Increased cerebrospinal fluid glutamine levels in depressed patients.

abstract：:Cerebrospinal fluid (CSF) concentrations of the serotonin and dopamine metabolites, 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA), respectively, were measured in a group of 17 children with Autistic Disorder (DSM-III-R). The group means observed for 5HIAA (135 +/- 91 nmol/L) and HVA (502 +/- 324 nmol/...

journal_title：Biological psychiatry

authors： Narayan M,Srinath S,Anderson GM,Meundi DB

更新日期：1993-04-15 00:00:00

abstract：BACKGROUND:A method that promotes the retrieval of lost long-term memories has not been well established. Histamine in the central nervous system is implicated in learning and memory, and treatment with antihistamines impairs learning and memory. Because histamine H3 receptor inverse agonists upregulate histamine relea...

journal_title：Biological psychiatry

authors： Nomura H,Mizuta H,Norimoto H,Masuda F,Miura Y,Kubo A,Kojima H,Ashizuka A,Matsukawa N,Baraki Z,Hitora-Imamura N,Nakayama D,Ishikawa T,Okada M,Orita K,Saito R,Yamauchi N,Sano Y,Kusuhara H,Minami M,Takahashi H,Ikeg

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:To estimate the prevalence and correlates of clinician-diagnosed DSM-IV nonaffective psychosis (NAP) in a national household survey. METHODS:Data came from the United States National Comorbidity Survey Replication (NCS-R). A screen for NAP was followed by blinded sub-sample clinical reappraisal interviews. ...

journal_title：Biological psychiatry

authors： Kessler RC,Birnbaum H,Demler O,Falloon IR,Gagnon E,Guyer M,Howes MJ,Kendler KS,Shi L,Walters E,Wu EQ

更新日期：2005-10-15 00:00:00

abstract：:Male hooded rats were observed for 6 days following implantation with slow-release subcutaneous pellets containing LSD, mescaline, or control vehicle solution. In animals housed in isolation cages, continuous hallucinogen administration resulted in a gradual increase in head twitches and catatonic postures which peake...

journal_title：Biological psychiatry

authors： Ellison G,Ring M,Ross D,Axelrood B

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:Evidence indicates involvement of the endocannabinoid (eCB) system in both the pathophysiology of schizophrenia and working memory (WM) function. Additionally, schizophrenia patients exhibit relatively strong WM deficits. These findings suggest the possibility that the eCB system is also involved in WM defic...

journal_title：Biological psychiatry

authors： Bossong MG,Jansma JM,van Hell HH,Jager G,Oudman E,Saliasi E,Kahn RS,Ramsey NF

更新日期：2012-04-15 00:00:00

abstract：BACKGROUND:Kraepelin originally conceptualized schizophrenia as a degenerative brain disorder. It remains unclear whether the illness is characterized by a static encephalopathy or a deterioration of brain function, or periods of each condition. Assessments of cognitive function, as measured by neuropsychologic assessm...

journal_title：Biological psychiatry

authors： Fucetola R,Seidman LJ,Kremen WS,Faraone SV,Goldstein JM,Tsuang MT

更新日期：2000-07-15 00:00:00

abstract：BACKGROUND:Intracellular deposition of tau protein is a hallmark lesion of Alzheimer's disease. Although it is known this event is secondary to excessive tau phosphorylation, the mechanisms involved remain unknown. We previously reported that the enzyme 5-Lipoxygenase (5LO) acts as a modulator of Aβ peptides formation ...

journal_title：Biological psychiatry

authors： Chu J,Li JG,Ceballos-Diaz C,Golde T,Praticò D

更新日期：2013-09-01 00:00:00

abstract：:Using magnetic resonance imaging (MRI), we measured the volumes of various brain structures and cerebrospinal fluid (CSF) in 19 men with dementia of the Alzheimer type (DAT) and 18 healthy age-matched control men. The mean (+/- S.D) Mini-Mental State exam score (MMSE) of the DAT men was 16 +/- 7; 9 were mildly (MMSE >...

journal_title：Biological psychiatry

authors： Murphy DG,DeCarli CD,Daly E,Gillette JA,McIntosh AR,Haxby JV,Teichberg D,Schapiro MB,Rapoport SI,Horwitz B

更新日期：1993-11-01 00:00:00

abstract：:Eighteen unmedicated patients suffering from major depressive disorder with melancholia (DSM-III) were examined for abnormalities in peripheral serotonin (5-HT) and related metabolites. Serotonin in platelet-free plasma and in platelets from melancholics was significantly reduced to 30% and 60% of their respective con...

journal_title：Biological psychiatry

authors： Sarrias MJ,Artigas F,Martínez E,Gelpí E,Alvarez E,Udina C,Casas M

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Amphetamine administration induces stimulation-independent dopamine release in the nucleus accumbens (NAcc) through reverse dopamine transport, a critical neurochemical event involved in its psychostimulant action, and furthermore decreases stimulation-dependent vesicular dopamine release. These effects may ...

journal_title：Biological psychiatry

authors： David HN,Ansseau M,Lemaire M,Abraini JH

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Fear learning in stressful situations is highly adaptive for survival by steering behavior in subsequent situations, but fear learning can become disproportionate in vulnerable individuals. Despite the potential clinical significance, the mechanism by which stress modulates fear learning is poorly understood...

journal_title：Biological psychiatry

authors： Vogel S,Klumpers F,Kroes MC,Oplaat KT,Krugers HJ,Oitzl MS,Joëls M,Fernández G

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Transcranial magnetic stimulation is a novel, experimental procedure in the treatment of psychiatric disorders, most notably mood disorders. Transcranial magnetic stimulation is currently being widely studied in other applications, and its efficacies and potential side effects are being investigated. METHOD...

journal_title：Biological psychiatry

authors： Dolberg OT,Schreiber S,Grunhaus L

更新日期：2001-03-01 00:00:00

abstract：:Specific electroencephalogram (EEG) changes during clozapine therapy were prospectively studied in a cohort of 50 chronic state hospital patients with schizophrenia who were randomly assigned to one of three nonoverlapping clozapine serum level ranges (50-150 ng/mL, 200-300 ng/mL, and 350-450 ng/mL). EEGs were obtaine...

journal_title：Biological psychiatry

authors： Freudenreich O,Weiner RD,McEvoy JP

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Why do we jump the gun or speak out of turn? Waiting impulsivity has a preclinical basis as a predictor for the development of addiction. Here, we mapped the intrinsic neural correlates of waiting and dissociated it from stopping, both fundamental mechanisms of behavioral control. METHODS:We used a recently...

journal_title：Biological psychiatry

authors： Morris LS,Kundu P,Baek K,Irvine MA,Mechelmans DJ,Wood J,Harrison NA,Robbins TW,Bullmore ET,Voon V

更新日期：2016-03-15 00:00:00

abstract：:Direct current potentials measured on the scalp suprajacent to the midline prefrontal cortex appear to monitor the metabolic activity, via CO2 production, of this portion of the cerebrum. Changes in the frontal potential 90 min after oral administration of 2.0 g L-tryptophan and of 50 mg cortisol were studied in group...

journal_title：Biological psychiatry

authors： Cowen MA

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:Loss of motivation is a characteristic feature of several psychiatric and neurological disorders. However, the neural mechanisms underlying human motivation are far from being understood. Here, we investigate the role that the frontopolar cortex (FPC) plays in motivating cognitive and physical effort exertio...

journal_title：Biological psychiatry

authors： Soutschek A,Kang P,Ruff CC,Hare TA,Tobler PN

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:We previously reported that a single injection of ketamine prior to stress protects against the onset of depressive-like behavior and attenuates learned fear. However, the molecular pathways and brain circuits underlying ketamine-induced stress resilience are still largely unknown. METHODS:Here, we tested w...

journal_title：Biological psychiatry

authors： Mastrodonato A,Martinez R,Pavlova IP,LaGamma CT,Brachman RA,Robison AJ,Denny CA

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Conflicting findings have emerged from studies examining the impact of depression on death and readmission following a coronary event, possibly reflecting differences in the measurement of "depression" and the onset of depression in relation to the coronary event. The aim of this study was to examine the rel...

journal_title：Biological psychiatry

authors： Parker GB,Hilton TM,Walsh WF,Owen CA,Heruc GA,Olley A,Brotchie H,Hadzi-Pavlovic D

更新日期：2008-10-15 00:00:00

abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) and tic disorders have phenomenological and familial-genetic overlaps. An OCD family study sample that excludes Tourette's syndrome in probands is used to examine whether tic disorders are part of the familial phenotype of OCD. METHODS:Eighty case and 73 control probands ...

journal_title：Biological psychiatry

authors： Grados MA,Riddle MA,Samuels JF,Liang KY,Hoehn-Saric R,Bienvenu OJ,Walkup JT,Song D,Nestadt G

更新日期：2001-10-15 00:00:00

abstract：BACKGROUND:Regional brain perfusion in patients during alcohol-withdrawal has been relatively less studied with brain SPECT technique. In this study, the hypothesis that possible regional cerebral blood flow (rCBF) alterations due to alcohol withdrawal might be transitory in a homogenous group of alcoholic patients in ...

journal_title：Biological psychiatry

authors： Tutus A,Kuğu N,Sofuoğlu S,Nardali M,Simşek A,Karaaslan F,Gönül AS

更新日期：1998-06-15 00:00:00

abstract：BACKGROUND:Patients with bipolar disorder have been reported to have abnormal cortical function during mania. In this study, we sought to investigate neural activity in the frontal lobe during mania, using functional magnetic resonance imaging (fMRI). Specifically, we sought to evaluate activation in the lateral orbito...

journal_title：Biological psychiatry

authors： Altshuler LL,Bookheimer SY,Townsend J,Proenza MA,Eisenberger N,Sabb F,Mintz J,Cohen MS

更新日期：2005-11-15 00:00:00

abstract：BACKGROUND:Emerging evidence suggests disruptions in the wiring organization of the brain's network in schizophrenia (SZ) and bipolar disorder (BD). As the importance of genetic predisposition has been firmly established in these illnesses, children (offspring) of patients constitute an at-risk population. This study e...

journal_title：Biological psychiatry

authors： Collin G,Scholtens LH,Kahn RS,Hillegers MHJ,van den Heuvel MP

更新日期：2017-11-15 00:00:00

abstract：BACKGROUND:The relationship between vitamin status and cognitive functioning has been addressed in several recent studies with inconclusive results. The purpose of this study was to examine separate and combined effects of serum vitamin B12 and folic acid on episodic memory functioning in very old age. METHODS:Four st...

journal_title：Biological psychiatry

authors： Hassing L,Wahlin A,Winblad B,Bäckman L

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation (DBS) is an effective treatment for patients with obsessive-compulsive disorder (OCD) that do not respond to conventional therapies. Although the precise mechanism of action of DBS remains unknown, modulation of activity in corticofugal fibers originating in the prefrontal cortex is th...

journal_title：Biological psychiatry

authors： Pinhal CM,van den Boom BJG,Santana-Kragelund F,Fellinger L,Bech P,Hamelink R,Feng G,Willuhn I,Feenstra MGP,Denys D

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:A study was performed to analyze time-of-day variations of different indicators of attention and their interrelations. METHODS:After a sufficiently long all-night sleep 12 healthy non-sleep-deprived subjects ran through a test battery (Stanford Sleepiness Scale, Visual Analogue Scale, Critical Flicker Fusio...

journal_title：Biological psychiatry

authors： Kraemer S,Danker-Hopfe H,Dorn H,Schmidt A,Ehlert I,Herrmann WM

更新日期：2000-12-01 00:00:00

abstract：:Previous studies indicate differences between schizophrenics and normals in thickness and overall size of the corpus callosum, particularly in female subjects. The present study compares the area of the corpus callosum as measured by magnetic resonance imaging (MRI) in men and women experiencing first-episode cases of...

journal_title：Biological psychiatry

authors： Hoff AL,Neal C,Kushner M,DeLisi LE

更新日期：1994-06-15 00:00:00

abstract：:Cannabis use has been reported to increase the risk of developing schizophrenia and to worsen symptoms of the illness. Both of these outcomes might be attributable to the disruption by cannabis of the endogenous cannabinoid system's spatiotemporal regulation of the inhibitory circuitry in the prefrontal cortex that is...

journal_title：Biological psychiatry

authors： Volk DW,Lewis DA

更新日期：2016-04-01 00:00:00

abstract：:Dietary administration of L-tryptophan to rats failed to increase blood platelets. Instead platelet counts were decreased after feeding either a tryptophan-deficient or tryptophan-enriched (10%) diet, but were unchanged in animals on a 1% tryptophan diet. Platelet median volumes were not affected by any of these dieta...

journal_title：Biological psychiatry

authors： Sakuma M

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced so...

journal_title：Biological psychiatry

authors： Swartz JR,Waller R,Bogdan R,Knodt AR,Sabhlok A,Hyde LW,Hariri AR

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the first choice for the pharmacologic treatment of bulimia nervosa, but there are no published data on the putative altered serotonin (5-HT) receptor characteristics in patients with bulimia. Experimental studies suggest that the therapeutic antidepressant...

journal_title：Biological psychiatry

authors： Tiihonen J,Keski-Rahkonen A,Löppönen M,Muhonen M,Kajander J,Allonen T,Någren K,Hietala J,Rissanen A

更新日期：2004-04-15 00:00:00