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Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings.

Abstract：

BACKGROUND:Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). METHODS:A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. RESULTS:A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. CONCLUSIONS:These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Zhou K,Asherson P,Sham P,Franke B,Anney RJ,Buitelaar J,Ebstein R,Gill M,Brookes K,Buschgens C,Campbell D,Chen W,Christiansen H,Fliers E,Gabriëls I,Johansson L,Marco R,Mulas F,Müller U,Mulligan A,Neale BM,Rijsdij

doi

10.1016/j.biopsych.2008.02.024

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

571-6

issue

7

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(08)00337-5

journal_volume

64

pub_type

杂志文章

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