Abstract:
BACKGROUND:Why do we jump the gun or speak out of turn? Waiting impulsivity has a preclinical basis as a predictor for the development of addiction. Here, we mapped the intrinsic neural correlates of waiting and dissociated it from stopping, both fundamental mechanisms of behavioral control. METHODS:We used a recently developed translational task to assess premature responding and assess response inhibition using the stop signal task. We mapped the neural correlates in 55 healthy volunteers using a novel multi-echo resting-state functional magnetic resonance imaging sequence and analysis, which robustly boosts signal-to-noise ratio. We further assessed 32 young binge drinkers and 36 abstinent subjects with alcohol use disorders. RESULTS:Connectivity of limbic and motor cortical and striatal nodes mapped onto a mesial-lateral axis of the subthalamic nucleus. Waiting impulsivity was associated with lower connectivity of the subthalamic nucleus with ventral striatum and subgenual cingulate, regions similarly implicated in rodent lesion studies. This network was dissociable from fast reactive stopping involving hyperdirect connections of the pre-supplementary area and subthalamic nucleus. We further showed that binge drinkers, like those with alcohol use disorders, had elevated premature responding and emphasized the relevance of this subthalamic network across alcohol misuse. Using machine learning techniques we showed that subthalamic connectivity differentiates binge drinkers and individuals with alcohol use disorders from healthy volunteers. CONCLUSIONS:We highlight the translational and clinical relevance of dissociable functional systems of cortical, striatal, and hyperdirect connections with the subthalamic nucleus in modulating waiting and stopping and their importance across dimensions of alcohol misuse.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Morris LS,Kundu P,Baek K,Irvine MA,Mechelmans DJ,Wood J,Harrison NA,Robbins TW,Bullmore ET,Voon Vdoi
10.1016/j.biopsych.2015.06.009subject
Has Abstractpub_date
2016-03-15 00:00:00pages
499-507issue
6eissn
0006-3223issn
1873-2402pii
S0006-3223(15)00483-7journal_volume
79pub_type
杂志文章abstract:BACKGROUND:We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD). METHODS:Positron emission tomography with [(15)O] water measured alterations of regional cerebral blood flow (rCBF) d...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2013-08-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
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journal_title:Biological psychiatry
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更新日期:2009-06-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(97)00017-6
更新日期:1997-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2003.09.013
更新日期:2004-02-15 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1998-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(00)01049-0
更新日期:2001-04-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2007.01.008
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2005.05.007
更新日期:2005-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:1996-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,随机对照试验
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更新日期:2012-03-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/S0006-3223(96)00114-X
更新日期:1997-03-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.10.027
更新日期:2007-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90091-y
更新日期:1991-03-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2020.07.016
更新日期:2020-08-01 00:00:00