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Neonatal intrahippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats.

Abstract：

BACKGROUND:Among the diverse animal models proposed for schizophrenia, the neonatal ventral hippocampal lesion (NVHL) is one of the most widely used. However, its construct validity can be questioned because there is no evidence of a lesion present in schizophrenia. Other approaches that have tried to capture environmental influences on development include diverse models of maternal infection. METHODS:As the early postnatal days in rodents are equivalent to the third trimester of human pregnancy in terms of brain development, we decided to test whether a neonatal immune challenge with an injection of the bacterial endotoxin lipopolysaccharide (LPS) into the ventral hippocampus caused deficits in interneuron function similar to those reported for the NVHL. RESULTS:Neonatal LPS injection caused a persistent elevation in cytokines in several brain regions, deficits in prepulse inhibition of the acoustic startle response, and a loss of the periadolescent maturation in the response of prefrontal cortical fast-spiking interneurons to dopamine. CONCLUSIONS:The same phenotypes elicited by a NVHL can be obtained with an intrahippocampal immune challenge, suggesting that perinatal environmental factors can affect adult prefrontal interneuron maturation during adolescence.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Feleder C,Tseng KY,Calhoon GG,O'Donnell P

doi

10.1016/j.biopsych.2009.09.028

subject

Has Abstract

pub_date

2010-02-15 00:00:00

pages

386-92

issue

4

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(09)01158-5

journal_volume

67

pub_type

杂志文章

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