Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation.

Abstract:

BACKGROUND:A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) allele showed stronger amygdala activation than long (l) carriers. However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers. METHODS:Functional MRI was used to assess amygdala activation during the presentation of a fixation cross or affectively aversive or neutral visual stimuli in 29 healthy men. RESULTS:Amygdala activation was increased in s carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions. CONCLUSIONS:This finding suggests that s carriers show stronger amygdala reactivity to stimuli and contexts that are relatively uncertain, which we propose are stressful.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Heinz A,Smolka MN,Braus DF,Wrase J,Beck A,Flor H,Mann K,Schumann G,Büchel C,Hariri AR,Weinberger DR

doi

10.1016/j.biopsych.2006.08.019

subject

Has Abstract

pub_date

2007-04-15 00:00:00

pages

1011-4

issue

8

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(06)01068-7

journal_volume

61

pub_type

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