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Aberrant frontal lobe maturation in adolescents with fragile X syndrome is related to delayed cognitive maturation.

Abstract：

BACKGROUND:Fragile X syndrome (FXS) is the most common known heritable cause of intellectual disability. Prior studies in FXS have observed a plateau in cognitive and adaptive behavioral development in early adolescence, suggesting that brain development in FXS may diverge from typical development during this period. METHODS:In this study, we examined adolescent brain development using structural magnetic resonance imaging data acquired from 59 individuals with FXS and 83 typically developing control subjects aged 9 to 22, a subset of whom were followed up longitudinally (1-5 years; typically developing: 17, FXS: 19). Regional volumes were modeled to obtain estimates of age-related change. RESULTS:We found that while structures such as the caudate showed consistent volume differences from control subjects across adolescence, prefrontal cortex (PFC) gyri showed significantly aberrant maturation. Furthermore, we found that PFC-related measures of cognitive functioning followed a similarly aberrant developmental trajectory in FXS. CONCLUSIONS:Our findings suggest that aberrant maturation of the PFC during adolescence may contribute to persistent or increasing intellectual deficits in FXS.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Bray S,Hirt M,Jo B,Hall SS,Lightbody AA,Walter E,Chen K,Patnaik S,Reiss AL

doi

10.1016/j.biopsych.2011.05.038

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

852-8

issue

9

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(11)00636-6

journal_volume

70

pub_type

杂志文章

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