Abstract:
BACKGROUND:A genetic component has a role in the etiology of Panic Disorder (PD) and a familial association between PD and CO2 hypersensitivity have been repeatedly described. METHODS:Complex segregation analysis was performed on a sample of 165 families of PD probands and on the subgroup homogeneous for CO2 hypersensitivity, using Regressive Logistic Models. The only relatives considered to be affected were those with PD. Relatives have been diagnosed according to Family History Method. RESULTS:A Mendelian hypothesis was compatible with our data, without distinction between different models of transmission. The Akaike's Information Criterion values indicated that the Additive model was the most parsimonious, with a gene frequency of .0005, incomplete penetrance and a phenocopy rate of .00029. By subdividing the families according to the probands' responses to CO2 inhalations, probands of 134 families were hypersensitive to CO2. The analysis performed on this subgroup supported the existence of a SML with a best fit for a Dominant model. CONCLUSIONS:A SML account for genetic transmission in PD families and 35% CO2 challenge test may individuate a genetically homogeneous subgroup of patients with PD.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Cavallini MC,Perna G,Caldirola D,Bellodi Ldoi
10.1016/s0006-3223(99)00004-9subject
Has Abstractpub_date
1999-09-15 00:00:00pages
815-20issue
6eissn
0006-3223issn
1873-2402pii
S0006-3223(99)00004-9journal_volume
46pub_type
杂志文章abstract::The acoustic startle response (ASR) and midlatency auditory evoked potentials (AEP) have been utilized in the measurement of sensory inhibition. Using these different paradigms, abnormalities suggesting a lack of normal inhibition have been noted in a number of psychiatric syndromes. To date, the most commonly used se...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(93)90023-7
更新日期:1993-06-01 00:00:00
abstract::To confirm and extend previous observations concerning the correlation between cell-mediated immunity and psychiatric diseases, 511 patients with schizophrenia, cerebral atrophy, dementia, and mental retardation, and 32 control subjects and 27 control patients were skin-tested with human brain S-100 protein and human ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:Since low serum iron has been reported in a variety of neuropsychiatric motor disorders, this study was conducted to examine serum iron in patients with a catatonic disorder. METHODS:Forty catatonic and 40 noncatatonic psychotic patients were studied in relation to serum iron levels. The association of seru...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(98)00137-1
更新日期:1999-03-15 00:00:00
abstract::To determine the degree of genetic and environmental influences on assessments of aggression and irritability in male subjects, the "Motor Aggression" subscales of the Buss-Durkee Hostility Inventory (BDHI) were mailed to 1208 male twins in the Vietnam Era Twin Registry. Data from monozygotic 182 and 118 dizygotic twi...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/s0006-3223(96)00257-0
更新日期:1997-02-01 00:00:00
abstract::The validity of previously hypothesized predictors of elapse following neuroleptic discontinuation was examined. One hundred sixty-two outpatients, with either Research Diagnostic Criteria schizophrenia or schizoaffective disorder, were discontinued from neuroleptic medication for a 28-day period or until judged to be...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90143-n
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:In a single-center, placebo-controlled study, topiramate reduced binge eating and weight in patients with binge eating disorder (BED) and obesity. The current investigation evaluated the safety and efficacy of topiramate in a multicenter, placebo-controlled trial. METHODS:Eligible patients between 18 and 65...
journal_title:Biological psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.biopsych.2006.08.008
更新日期:2007-05-01 00:00:00
abstract::There is increasing evidence of a deficit or disturbance of neurons in the brains of schizophrenic patients--evidence that particularly implicates the frontal or temporal lobes. As yet there is no direct neurochemical correlate of the transmitter systems involved, although changes in some neurotransmitters in the temp...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(90)90039-5
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:In addition to cognitive impairment, there are disruptions to mood and emotion processing in attention-deficit/hyperactivity disorder (ADHD) but little is known about their neural basis. We examined ADHD disturbances in mood and emotion recognition and underlying neural systems before and after treatment wit...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2007.11.022
更新日期:2008-05-15 00:00:00
abstract:BACKGROUND:Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety- and depressive-like behaviors. Concomitantly, microglia in the PFC undergo morphological and functional changes following stress exposure, suggesting that micro...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2017.05.026
更新日期:2018-01-01 00:00:00
abstract::The dexamethasone suppression test (DST) and sleep EEG were compared in three different descriptive diagnostic schemes in 70 adult patients with nonpsychotic, unipolar major depressive disorder according to Research Diagnostic Criteria. Endogenous (E)/nonendogenous (NE), primary/secondary, and Winokur's family history...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Identifying beneficial surrogate genetic markers in psychiatric disorders is crucial but challenging. METHODS:Given that scalp hair follicles are easily accessible and, like the brain, are derived from the ectoderm, expressions of messenger RNA (mRNA) and microRNA in the organ were examined between schizoph...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2014.07.025
更新日期:2015-07-15 00:00:00
abstract::We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D1 and anti-D2 dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D1, not anti-D2 activity, t...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0006-3223(92)90229-s
更新日期:1992-02-15 00:00:00
abstract::Unlike disorders of other fields of medicine (eg., diabetes, heart disease), schizophrenia has been only marginally impacted by the study of animal models. This gap reflects the incomplete understanding of the causes and mechanisms of schizophrenia and the resulting lack of defined targets for model development. Howev...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(01)01286-0
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Increased dopaminergic activity may play a primary role in psychotic depression. Dopamine beta-hydroxylase (DbetaH) catalyses the key step in biosynthesis of the neurotransmitter noradrenaline from dopamine, and low DbetaH activity is a possible risk factor for developing psychotic depression. An exon 2 poly...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(01)01367-1
更新日期:2002-03-01 00:00:00
abstract::The benzodiazepines are generally safe and effective drugs with usually only minor side effects, dose-related sedation being the most common. A range of paradoxical effects can occur of which release of aggressive and hostile feelings has excited most attention. These responses are idiosyncratic however, as most patie...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:Numerous studies have implicated neurogenesis in the hippocampus in animal models of depression, especially those related to controllability and learned helplessness. Here, we tested the hypothesis that uncontrollable but not controllable stress would reduce cell proliferation in the hippocampus of male and ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.10.033
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Oculomotor tasks are a well-established means of studying executive functions and frontal-striatal functioning in both nonhuman primates and humans. Attention-deficit/hyperactivity disorder (ADHD) is thought to implicate frontal-striatal circuitry. We used oculomotor tests to investigate executive functions ...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/j.biopsych.2005.02.029
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Ventral tegmental area (VTA) brain-derived neurotrophic factor (BDNF) contributes to time-dependent increases in cue-induced cocaine seeking after withdrawal (incubation of cocaine craving). Here, we studied the role of glial cell line-derived neurotrophic factor (GDNF) in incubation of cocaine craving becau...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.02.009
更新日期:2009-07-15 00:00:00
abstract:BACKGROUND:The hippocampus (HC) is smaller in patients with recurrent major depressive disorder (MDD), but few longitudinal studies have examined whether volume is associated with clinically meaningful outcomes such as response to treatment. METHODS:We compared regional (head and body/tail) HC volumes in 46 patients w...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.06.027
更新日期:2008-11-15 00:00:00
abstract::The specific binding of (3H)kainic acid (KA) to high- and low-affinity receptor sites was assayed in postmortem samples from the brains of patients affected with Huntington's disease (HD) and age-matched controls. Treatment of rat brain with conditions that closely mimic the temperature gradient occurring in postmorte...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, so it was expected that posttraumatic stress disorder (PTSD) would be associated with activation of this axis; however, studies have found both increased and decreased cortisol in PTSD. To address this question, we collected saliva cortisol at h...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.05.011
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Cannabis remains the most widely used illicit substance by adolescents and is typically consumed by this population in the context of ongoing tobacco use. Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects o...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.02.014
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects indu...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2015.08.013
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Whether paternal age effect on schizophrenia is a causation or just an association due to confounding by selection into late parenthood is still debated. We investigated the association between paternal age and early onset of schizophrenia in offspring, controlling for both paternal and maternal predispositi...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.01.023
更新日期:2019-07-01 00:00:00
abstract::This report describes a series of experiments, all of which demonstrate a strong contribution of the behavioral pattern manifested at the time of initial amphetamine injection to the topography and development of the stereotypy that develops with chronic amphetamine intoxication. These initial behavioral patterns refl...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1975-02-01 00:00:00
abstract::Serum samples from 307 patients with various chronic mental disorders were examined for the presence of several autoantibodies. Autoantibodies detected included antinuclear antibodies (ANA) in 122/307 (39.7%), rheumatoid factor (RF) in 23/307 (7.5%), anticardiolipin antibodies (anti-CL) in 23/304 (7.6%, IgM in 12 pati...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(90)90590-x
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Abnormalities of cortical neuronal organization and reductions in neuronal somal size have been reported in schizophrenia. The purpose of this investigation was to assess patterns of neuronal and glial distribution in the anterior cingulate cortex (ACC) in major depressive disorder (MDD), schizophrenia, bipo...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(03)00114-8
更新日期:2003-06-15 00:00:00
abstract:BACKGROUND:The endocannabinoid and neurosteroid systems regulate emotions and stress responses. Activation of peroxisome proliferator-activated receptor (PPAR)-α by the endocannabinoid congener N-palmitoylethanolamine (PEA) regulates pathophysiological systems (e.g., inflammation, oxidative stress) and induces peripher...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.02.006
更新日期:2019-06-15 00:00:00
abstract::A group of 29 bipolar manic-depressives completed a 12-month double-blind cross-over trial of low-dose and high-dose lithium prophylaxis. Twelve patients relapsed, and significantly more of the relapses occurred during the low-dose 6-month phase of the trial. There was a trend for relapse to occur within 2 months of a...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-11-01 00:00:00
abstract::Urinary MHPG concentrations and platelet 3H-imipramine binding (Bmax, Kd) were measured in 20 psychiatric inpatients with diagnoses of major depressive disorder. Clinical assessments were performed using the Present State Examination (PSE) interview, and several dimensions of symptomatology were constructed on the bas...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(88)90003-0
更新日期:1988-03-15 00:00:00