当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Greater cortical gray matter density in lithium-treated patients with bipolar disorder.

Greater cortical gray matter density in lithium-treated patients with bipolar disorder.

Abstract：

BACKGROUND:The neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures. METHODS:We used high-resolution magnetic resonance imaging and cortical pattern matching methods to map gray matter differences in 28 adults with bipolar disorder, 70% of whom were lithium-treated (mean age = 36.1 +/- 10.5; 13 female subject), and 28 healthy control subjects (mean age = 35.9 +/- 8.5; 11 female subjects). Detailed spatial analyses of gray matter density (GMD) were conducted by measuring local proportions of gray matter at thousands of homologous cortical locations. RESULTS:Gray matter density was significantly greater in bipolar patients relative to control subjects in diffuse cortical regions. Greatest differences were found in bilateral cingulate and paralimbic cortices, brain regions critical for attentional, motivational, and emotional modulation. Secondary region of interest (ROI) analyses indicated significantly greater GMD in the right anterior cingulate among lithium-treated bipolar patients (n = 20) relative to those not taking lithium (n = 8). CONCLUSIONS:These brain maps are consistent with previous voxel-based morphometry reports of greater GMD in portions of the anterior limbic network in bipolar patients and suggest neurotrophic effects of lithium as a possible etiology of these neuroanatomic differences.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Bearden CE,Thompson PM,Dalwani M,Hayashi KM,Lee AD,Nicoletti M,Trakhtenbroit M,Glahn DC,Brambilla P,Sassi RB,Mallinger AG,Frank E,Kupfer DJ,Soares JC

doi

10.1016/j.biopsych.2006.10.027

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

7-16

issue

1

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(06)01368-0

journal_volume

62

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Maternal prenatal cortisol and infant cognitive development: moderation by infant-mother attachment.

    abstract：BACKGROUND:Experimental animal studies suggest that early glucocorticoid exposure may have lasting effects on the neurodevelopment of the offspring; animal studies also suggest that this effect may be eliminated by positive postnatal rearing. The relevance of these findings to humans is not known. METHODS:We prospecti...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.01.002

    authors： Bergman K,Sarkar P,Glover V,O'Connor TG

    更新日期：2010-06-01 00:00:00

  • Fearful imagery in social phobia: generalization, comorbidity, and physiological reactivity.

    abstract：BACKGROUND:Social phobia has been characterized as a disorder of exaggerated fear of social threat and heightened sensitivity to imagery of social failure. METHODS:To assess the physiological basis of this description, social phobia patients (n=75) and demographically matched control participants (n=75) imagined neutr...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.09.023

    authors： McTeague LM,Lang PJ,Laplante MC,Cuthbert BN,Strauss CC,Bradley MM

    更新日期：2009-03-01 00:00:00

  • No neural evidence of statistical learning during exposure to artificial languages in children with autism spectrum disorders.

    abstract：BACKGROUND:Language delay is a hallmark feature of autism spectrum disorders (ASD). The identification of word boundaries in continuous speech is a critical first step in language acquisition that can be accomplished via statistical learning and reliance on speech cues. Importantly, early word segmentation skills have ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.01.011

    authors： Scott-Van Zeeland AA,McNealy K,Wang AT,Sigman M,Bookheimer SY,Dapretto M

    更新日期：2010-08-15 00:00:00

  • Cognitive frontal lobe dysfunction in obsessive-compulsive disorder.

    abstract：BACKGROUND:There is evidence that dysfunction within associative frontostriatal circuits represents a feature of obsessive-compulsive disorder (OCD). Previous neuropsychologic studies have yielded diverging results, which may in part be explained by differences in the selection of subjects and methods. The present stud...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(97)00355-7

    authors： Schmidtke K,Schorb A,Winkelmann G,Hohagen F

    更新日期：1998-05-01 00:00:00

  • Probing Brain Developmental Patterns of Myelination and Associations With Psychopathology in Youths Using Gray/White Matter Contrast.

    abstract：BACKGROUND:Cerebral myeloarchitecture shows substantial development across childhood and adolescence, and aberrations in these trajectories are relevant for a range of mental disorders. Differential myelination between intracortical and subjacent white matter can be approximated using signal intensities in T1-weighted ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2018.09.027

    authors： Norbom LB,Doan NT,Alnæs D,Kaufmann T,Moberget T,Rokicki J,Andreassen OA,Westlye LT,Tamnes CK

    更新日期：2019-03-01 00:00:00

  • In search of multimodal neuroimaging biomarkers of cognitive deficits in schizophrenia.

    abstract：BACKGROUND:The cognitive deficits of schizophrenia are largely resistant to current treatments and thus are a lifelong illness burden. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) provides a reliable and valid assessment of cognition across ma...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.02.017

    authors： Sui J,Pearlson GD,Du Y,Yu Q,Jones TR,Chen J,Jiang T,Bustillo J,Calhoun VD

    更新日期：2015-12-01 00:00:00

  • AMPA Receptor Plasticity in Accumbens Core Contributes to Incubation of Methamphetamine Craving.

    abstract：BACKGROUND:The incubation of cue-induced drug craving in rodents provides a model of persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (NAc) core synapses through incorporation of Ca2+-permeable alpha-ami...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2016.04.003

    authors： Scheyer AF,Loweth JA,Christian DT,Uejima J,Rabei R,Le T,Dolubizno H,Stefanik MT,Murray CH,Sakas C,Wolf ME

    更新日期：2016-11-01 00:00:00

  • Auditory sensory processing in autism: a magnetoencephalographic study.

    abstract：BACKGROUND:Patients with autism show clinical features suggestive of abnormal processing of auditory and other sensory information. We hypothesized that low-functioning autistic subjects present abnormalities in discriminating simple auditory stimuli at sensory system preconscious stages of cortical processing. METHOD...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00295-6

    authors： Tecchio F,Benassi F,Zappasodi F,Gialloreti LE,Palermo M,Seri S,Rossini PM

    更新日期：2003-09-15 00:00:00

  • The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study.

    abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) and tic disorders have phenomenological and familial-genetic overlaps. An OCD family study sample that excludes Tourette's syndrome in probands is used to examine whether tic disorders are part of the familial phenotype of OCD. METHODS:Eighty case and 73 control probands ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(01)01074-5

    authors： Grados MA,Riddle MA,Samuels JF,Liang KY,Hoehn-Saric R,Bienvenu OJ,Walkup JT,Song D,Nestadt G

    更新日期：2001-10-15 00:00:00

  • Catecholamines in the bed nucleus of the stria terminalis reciprocally respond to reward and aversion.

    abstract：BACKGROUND:Traditionally, norepinephrine has been associated with stress responses, whereas dopamine has been associated with reward. Both of these catecholamines are found within the bed nucleus of the stria terminalis (BNST), a brain relay nucleus in the extended amygdala between cortical/limbic centers, and the hypo...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.10.017

    authors： Park J,Wheeler RA,Fontillas K,Keithley RB,Carelli RM,Wightman RM

    更新日期：2012-02-15 00:00:00

  • Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention.

    abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder characterized by deficits in attention, increased motor impulsivity, and hyperactivity. Preliminary work in mice and humans has suggested the X-linked gene STS (which encodes the enzyme steroid sulfatase) as a mediator o...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.01.001

    authors： Davies W,Humby T,Kong W,Otter T,Burgoyne PS,Wilkinson LS

    更新日期：2009-08-15 00:00:00

  • Perfusion abnormalities and decision making in cocaine dependence.

    abstract：BACKGROUND:Previous studies have shown that cocaine abusers have cerebral perfusion deficits that may diminish cognitive functioning. This study examined whether cocaine-dependent patients have perfusion abnormalities associated with poor decision-making ability as measured by the Iowa Gambling Task (IGT). METHODS:Sev...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.biopsych.2004.06.031

    authors： Tucker KA,Potenza MN,Beauvais JE,Browndyke JN,Gottschalk PC,Kosten TR

    更新日期：2004-10-01 00:00:00

  • Pharmacologic strategies for augmenting cognitive performance in schizophrenia.

    abstract：:There is recognition that the cognitive symptoms of schizophrenia have the most substantial impact on illness outcome. Domains of cognition reported to be significantly affected include serial learning, executive function, vigilance, and distractibility, to name a few. Dopamine activity at D1 receptors mediates many c...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(98)00287-x

    authors： Friedman JI,Temporini H,Davis KL

    更新日期：1999-01-01 00:00:00

  • Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice.

    abstract：BACKGROUND:Degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in the brain, occurs early and is ubiquitous in Alzheimer's disease (AD). Experimental lesions to the LC exacerbate AD-like neuropathology and cognitive deficits in several transgenic mouse models of AD. Because the LC contains multipl...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.06.013

    authors： Hammerschmidt T,Kummer MP,Terwel D,Martinez A,Gorji A,Pape HC,Rommelfanger KS,Schroeder JP,Stoll M,Schultze J,Weinshenker D,Heneka MT

    更新日期：2013-03-01 00:00:00

  • Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories.

    abstract：BACKGROUND:A method that promotes the retrieval of lost long-term memories has not been well established. Histamine in the central nervous system is implicated in learning and memory, and treatment with antihistamines impairs learning and memory. Because histamine H3 receptor inverse agonists upregulate histamine relea...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2018.11.009

    authors： Nomura H,Mizuta H,Norimoto H,Masuda F,Miura Y,Kubo A,Kojima H,Ashizuka A,Matsukawa N,Baraki Z,Hitora-Imamura N,Nakayama D,Ishikawa T,Okada M,Orita K,Saito R,Yamauchi N,Sano Y,Kusuhara H,Minami M,Takahashi H,Ikeg

    更新日期：2019-08-01 00:00:00

  • Increased cerebrospinal fluid glutamine levels in depressed patients.

    abstract：BACKGROUND:There is increasing evidence for an association between alterations of brain glutamatergic neurotransmission and the pathophysiology of affective disorders. METHODS:We studied the association between cerebrospinal fluid (CSF) metabolites, including glutamine, in unipolar and bipolar depressed patients versu...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00284-x

    authors： Levine J,Panchalingam K,Rapoport A,Gershon S,McClure RJ,Pettegrew JW

    更新日期：2000-04-01 00:00:00

  • Central tryptamine turnover in depression, schizophrenia, and anorexia: measurement of indoleacetic acid in cerebrospinal fluid.

    abstract：:There has been a continuing interest in the possible role of the trace amine tryptamine in the etiology of neuropsychiatric disorders. We have therefore examined cerebrospinal fluid (CSF) levels of indole-3-acetic acid (IAA), the major metabolite of tryptamine, in a large group of normals and in several patient popula...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Anderson GM,Gerner RH,Cohen DJ,Fairbanks L

    更新日期：1984-10-01 00:00:00

  • Hyperkinesis treated by vestibular stimulation: an exploratory study.

    abstract：:In crossover design with alternate assignment to order, 18 hyperkinetic children were treated with eyes-open rotational vestibular stimulation and with control contact, each eight times over 4-week periods. On behavioral ratings by teachers, they scored better after eight sessions of rotational stimulation than after ...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：

    authors： Bhatara V,Clark DL,Arnold LE,Gunsett R,Smeltzer DJ

    更新日期：1981-03-01 00:00:00

  • PET in generalized anxiety disorder.

    abstract：:Positron emission tomography (PET) measurements of cerebral glucose use were made in 18 patients with generalized anxiety disorder (GAD) during a passive viewing task off medication, and an active vigilance viewing task before and after medication or placebo treatment. In the passive viewing task, patients with GAD we...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0006-3223(91)90326-h

    authors： Wu JC,Buchsbaum MS,Hershey TG,Hazlett E,Sicotte N,Johnson JC

    更新日期：1991-06-15 00:00:00

  • Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia.

    abstract：:The etiology of Alzheimer's dementia (AD) is unknown, but several neurotransmitters, e.g., acetylcholine, have been implicated. Recently, the group of calcium channel antagonists have been reviewed for their potential neuropsychiatric applications. These agents are capable of enhancing cholinergic tone, neurofilament/...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/0006-3223(90)90050-c

    authors： Tollefson GD

    更新日期：1990-05-15 00:00:00

  • Association between amino acid alterations and hallucinations in alcoholic patients.

    abstract：:Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma rat...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(85)90175-1

    authors： Branchey L,Branchey M,Worner TM,Zucker D,Shaw S,Lieber CS

    更新日期：1985-11-01 00:00:00

  • Behavioral stress-induced activation of FoxO3a in the cerebral cortex of mice.

    abstract：BACKGROUND:The transcription factor FoxO3a is highly expressed in brain, but little is known about the response of FoxO3a to behavioral stress and its impact in the associated behavioral changes. METHODS:We tested the response of brain FoxO3a in the learned helplessness (LH) paradigm and tested signaling pathways that...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.08.012

    authors： Zhou W,Chen L,Yang S,Li F,Li X

    更新日期：2012-04-01 00:00:00

  • Is computerized tomography ventricular abnormality related to cycloid psychosis?

    abstract：:Twenty-eight psychiatric patients with computerized tomography (CT) findings of ventricular abnormality most likely to result from prenatal/perinatal lesions (VA group) were compared to 28 sex- and age-matched psychiatric patients with normal neuroradiological findings (NCT group). The neuroradiological rater was blin...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0006-3223(95)00623-0

    authors： Franzek E,Becker T,Hofmann E,Flöhl W,Stöber G,Beckmann H

    更新日期：1996-12-15 00:00:00

  • The effects of antidepressants on the thyroid axis in depression.

    abstract：:Thirty-nine patients with major depression were studied to determine the differential effects of desipramine (DMI) and fluoxetine (FLU) on thyroid hormones. Twenty-six percent showed some abnormality in baseline thyroid hormone levels. There were no demonstrable differences for any of the thyroid indices from baseline...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(93)90311-z

    authors： Shelton RC,Winn S,Ekhatore N,Loosen PT

    更新日期：1993-01-15 00:00:00

  • Depression, mortality, and medical morbidity in patients with coronary heart disease.

    abstract：:There is substantial evidence that depression is a risk factor for cardiac morbidity and mortality, both for patients without clinical evidence of coronary heart disease at index examination and for patients with established coronary disease. The relationship is most apparent for patients with a recent acute myocardia...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(03)00111-2

    authors： Carney RM,Freedland KE

    更新日期：2003-08-01 00:00:00

  • Reduced cerebrospinal fluid dynorphin A1-8 in Alzheimer's disease.

    abstract：:Cerebrospinal fluid (CSF) measures of dynorphin A were compared in three groups. Alzheimer patients (n = 9), elderly depressives (n = 9), and age-matched normal controls (n = 9). The Alzheimer patients revealed a 40% decrease in CSF dynorphin compared with controls (36 +/- 15 versus 60 +/- 21 pg/ml, p less than 0.05)....

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90073-u

    authors： Sunderland T,Berrettini WH,Molchan SE,Lawlor BA,Martinez RA,Vitiello B,Tariot PN,Cohen RM

    更新日期：1991-07-01 00:00:00

  • The changing roles and targets for animal models of schizophrenia.

    abstract：:Unlike disorders of other fields of medicine (eg., diabetes, heart disease), schizophrenia has been only marginally impacted by the study of animal models. This gap reflects the incomplete understanding of the causes and mechanisms of schizophrenia and the resulting lack of defined targets for model development. Howev...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(01)01286-0

    authors： Kilts CD

    更新日期：2001-12-01 00:00:00

  • Autism-associated haplotype affects the regulation of the homeobox gene, ENGRAILED 2.

    abstract：BACKGROUND:Association analysis identified the homeobox transcription factor, ENGRAILED 2 (EN2), as a possible autism spectrum disorder (ASD) susceptibility gene (ASD [MIM 608636]; EN2 [MIM 131310]). The common alleles (underlined) of two intronic single nucleotide polymorphisms (SNPs), rs1861972 (A/G) and rs1861973 (C...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.05.027

    authors： Benayed R,Choi J,Matteson PG,Gharani N,Kamdar S,Brzustowicz LM,Millonig JH

    更新日期：2009-11-15 00:00:00

  • HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression.

    abstract：BACKGROUND:Recent evidence indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to increasing levels of stressful life events than do individuals who have ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2007.10.008

    authors： Gotlib IH,Joormann J,Minor KL,Hallmayer J

    更新日期：2008-05-01 00:00:00

  • Sleep electroencephalographic response to muscarinic and serotonin1A receptor probes in patients with major depression and in normal controls.

    abstract：BACKGROUND:To test the hypothesis that depression is associated with an increased ratio of cholinergic to serotonergic neurotransmission, we compared the effects of pilocarpine, a muscarinic agonist, and ipsapirone, a serotonin (5-HT)1A agonist, on electroencephalographic (EEG) sleep in depressed and healthy subjects. ...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(97)00551-9

    authors： Seifritz E,Gillin JC,Rapaport MH,Kelsoe JR,Bhatti T,Stahl SM

    更新日期：1998-07-01 00:00:00