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Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging.

Abstract：

:A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

O'Sullivan RL,Rauch SL,Breiter HC,Grachev ID,Baer L,Kennedy DN,Keuthen NJ,Savage CR,Manzo PA,Caviness VS,Jenike MA

doi

10.1016/S0006-3223(96)00297-1

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

39-45

issue

1

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(96)00297-1

journal_volume

42

pub_type

杂志文章

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