Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation.

Abstract:

BACKGROUND:A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) allele showed stronger amygdala activation than long (l) carriers. However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers. METHODS:Functional MRI was used to assess amygdala activation during the presentation of a fixation cross or affectively aversive or neutral visual stimuli in 29 healthy men. RESULTS:Amygdala activation was increased in s carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions. CONCLUSIONS:This finding suggests that s carriers show stronger amygdala reactivity to stimuli and contexts that are relatively uncertain, which we propose are stressful.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Heinz A,Smolka MN,Braus DF,Wrase J,Beck A,Flor H,Mann K,Schumann G,Büchel C,Hariri AR,Weinberger DR

doi

10.1016/j.biopsych.2006.08.019

subject

Has Abstract

pub_date

2007-04-15 00:00:00

pages

1011-4

issue

8

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(06)01068-7

journal_volume

61

pub_type

杂志文章
  • Infections, Anti-infective Agents, and Risk of Deliberate Self-harm and Suicide in a Young Cohort: A Nationwide Study.

    abstract:BACKGROUND:Evidence links infections to mental disorders and suicidal behavior. However, knowledge is sparse regarding less severe infections, anti-infective treatment, and deliberate self-harm. Using nationwide Danish longitudinal registers, we estimated associations between infections treated with anti-infective agen...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2018.11.008

    authors: Gjervig Hansen H,Köhler-Forsberg O,Petersen L,Nordentoft M,Postolache TT,Erlangsen A,Benros ME

    更新日期:2019-05-01 00:00:00

  • Effects of changes in carbon dioxide tension in abnormally prolonged contingent negative variation (CNV).

    abstract::The effects of changes in pCO2 in the development and resolution of normal (return to base line within 2 sec after S2) and abnormal (return to base line in more than 2 sec after S2) CNVs were studied. Decreased pCO2 produced by hyperventilation induced a significant reduction in the duration of the post-imperative neg...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Dubrovsky B,Garcia-Rill E,Simkus R,Dongier M

    更新日期:1976-10-01 00:00:00

  • Impaired declarative memory consolidation during sleep in patients with primary insomnia: Influence of sleep architecture and nocturnal cortisol release.

    abstract:BACKGROUND:A central cognitive function of sleep is to consolidate newly acquired memories for long-term storage. Here, we investigated whether the overnight consolidation of declarative memory in patients with chronic sleep disturbances is impaired, owing to less slow wave sleep (SWS) and an increased cortisol release...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2006.03.051

    authors: Backhaus J,Junghanns K,Born J,Hohaus K,Faasch F,Hohagen F

    更新日期:2006-12-15 00:00:00

  • Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons.

    abstract:BACKGROUND:Our previous studies indicated that N-methyl-D-aspartate receptor (NMDAR) deletion from a subset of corticolimbic interneurons in the mouse brain during early postnatal development is sufficient to trigger several behavioral and pathophysiological features resembling the symptoms of human schizophrenia. Inte...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2012.12.004

    authors: Jiang Z,Rompala GR,Zhang S,Cowell RM,Nakazawa K

    更新日期:2013-05-15 00:00:00

  • A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide pol

    abstract:BACKGROUND:The DBH gene regulates plasma dopamine beta-hydroxylase activity (pDbetaH). Two single nucleotide polymorphisms (SNPs), -1021C-->T (rs1611115; SNP1) and +1603C-->T (rs6271; SNP3), independently influence pDbetaH. Another SNP, commonly known as DBH Taq1A (rs2519152; SNP2) is associated with attention-deficit/...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2006.02.017

    authors: Tang Y,Buxbaum SG,Waldman I,Anderson GM,Zabetian CP,Köhnke MD,Cubells JF

    更新日期:2006-11-15 00:00:00

  • Pharmacotherapy of depressed children and adolescents: current issues and potential directions.

    abstract::The recent deliberations by the U.S. Food and Drug Administration (FDA) regarding the relationship between antidepressants and suicidality in children have incited debates about the safety of these medications for the treatment of pediatric depression. In light of these events, this review discusses four issues pertai...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.biopsych.2005.10.010

    authors: Vasa RA,Carlino AR,Pine DS

    更新日期:2006-06-01 00:00:00

  • Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder.

    abstract:BACKGROUND:Posttraumatic stress disorder (PTSD) is associated with increased risk for age-related diseases and early mortality. An accelerated rate of biological aging could contribute to this increased risk. To investigate, we assessed leukocyte telomere length (LTL), an emerging marker of biological age, in men and w...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2011.01.035

    authors: O'Donovan A,Epel E,Lin J,Wolkowitz O,Cohen B,Maguen S,Metzler T,Lenoci M,Blackburn E,Neylan TC

    更新日期:2011-09-01 00:00:00

  • Adrenocortical function and plasma norepinephrine in normal human subjects.

    abstract::Abnormal adrenocortical regulation has been reported in patients with endogenous depression, including excessive cortisol production with loss of circadian periodicity and decreased suppression by dexamethasone. The inhibitory effect of the neurotransmitter norepinephrine (NE) on the hypothalamic-pituitary adrenal (HP...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Sotsky SM,Lake CR,Goodwin FK

    更新日期:1981-07-01 00:00:00

  • Learning and behavioral abnormalities in the seizure-prone baboon.

    abstract::A high incidence of behavioral and learning difficulties has been found in juvenile seizure-prone baboons presented with a graded series of operant behavioral task challenges. The animals fell into two distinct groups based upon the rate at which their operant performance was able to develop, the amount of day-to-day ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Weinberger SB,Killam EK

    更新日期:1979-06-01 00:00:00

  • Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia.

    abstract:BACKGROUND:Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and schizophrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and function of the hippocampus. Because positive symptoms in SZ h...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2006.07.023

    authors: DeRosse P,Hodgkinson CA,Lencz T,Burdick KE,Kane JM,Goldman D,Malhotra AK

    更新日期:2007-05-15 00:00:00

  • Cumulative alterations in rat behavior during continuous administration of LSD or mescaline: absence of tolerance?

    abstract::Male hooded rats were observed for 6 days following implantation with slow-release subcutaneous pellets containing LSD, mescaline, or control vehicle solution. In animals housed in isolation cages, continuous hallucinogen administration resulted in a gradual increase in head twitches and catatonic postures which peake...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Ellison G,Ring M,Ross D,Axelrood B

    更新日期:1980-02-01 00:00:00

  • Stress as a common risk factor for obesity and addiction.

    abstract::Stress is associated with obesity, and the neurobiology of stress overlaps significantly with that of appetite and energy regulation. This review will discuss stress, allostasis, the neurobiology of stress and its overlap with neural regulation of appetite, and energy homeostasis. Stress is a key risk factor in the de...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.biopsych.2013.01.032

    authors: Sinha R,Jastreboff AM

    更新日期:2013-05-01 00:00:00

  • Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users.

    abstract:BACKGROUND:Cannabis remains the most widely used illicit substance by adolescents and is typically consumed by this population in the context of ongoing tobacco use. Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects o...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2006.02.014

    authors: Jacobsen LK,Pugh KR,Constable RT,Westerveld M,Mencl WE

    更新日期:2007-01-01 00:00:00

  • Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers.

    abstract:BACKGROUND:The N-methyl-D-aspartate receptor antagonist, ketamine, produces a clinical syndrome of thought disorder, perceptual distortion, and cognitive impairment. METHODS:We have administered ketamine to healthy volunteers to characterize the formal thought disorder and specific memory dysfunction associated with k...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0006-3223(97)00556-8

    authors: Adler CM,Goldberg TE,Malhotra AK,Pickar D,Breier A

    更新日期:1998-06-01 00:00:00

  • A polymorphism in the dopamine beta-hydroxylase gene is associated with "paranoid ideation" in patients with major depression.

    abstract:BACKGROUND:Increased dopaminergic activity may play a primary role in psychotic depression. Dopamine beta-hydroxylase (DbetaH) catalyses the key step in biosynthesis of the neurotransmitter noradrenaline from dopamine, and low DbetaH activity is a possible risk factor for developing psychotic depression. An exon 2 poly...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(01)01367-1

    authors: Wood JG,Joyce PR,Miller AL,Mulder RT,Kennedy MA

    更新日期:2002-03-01 00:00:00

  • Effectiveness of chromium in atypical depression: a placebo-controlled trial.

    abstract:BACKGROUND:Chromium picolinate (CP) has been reported to benefit patients with symptoms of atypical depression. METHODS:A placebo-controlled, double-blind, pilot study of CP was conducted in 15 patients with DSM-IV major depressive disorder, atypical type. Patients received 600 micro g of CP or matching placebo (PBO) ...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0006-3223(02)01500-7

    authors: Davidson JR,Abraham K,Connor KM,McLeod MN

    更新日期:2003-02-01 00:00:00

  • The effect of tricyclic antidepressants on cerebral fluid dynamics.

    abstract::Tricyclic antidepressants are thought to act primarily via effects on adrenergic neurotransmitters. Recent research supports the concept that a major function of the central adrenergic system is the modulation of cerebral fluid dynamics. Based on this concept, studies in the rat were conducted to assess the effects of...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Preskorn SH,Hartman BK

    更新日期:1979-04-01 00:00:00

  • Platelet alpha-2-adrenergic dysfunction in negative symptom schizophrenia: a preliminary study.

    abstract::The specific binding to platelet membranes (Bmax) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment Bmax for 3H-clonidine showed a sign...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(85)90025-3

    authors: Rosen J,Silk KR,Rice HE,Smith CB

    更新日期:1985-05-01 00:00:00

  • Event-related brain potentials (ERPs) in schizophrenia for tonal and phonetic oddball tasks.

    abstract:BACKGROUND:Prior studies using simple target detection ("oddball") tasks with pure tones have reported asymmetric reduction of the P3 event-related potential (ERP). This study investigated the time course and topography of ERPs recorded during both tonal and phonetic oddball tasks. METHODS:Event-related potentials of ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(00)01090-8

    authors: Kayser J,Bruder GE,Tenke CE,Stuart BK,Amador XF,Gorman JM

    更新日期:2001-05-15 00:00:00

  • Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial.

    abstract:BACKGROUND:Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that intravenous administration of the N-methyl-D-aspartate antagonist ketamine produced rapid antidepressant effects in patients with treatment...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.biopsych.2011.12.010

    authors: Zarate CA Jr,Brutsche NE,Ibrahim L,Franco-Chaves J,Diazgranados N,Cravchik A,Selter J,Marquardt CA,Liberty V,Luckenbaugh DA

    更新日期:2012-06-01 00:00:00

  • Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.

    abstract:BACKGROUND:Neuregulin-1 (Nrg1) is a pleiotropic signaling molecule that regulates neural development, and mutation of Nrg1 is a risk factor for schizophrenia. Cleavage of type I β1 Nrg1 isoform by Bace1 releases a secreted N-terminal fragment (Nrg1-ntfβ), which can bind to a cognate ErbB receptor to activate the specif...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2013.09.026

    authors: Luo X,He W,Hu X,Yan R

    更新日期:2014-07-15 00:00:00

  • Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior.

    abstract:BACKGROUND:Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety- and depressive-like behaviors. Concomitantly, microglia in the PFC undergo morphological and functional changes following stress exposure, suggesting that micro...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2017.05.026

    authors: Wohleb ES,Terwilliger R,Duman CH,Duman RS

    更新日期:2018-01-01 00:00:00

  • Smaller orbital frontal cortex volumes associated with functional disability in depressed elders.

    abstract:BACKGROUND:Depression is associated with significant functional impairment. Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) and instrumental (IADL) activities of daily living. METHODS:The ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(02)01490-7

    authors: Taylor WD,Steffens DC,McQuoid DR,Payne ME,Lee SH,Lai TJ,Krishnan KR

    更新日期:2003-01-15 00:00:00

  • Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression.

    abstract:BACKGROUND:Recent postmortem studies demonstrate disrupted neurochemistry of the noradrenergic locus coeruleus (LC) in major depression (MD). Increased levels of tyrosine hydroxylase and decreased levels of norepinephrine transporter implicate a norepinephrine deficiency in the LC in MD. Here we describe a study of alp...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(02)01728-6

    authors: Ordway GA,Schenk J,Stockmeier CA,May W,Klimek V

    更新日期:2003-02-15 00:00:00

  • Eye Tracking Reveals Abnormal Visual Preference for Geometric Images as an Early Biomarker of an Autism Spectrum Disorder Subtype Associated With Increased Symptom Severity.

    abstract:BACKGROUND:Clinically and biologically, autism spectrum disorder (ASD) is heterogeneous. Unusual patterns of visual preference as indexed by eye tracking are hallmarks; however, whether they can be used to define an early biomarker of ASD as a whole or leveraged to define a subtype is unclear. To begin to examine this ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2015.03.032

    authors: Pierce K,Marinero S,Hazin R,McKenna B,Barnes CC,Malige A

    更新日期:2016-04-15 00:00:00

  • Hypothalamic-pituitary-adrenal axis dysregulation in dysphoric children and adolescents: cortisol reactivity to psychosocial stress from preschool through middle adolescence.

    abstract:BACKGROUND:Most depressed adults exhibit dysregulation of the hypothalamic-pituitary-adrenal axis, including cortisol hyperreactivity to psychosocial challenge. In contrast, remarkably little is known about hypothalamic-pituitary-adrenal axis activity in response to psychosocial challenge among at-risk children and ado...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2010.04.004

    authors: Hankin BL,Badanes LS,Abela JR,Watamura SE

    更新日期:2010-09-01 00:00:00

  • Iron, copper, zinc, magnesium, and calcium in postmortem brain tissue from schizophrenic patients.

    abstract::The regional distribution of iron, copper, zinc, magnesium, and calcium in postmortem brain of schizophrenic patients was compared with that of matched controls. In none of the brain regions investigated (caudate nucleus, hippocampus, amygdala, cortex, corpus mamillare, gyrus cinguli, and hypothalamus) were significan...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(94)90059-0

    authors: Kornhuber J,Lange KW,Kruzik P,Rausch WD,Gabriel E,Jellinger K,Riederer P

    更新日期:1994-07-01 00:00:00

  • Is treatment-resistant depression a unique subtype of depression?

    abstract::Treatment-resistant depression (TRD) continues to represent a major challenge for treating clinicians. This report reviews the relevant literature to evaluate whether TRD can be considered a specific subtype of depression based on 1) clinical characteristics and course (behavioral phenotype), 2) neurobiological profil...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/s0006-3223(02)01670-0

    authors: Fagiolini A,Kupfer DJ

    更新日期:2003-04-15 00:00:00

  • Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia.

    abstract:BACKGROUND:Problems with the voluntary control of behavior, such as those leading to increased antisaccade errors, are accepted as evidence of prefrontal dysfunction in schizophrenia. We previously reported that speeded prosaccade responses, i.e., shorter response latencies for automatic shifts of attention to visual t...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2007.11.009

    authors: Reilly JL,Harris MS,Khine TT,Keshavan MS,Sweeney JA

    更新日期:2008-04-15 00:00:00

  • Toward a generalizable model of symptoms in major depressive disorder.

    abstract:BACKGROUND:This study has two goals: 1) to establish a generalizable model of the symptoms observed in outpatients with major depressive disorder (MDD); and 2) to compare symptom coverage of the Inventory of Depressive Symptomatology, Clinician-Rated (IDS-C) and Self-Report (IDS-SR) to that of the Hamilton Depression R...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0006-3223(98)00235-2

    authors: Gullion CM,Rush AJ

    更新日期:1998-11-15 00:00:00