Abstract：
BACKGROUND:A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) allele showed stronger amygdala activation than long (l) carriers. However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers. METHODS:Functional MRI was used to assess amygdala activation during the presentation of a fixation cross or affectively aversive or neutral visual stimuli in 29 healthy men. RESULTS:Amygdala activation was increased in s carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions. CONCLUSIONS:This finding suggests that s carriers show stronger amygdala reactivity to stimuli and contexts that are relatively uncertain, which we propose are stressful.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Heinz A,Smolka MN,Braus DF,Wrase J,Beck A,Flor H,Mann K,Schumann G,Büchel C,Hariri AR,Weinberger DRdoi
10.1016/j.biopsych.2006.08.019subject
Has Abstractpub_date
2007-04-15 00:00:00pages
1011-4issue
8eissn
0006-3223issn
1873-2402pii
S0006-3223(06)01068-7journal_volume
61pub_type
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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更新日期：1999-10-01 00:00:00
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pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 评论,杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
