Abstract：
BACKGROUND:Acute ketamine has been shown to model features of schizophrenia such as psychotic symptoms, cognitive deficits and smooth pursuit eye movement dysfunction. There have been suggestions that chronic ketamine may also produce an analogue of the disorder. In this study, we investigated the effect of persistent recreational ketamine use on tests of episodic and working memory and on oculomotor tasks of smooth pursuit and pro- and antisaccades. METHODS:Twenty ketamine users were compared with 1) 20 first-episode schizophrenia patients, 2) 17 polydrug control subjects who did not use ketamine but were matched to the ketamine users for other drug use, and 3) 20 non-drug-using control subjects. All groups were matched for estimated premorbid IQ. RESULTS:Ketamine users made more antisaccade errors than both control groups but did not differ from patients. Ketamine users performed better than schizophrenia patients on smooth pursuit, antisaccade metrics, and both memory tasks but did not differ from control groups. CONCLUSIONS:Problems inhibiting reflexive eye movements may be a consequence of repeated ketamine self-administration. The absence of any other oculomotor or cognitive deficit present in schizophrenia suggests that chronic self-administration of ketamine may not be a good model of these aspects of the disorder.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Morgan CJ,Huddy V,Lipton M,Curran HV,Joyce EMdoi
10.1016/j.biopsych.2008.10.045subject
Has Abstractpub_date
2009-06-15 00:00:00pages
1099-102issue
12eissn
0006-3223issn
1873-2402pii
S0006-3223(08)01401-7journal_volume
65pub_type
杂志文章abstract：:Disturbances in dopaminergic transmission have been implicated in the etiology of psychotic disorders. Interindividual differences in deoxyribonucleic acid (DNA) sequences coding for dopamine receptor proteins might contribute to the genetic background of these diseases. We have identified a variation in exon 1 of the...
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pub_type： 杂志文章,评审
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更新日期：1997-06-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：1993-10-15 00:00:00
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doi：
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
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更新日期：2019-03-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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