Abstract：
:Several findings support the hypothesis that the striatum is implicated in executive functions and in the modulation of goal-directed behavior, and could play a key role in the pathophysiology and in the production of symptoms and signs in schizophrenia. We have studied the relationship between the objective measures of the striatal structures, as evaluated by magnetic resonance imaging (MRI), and the Wisconsin Card Sorting Test (WCST) performance in a schizophrenic sample. Thirty-five schizophrenic patients underwent MRI scans of striatal structure and neuropsychological evaluation of executive functions by WCST. Poor WCST performers had a reduction of the left caudate nucleus and putamen, and right total striatum when compared to 24 healthy controls. Significant correlation coefficients were also observed between neuropsychological indexes and left striatal measures. The findings suggest the existence of a relationship between abnormalities of striatal structure and abnormal executive-type or organizational cognitive functions.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Stratta P,Mancini F,Mattei P,Daneluzzo E,Casacchia M,Rossi Adoi
10.1016/s0006-3223(97)00017-6subject
Has Abstractpub_date
1997-11-01 00:00:00pages
816-20issue
9eissn
0006-3223issn
1873-2402pii
S0006-3223(97)00017-6journal_volume
42pub_type
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journal_title：Biological psychiatry
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doi：
更新日期：1980-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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journal_title：Biological psychiatry
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doi：
更新日期：1982-06-01 00:00:00
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.11.022
更新日期：2008-05-15 00:00:00
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journal_title：Biological psychiatry
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doi：
更新日期：1981-12-01 00:00:00
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pub_type： 杂志文章,收录出版
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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更新日期：2010-03-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2000-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1991-02-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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