Abstract:
BACKGROUND:Identifying beneficial surrogate genetic markers in psychiatric disorders is crucial but challenging. METHODS:Given that scalp hair follicles are easily accessible and, like the brain, are derived from the ectoderm, expressions of messenger RNA (mRNA) and microRNA in the organ were examined between schizophrenia (n for first/second = 52/42) and control subjects (n = 62/55) in two sets of cohort. Genes of significance were also analyzed using postmortem brains (n for case/control = 35/35 in Brodmann area 46, 20/20 in cornu ammonis 1) and induced pluripotent stem cells (n = 4/4) and pluripotent stem cell-derived neurospheres (n = 12/12) to see their role in the central nervous system. Expression levels of mRNA for autism (n for case/control = 18/24) were also examined using scalp hair follicles. RESULTS:Among mRNA examined, FABP4 was downregulated in schizophrenia subjects by two independent sample sets. Receiver operating characteristic curve analysis determined that the sensitivity and specificity were 71.8% and 66.7%, respectively. FABP4 was expressed from the stage of neurosphere. Additionally, microarray-based microRNA analysis showed a trend of increased expression of hsa-miR-4449 (p = .0634) in hair follicles from schizophrenia. hsa-miR-4449 expression was increased in Brodmann area 46 from schizophrenia (p = .0007). Finally, we tested the expression of nine putative autism candidate genes in hair follicles and found decreased CNTNAP2 expression in the autism cohort. CONCLUSIONS:Scalp hair follicles could be a beneficial genetic biomarker resource for brain diseases, and further studies of FABP4 are merited in schizophrenia pathogenesis.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Maekawa M,Yamada K,Toyoshima M,Ohnishi T,Iwayama Y,Shimamoto C,Toyota T,Nozaki Y,Balan S,Matsuzaki H,Iwata Y,Suzuki K,Miyashita M,Kikuchi M,Kato M,Okada Y,Akamatsu W,Mori N,Owada Y,Itokawa M,Okano H,Yoshikawa Tdoi
10.1016/j.biopsych.2014.07.025subject
Has Abstractpub_date
2015-07-15 00:00:00pages
116-25issue
2eissn
0006-3223issn
1873-2402pii
S0006-3223(14)00570-8journal_volume
78pub_type
杂志文章abstract:BACKGROUND:The endocannabinoid and neurosteroid systems regulate emotions and stress responses. Activation of peroxisome proliferator-activated receptor (PPAR)-α by the endocannabinoid congener N-palmitoylethanolamine (PEA) regulates pathophysiological systems (e.g., inflammation, oxidative stress) and induces peripher...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.02.006
更新日期:2019-06-15 00:00:00
abstract::Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis, demonstrated by failure to suppress cortisol secretion after dexamethasone, is found in approximately 50% of patients with major depression (MD). In this study, we examined the response of adrenocorticotrophic hormone (ACTH) and cortisol to insulin-induced ...
journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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doi:
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pub_type: 杂志文章,评审
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更新日期:2001-10-01 00:00:00
abstract::Sleep and 24-hr body core temperature were measured during a 2- to 3-week study interval in 15 endogenous depressives, 12 patients after remission, and 10 normal control subjects. The total sample was subdivided into one group of persons who displayed at least one sleep onset REM episode (SOREM; latency less than or e...
journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1983-12-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2015-10-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1985-10-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,meta分析
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更新日期:2019-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,meta分析
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更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.07.032
更新日期:2020-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:1991-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(98)00138-3
更新日期:1998-07-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(89)90215-1
更新日期:1989-03-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2015.08.013
更新日期:2016-03-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2010.09.053
更新日期:2011-05-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(94)91237-8
更新日期:1994-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2021-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2006-09-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2013.10.027
更新日期:2014-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2000-09-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2011.02.019
更新日期:2011-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2017.11.035
更新日期:2018-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1980-02-01 00:00:00
abstract::Urinary MHPG concentrations and platelet 3H-imipramine binding (Bmax, Kd) were measured in 20 psychiatric inpatients with diagnoses of major depressive disorder. Clinical assessments were performed using the Present State Examination (PSE) interview, and several dimensions of symptomatology were constructed on the bas...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(88)90003-0
更新日期:1988-03-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/S0006-3223(96)00297-1
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Monoamine oxidase (MAO) is a critical enzyme in deamination of biogenic amines and may be involved in the pathophysiology of major psychosis, including mood disorder and schizophrenia. Recently, evidence for genetic association between the MAO-A gene and bipolar mood disorder was obtained in Caucasians. MET...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(97)00522-2
更新日期:1998-11-01 00:00:00