract：BACKGROUND:Brainstem auditory evoked potentials (BAEP) reflect the activation of brainstem nuclei in the first milliseconds after presentation of an auditory stimulus. These electrophysiological correlates of neural processing are highly automatic and not influenced by cognitive factors or task demands; however, data f...

journal_title：Biological psychiatry

authors： Baas JM,Milstein J,Donlevy M,Grillon C

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females. METHODS:We described brain growth trajectories in 55 girls with TS and...

journal_title：Biological psychiatry

authors： O'Donoghue S,Green T,Ross JL,Hallmayer J,Lin X,Jo B,Huffman LC,Hong DS,Reiss AL

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:Variations in cerebrospinal fluid (CSF) levels of the monoamine metabolites 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, and homovanillic acid have been associated with behavioral abnormalities in nonhuman primates, and with psychopathology in studies of children and adults. METHODS:We assay...

journal_title：Biological psychiatry

authors： Constantino JN,Murphy DL,Morris JA

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Conflicting findings have emerged from studies examining the impact of depression on death and readmission following a coronary event, possibly reflecting differences in the measurement of "depression" and the onset of depression in relation to the coronary event. The aim of this study was to examine the rel...

journal_title：Biological psychiatry

authors： Parker GB,Hilton TM,Walsh WF,Owen CA,Heruc GA,Olley A,Brotchie H,Hadzi-Pavlovic D

更新日期：2008-10-15 00:00:00

abstract：BACKGROUND:The N-methyl-D-aspartate receptor antagonist, ketamine, produces a clinical syndrome of thought disorder, perceptual distortion, and cognitive impairment. METHODS:We have administered ketamine to healthy volunteers to characterize the formal thought disorder and specific memory dysfunction associated with k...

journal_title：Biological psychiatry

authors： Adler CM,Goldberg TE,Malhotra AK,Pickar D,Breier A

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Studies in elderly patients demonstrate antipsychotic efficacy and favorable safety profiles for olanzapine. We report results from two placebo-controlled, double-blind studies of olanzapine for treatment of dopamimetic drug-induced psychosis in patients with Parkinson's disease (PD). METHODS:Patients were ...

journal_title：Biological psychiatry

authors： Breier A,Sutton VK,Feldman PD,Kadam DL,Ferchland I,Wright P,Friedman JH

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Fragile X syndrome (FXS) is the most common known heritable cause of intellectual disability. Prior studies in FXS have observed a plateau in cognitive and adaptive behavioral development in early adolescence, suggesting that brain development in FXS may diverge from typical development during this period. ...

journal_title：Biological psychiatry

authors： Bray S,Hirt M,Jo B,Hall SS,Lightbody AA,Walter E,Chen K,Patnaik S,Reiss AL

更新日期：2011-11-01 00:00:00

abstract：:It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal events. It is clear that the interaction between genetic predisposition and early life environment...

journal_title：Biological psychiatry

authors： Codagnone MG,Spichak S,O'Mahony SM,O'Leary OF,Clarke G,Stanton C,Dinan TG,Cryan JF

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Relations between stress hormones and antisocial behavior are understudied. METHODS:A subsample (n = 335) of at-risk males recruited in first grade for a longitudinal study were recruited at approximately 16 years of age for a laboratory study, including two psychological challenges: describing their worst ...

journal_title：Biological psychiatry

authors： McBurnett K,Raine A,Stouthamer-Loeber M,Loeber R,Kumar AM,Kumar M,Lahey BB

更新日期：2005-05-15 00:00:00

abstract：:We investigated the computerized electroencephalography (cEEG) in a group of 85 normal adolescents. The spatial frequency of the cEEG was analyzed using various multivariate statistical techniques. The factor analyses revealed three factors that accounted for most of the variability in the data and that could be inter...

journal_title：Biological psychiatry

authors： Volkow ND,Gomez-Mont F,Inamdar S,Lamella M,Prichep L,John R

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Depression and stress promote obesity. This study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on obesity-related metabolic responses to high-fat meals. METHODS:This double-blind, randomized, crossover study included serial assessments of resting energy expenditur...

journal_title：Biological psychiatry

authors： Kiecolt-Glaser JK,Habash DL,Fagundes CP,Andridge R,Peng J,Malarkey WB,Belury MA

更新日期：2015-04-01 00:00:00

abstract：:Methysergide a clinically used blocker of serotonin receptors, was given for 48 hr to 11 normal adults, at a dose of 8 mg per 24 hr. Total REM sleep time was decreased, although total sleep time was unchanged. Stage 4 decreased and stage 3 increased, while total slow wave sleep remained constant. There was a tendency ...

journal_title：Biological psychiatry

authors： Mendelson WB,Reichman J,Othmer E

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder with a genetic risk component, yet identification of high-confidence risk genes has been challenging. In recent years, risk gene discovery in other complex psychiatric disorders has been achieved by studying rare de novo (DN) cod...

journal_title：Biological psychiatry

authors： Cappi C,Oliphant ME,Péter Z,Zai G,Conceição do Rosário M,Sullivan CAW,Gupta AR,Hoffman EJ,Virdee M,Olfson E,Abdallah SB,Willsey AJ,Shavitt RG,Miguel EC,Kennedy JL,Richter MA,Fernandez TV

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:We conducted a meta-analysis to re-evaluate the role of the dopamine D4 receptor gene 48-base-pair- repeat (DRD4) polymorphism in mood disorders. METHODS:DRD4 allele frequencies were compared between 917 patients with unipolar (UP) or bipolar affective disorder (BP) and 1164 control subjects from 12 samples...

journal_title：Biological psychiatry

authors： López León S,Croes EA,Sayed-Tabatabaei FA,Claes S,Van Broeckhoven C,van Duijn CM

更新日期：2005-05-01 00:00:00

abstract：:Twenty-three inpatients who met DSM-III criteria for schizophrenia were selected for cerebrospinal fluid (CSF) neurochemical study of tardive dyskinesia (TD). Ten inpatients had tardive dyskinesia, and the remaining 13 patients without TD served as controls. There were no intergroup differences in sex, age, duration o...

journal_title：Biological psychiatry

authors： Lu RB,Ko HC,Lin WL,Lin YT,Ho SL

更新日期：1989-03-15 00:00:00

abstract：:Mood disorders are the leading causes of morbidity and mortality in children and adolescence. As a result, many adolescents are treated with psychopharmacologic agents such as antidepressants and mood stabilizers. To date, research into the safety and efficacy of these medications has lagged behind clinical practice. ...

journal_title：Biological psychiatry

authors： Emslie GJ,Mayes TL

更新日期：2001-06-15 00:00:00

abstract：BACKGROUND:Recent studies have suggested that there may be a preferential decrease of "nonpyramidal" neurons (NPs) in several corticolimbic regions of schizophrenic (SZ) brain. The current study was undertaken to determine whether a change in the density of pyramidal neurons (PNs) and NPs might be present in the hippoc...

journal_title：Biological psychiatry

authors： Benes FM,Kwok EW,Vincent SL,Todtenkopf MS

更新日期：1998-07-15 00:00:00

abstract：BACKGROUND:The aim of this study was to extend our previous work on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) in major depression to patients with schizophrenia. METHODS:Thirty-five inpatients with schizophrenia were randomly assigned to either right prefrontal rTMS or sham treatm...

journal_title：Biological psychiatry

authors： Klein E,Kolsky Y,Puyerovsky M,Koren D,Chistyakov A,Feinsod M

更新日期：1999-11-15 00:00:00

abstract：BACKGROUND:Anxiety disorders are common after traumatic brain injury (TBI). Data on the neural correlates of these conditions are lacking. This study examines the relationship between brain damage, particularly to the orbitofrontal cortex (OFC) and temporal lobe, and anxiety symptoms and disorders. METHODS:Ninety-five...

journal_title：Biological psychiatry

authors： Vasa RA,Grados M,Slomine B,Herskovits EH,Thompson RE,Salorio C,Christensen J,Wursta C,Riddle MA,Gerring JP

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Recent evidence from clinical studies and animal models of traumatic brain injury (TBI) suggest that neuronal and glial loss might progress after the initial insult in selectively vulnerable regions of the brain such as the hippocampus. There is also evidence that hippocampal dysfunction plays a role in the ...

journal_title：Biological psychiatry

authors： Jorge RE,Acion L,Starkstein SE,Magnotta V

更新日期：2007-08-15 00:00:00

abstract：:Direct current potentials measured on the scalp suprajacent to the midline prefrontal cortex appear to monitor the metabolic activity, via CO2 production, of this portion of the cerebrum. Changes in the frontal potential 90 min after oral administration of 2.0 g L-tryptophan and of 50 mg cortisol were studied in group...

journal_title：Biological psychiatry

authors： Cowen MA

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:The dexamethasone/corticotropin releasing hormone (Dex/CRH) test has been proposed as a potential tool for identifying endophenotypes relevant to mood disorders. Several studies have shown abnormal cortisol reactivity in phenotypically healthy adults without psychiatric disorders as a function of exposure to...

journal_title：Biological psychiatry

authors： Carpenter LL,Tyrka AR,Ross NS,Khoury L,Anderson GM,Price LH

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Recent evidence indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to increasing levels of stressful life events than do individuals who have ...

journal_title：Biological psychiatry

authors： Gotlib IH,Joormann J,Minor KL,Hallmayer J

更新日期：2008-05-01 00:00:00

abstract：:The long-term test-retest reliability of event-related potentials (ERP) measures was examined in a group of 44 controls and 71 chronic alcoholics, retested after an average of 14 months. Correlational analyses revealed moderately significant test-retest correlations for visual and auditory target N1, N2, and P3 amplit...

journal_title：Biological psychiatry

authors： Sinha R,Bernardy N,Parsons OA

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:K-complexes (KCs) are evoked delta frequency electroencephalogram (EEG) responses during sleep that occur when large numbers of healthy cortical cells burst fire in a synchronized manner. The KC amplitude and incidence are sensitive measures of normal healthy brain aging. Given the known neurodegenerative co...

journal_title：Biological psychiatry

authors： Colrain IM,Crowley KE,Nicholas CL,Padilla M,Baker FC

更新日期：2009-07-15 00:00:00