Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation.


BACKGROUND:A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) allele showed stronger amygdala activation than long (l) carriers. However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers. METHODS:Functional MRI was used to assess amygdala activation during the presentation of a fixation cross or affectively aversive or neutral visual stimuli in 29 healthy men. RESULTS:Amygdala activation was increased in s carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions. CONCLUSIONS:This finding suggests that s carriers show stronger amygdala reactivity to stimuli and contexts that are relatively uncertain, which we propose are stressful.


Biol Psychiatry


Biological psychiatry


Heinz A,Smolka MN,Braus DF,Wrase J,Beck A,Flor H,Mann K,Schumann G,Büchel C,Hariri AR,Weinberger DR




Has Abstract


2007-04-15 00:00:00














  • HPA axis dysregulation in mice overexpressing corticotropin releasing hormone.

    abstract:BACKGROUND:Hypersecretion of corticotropin-releasing hormone (CRH) in the brain has been implicated in stress-related human pathologies. We developed a transgenic mouse line overexpressing CRH (CRH-OE) exclusively in neural tissues to assess the effect of long-term CRH overproduction on regulation of the hypothalamic-p...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Groenink L,Dirks A,Verdouw PM,Schipholt Ml,Veening JG,van der Gugten J,Olivier B

    更新日期:2002-06-01 00:00:00

  • Diabetes, sleep disorders, and male sexual function.

    abstract::The prevalence and role of sleep disorders in the sexual problems of diabetic patients remain unexplored. This study was conducted on 40 diabetic men carefully screened to exclude the confounding effects of other medical illnesses or drugs likely to impair sexual function and 40 age-matched healthy volunteers. They un...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Schiavi RC,Stimmel BB,Mandeli J,Rayfield EJ

    更新日期:1993-08-01 00:00:00

  • Magnesium measures across the menstrual cycle in premenstrual syndrome.

    abstract::The purpose of this study was to evaluate blood magnesium (Mg) measures across the menstrual cycle in women with premenstrual syndrome (PMS) and control women. Longitudinal determinations of plasma, red blood cell (RBC) and mononuclear blood cell (MBC) Mg were made in 26 women with prospectively confirmed PMS and in a...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Rosenstein DL,Elin RJ,Hosseini JM,Grover G,Rubinow DR

    更新日期:1994-04-15 00:00:00

  • Familial and sporadic subtypes of early-onset Obsessive-Compulsive disorder.

    abstract:BACKGROUND:Family studies of Obsessive-Compulsive (OCD) indicate there is substantial heterogeneity in the familiality of the disorder. This study was done to determine whether there are differences between familial and sporadic probands with early-onset OCD in obsessive-compulsive (OC) symptom categories and comorbid ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Hanna GL,Fischer DJ,Chadha KR,Himle JA,Van Etten M

    更新日期:2005-04-15 00:00:00

  • Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users.

    abstract:BACKGROUND:Cannabis remains the most widely used illicit substance by adolescents and is typically consumed by this population in the context of ongoing tobacco use. Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects o...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Jacobsen LK,Pugh KR,Constable RT,Westerveld M,Mencl WE

    更新日期:2007-01-01 00:00:00

  • Activity-Regulated Cytoskeleton-Associated Protein Accumulates in the Nucleus in Response to Cocaine and Acts as a Brake on Chromatin Remodeling and Long-Term Behavioral Alterations.

    abstract:BACKGROUND:Addiction relies on persistent alterations of neuronal properties, which depends on gene regulation. Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying learning and memory. Its role in cocaine-induced neuronal and behavioral adapt...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Salery M,Dos Santos M,Saint-Jour E,Moumné L,Pagès C,Kappès V,Parnaudeau S,Caboche J,Vanhoutte P

    更新日期:2017-04-01 00:00:00

  • Nitrous oxide and xenon prevent amphetamine-induced carrier-mediated dopamine release in a memantine-like fashion and protect against behavioral sensitization.

    abstract:BACKGROUND:Amphetamine administration induces stimulation-independent dopamine release in the nucleus accumbens (NAcc) through reverse dopamine transport, a critical neurochemical event involved in its psychostimulant action, and furthermore decreases stimulation-dependent vesicular dopamine release. These effects may ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: David HN,Ansseau M,Lemaire M,Abraini JH

    更新日期:2006-07-01 00:00:00

  • Dopaminergic Disturbances in Tourette Syndrome: An Integrative Account.

    abstract::Tourette syndrome (TS) is thought to involve dopaminergic disturbances, but the nature of those disturbances remains controversial. Existing hypotheses suggest that TS involves 1) supersensitive dopamine receptors, 2) overactive dopamine transporters that cause low tonic but high phasic dopamine, 3) presynaptic dysfun...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Maia TV,Conceição VA

    更新日期:2018-09-01 00:00:00

  • Autoimmunity, inflammation, and psychosis: a search for peripheral markers.

    abstract::Accumulating evidence supports the view that deregulation of the immune system represents an important vulnerability factor for psychosis. In a subgroup of psychotic patients, the high comorbidity with autoimmune and chronic inflammatory conditions suggests a common underlying immune abnormality leading to both condit...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Bergink V,Gibney SM,Drexhage HA

    更新日期:2014-02-15 00:00:00

  • Brainstem correlates of defensive states in humans.

    abstract:BACKGROUND:Brainstem auditory evoked potentials (BAEP) reflect the activation of brainstem nuclei in the first milliseconds after presentation of an auditory stimulus. These electrophysiological correlates of neural processing are highly automatic and not influenced by cognitive factors or task demands; however, data f...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Baas JM,Milstein J,Donlevy M,Grillon C

    更新日期:2006-04-01 00:00:00

  • Toward a generalizable model of symptoms in major depressive disorder.

    abstract:BACKGROUND:This study has two goals: 1) to establish a generalizable model of the symptoms observed in outpatients with major depressive disorder (MDD); and 2) to compare symptom coverage of the Inventory of Depressive Symptomatology, Clinician-Rated (IDS-C) and Self-Report (IDS-SR) to that of the Hamilton Depression R...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Gullion CM,Rush AJ

    更新日期:1998-11-15 00:00:00

  • Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial.

    abstract:BACKGROUND:Selective localization of dopamine D(4) receptors in the prefrontal cortex and preferential affinity of clozapine for the dopamine D(4) receptor over the D(2) receptor led to the hypothesis that the superior efficacy of clozapine may be mediated via blockade of the D(4) receptor. This hypothesis was tested b...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Corrigan MH,Gallen CC,Bonura ML,Merchant KM,Sonepiprazole Study Group.

    更新日期:2004-03-01 00:00:00

  • Event-related potential evidence of dysfunction in automatic processing in abstinent alcoholics.

    abstract::The preattentive automatic processing of 63 alcoholics and 27 controls was evaluated with an auditory inattentive event-related oddball paradigm. We examined the mismatch negativity and the N2-P3 complex. Results showed significantly greater amplitude for N2, P3 and the N2-P3 complex for controls but no individual lea...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Realmuto G,Begleiter H,Odencrantz J,Porjesz B

    更新日期:1993-04-15 00:00:00

  • Concurrent validation of schizotaxia: a pilot study.

    abstract:BACKGROUND:Many first-degree relatives of patients with schizophrenia show deficits in clinical, neuropsychological, neurobiological and social domains, in the absence of psychosis. We recently reformulated Meehl's concept of schizotaxia to conceptualize the liability to schizophrenia, and we proposed preliminary crite...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Stone WS,Faraone SV,Seidman LJ,Green AI,Wojcik JD,Tsuang MT

    更新日期:2001-09-15 00:00:00

  • Ritanserin in the treatment of cocaine dependence.

    abstract::Sixty-five cocaine-dependent subjects were enrolled into a 10-week randomized, double-blind study to determine the safety and efficacy of the serotonin-2 receptor antagonist, ritanserin (10 mg/day), in reducing cocaine consumption and craving. All subjects also participated in a structured intensive outpatient psychos...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Johnson BA,Chen YR,Swann AC,Schmitz J,Lesser J,Ruiz P,Johnson P,Clyde C

    更新日期:1997-11-15 00:00:00

  • Effective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients.

    abstract:BACKGROUND:The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuro...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Weike AI,Bauer U,Hamm AO

    更新日期:2000-01-01 00:00:00

  • Reciprocal Copy Number Variations at 22q11.2 Produce Distinct and Convergent Neurobehavioral Impairments Relevant for Schizophrenia and Autism Spectrum Disorder.

    abstract:BACKGROUND:22q11.2 deletions and duplications are copy number variations (CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confers disproportionate risk for schizophrenia. Neurobehavioral profiles associated with these re...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Lin A,Vajdi A,Kushan-Wells L,Helleman G,Hansen LP,Jonas RK,Jalbrzikowski M,Kingsbury L,Raznahan A,Bearden CE

    更新日期:2020-08-01 00:00:00

  • Maternal prenatal cortisol and infant cognitive development: moderation by infant-mother attachment.

    abstract:BACKGROUND:Experimental animal studies suggest that early glucocorticoid exposure may have lasting effects on the neurodevelopment of the offspring; animal studies also suggest that this effect may be eliminated by positive postnatal rearing. The relevance of these findings to humans is not known. METHODS:We prospecti...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Bergman K,Sarkar P,Glover V,O'Connor TG

    更新日期:2010-06-01 00:00:00

  • Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.

    abstract:BACKGROUND:Recent findings indicate that inhibitors of fatty acid amide hydrolase (FAAH) counteract the rewarding effects of nicotine in rats. Inhibition of FAAH increases levels of several endogenous substances in the brain, including the endocannabinoid anandamide and the noncannabinoid fatty acid ethanolamides oleoy...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Mascia P,Pistis M,Justinova Z,Panlilio LV,Luchicchi A,Lecca S,Scherma M,Fratta W,Fadda P,Barnes C,Redhi GH,Yasar S,Le Foll B,Tanda G,Piomelli D,Goldberg SR

    更新日期:2011-04-01 00:00:00

  • Attention-deficit/hyperactivity disorder: a selective overview.

    abstract::Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial and clinically heterogeneous disorder that is associated with tremendous financial burden, stress to families, and adverse academic and vocational outcomes. Attention-deficit/hyperactivity disorder is highly prevalent in children worldwide, and the pr...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Biederman J

    更新日期:2005-06-01 00:00:00

  • A randomized double-blind fluvoxamine/placebo crossover trial in pathologic gambling.

    abstract:BACKGROUND:The study assessed the efficacy and tolerability of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine in the treatment of pathologic gambling (PG). METHODS:A 16-week randomized double-blind crossover design insured that each subject received 8 weeks of fluvoxamine and 8 weeks of a placebo. Fifte...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hollander E,DeCaria CM,Finkell JN,Begaz T,Wong CM,Cartwright C

    更新日期:2000-05-01 00:00:00

  • A placebo controlled trial of bupropion for smoking cessation in schizophrenia.

    abstract:BACKGROUND:Schizophrenic patients have high rates of cigarette smoking compared with the general population. We compared sustained-release (SR) bupropion with placebo for smoking cessation in patients with schizophrenic disorders. We also examined how antipsychotic class predicts smoking cessation outcomes with bupropi...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: George TP,Vessicchio JC,Termine A,Bregartner TA,Feingold A,Rounsaville BJ,Kosten TR

    更新日期:2002-07-01 00:00:00

  • Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures.

    abstract:BACKGROUND:Methylphenidate has been shown elsewhere to improve hyperactivity in about half of treated children who have pervasive developmental disorders (PDD) and significant hyperactive-inattentive symptoms. We present secondary analyses to better define the scope of effects of methylphenidate on symptoms that define...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Posey DJ,Aman MG,McCracken JT,Scahill L,Tierney E,Arnold LE,Vitiello B,Chuang SZ,Davies M,Ramadan Y,Witwer AN,Swiezy NB,Cronin P,Shah B,Carroll DH,Young C,Wheeler C,McDougle CJ

    更新日期:2007-02-15 00:00:00

  • Attention Alterations in Pediatric Anxiety: Evidence From Behavior and Neuroimaging.

    abstract:BACKGROUND:Pediatric anxiety disorders involve greater capture of attention by threatening stimuli. However, it is not known if disturbances extend to nonthreatening stimuli, as part of a pervasive disturbance in attention-related brain systems. We hypothesized that pediatric anxiety involves greater capture of attenti...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Perino MT,Yu Q,Myers MJ,Harper JC,Baumel WT,Petersen SE,Barch DM,Luby JL,Sylvester CM

    更新日期:2020-08-01 00:00:00

  • Auditory sensory processing in autism: a magnetoencephalographic study.

    abstract:BACKGROUND:Patients with autism show clinical features suggestive of abnormal processing of auditory and other sensory information. We hypothesized that low-functioning autistic subjects present abnormalities in discriminating simple auditory stimuli at sensory system preconscious stages of cortical processing. METHOD...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Tecchio F,Benassi F,Zappasodi F,Gialloreti LE,Palermo M,Seri S,Rossini PM

    更新日期:2003-09-15 00:00:00

  • Possible association of QTc interval prolongation with co-administration of quetiapine and lovastatin.

    abstract:BACKGROUND:QTc interval prolongation can occur as a result of treatment with both conventional and novel antipsychotic medications and is of clinical concern because of its association with the potentially fatal ventricular arrhythmia, torsade de pointes. METHODS:One case is described in which a patient with schizophr...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Furst BA,Champion KM,Pierre JM,Wirshing DA,Wirshing WC

    更新日期:2002-02-01 00:00:00

  • Epidemiology and natural history of schizophrenia.

    abstract::The present review explores the descriptive epidemiology of schizophrenia. Risk factors and correlates are divided into three groups based on whether the available evidence is consistent and strong, consistent and potentially strong, or inconsistent. The paper then considers epidemiologic studies of the course of illn...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Bromet EJ,Fennig S

    更新日期:1999-10-01 00:00:00

  • Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter.

    abstract:BACKGROUND:Structural MRI data indicate schizophrenics have reduced left-sided temporal lobe gray matter volumes, especially in the superior temporal gyrus (STG) and medial temporal lobe. Our data further suggest a specificity to schizophrenia spectrum disorders of STG volume reduction. Interpretation of research studi...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Dickey CC,McCarley RW,Voglmaier MM,Niznikiewicz MA,Seidman LJ,Hirayasu Y,Fischer I,Teh EK,Van Rhoads R,Jakab M,Kikinis R,Jolesz FA,Shenton ME

    更新日期:1999-06-01 00:00:00

  • Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology?

    abstract::The diagnosis of schizophrenia rests on clinical criteria that cannot be assessed in animal models. Together with absence of a clear underlying pathology and understanding of what causes schizophrenia, this has hindered development of informative animal models. However, recent large-scale genomic studies have identifi...

    journal_title:Biological psychiatry

    pub_type: 评论,杂志文章,评审


    authors: Forsingdal A,Jørgensen TN,Olsen L,Werge T,Didriksen M,Nielsen J

    更新日期:2019-01-01 00:00:00

  • Probing Brain Developmental Patterns of Myelination and Associations With Psychopathology in Youths Using Gray/White Matter Contrast.

    abstract:BACKGROUND:Cerebral myeloarchitecture shows substantial development across childhood and adolescence, and aberrations in these trajectories are relevant for a range of mental disorders. Differential myelination between intracortical and subjacent white matter can be approximated using signal intensities in T1-weighted ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Norbom LB,Doan NT,Alnæs D,Kaufmann T,Moberget T,Rokicki J,Andreassen OA,Westlye LT,Tamnes CK

    更新日期:2019-03-01 00:00:00