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Excitation-inhibition discoordination in rodent models of mental disorders.

Abstract：

:Animal models of mental illness provide a foundation for evaluating hypotheses for the mechanistic causes of mental illness. Neurophysiological investigations of neural network activity in rodent models of mental dysfunction are reviewed from the conceptual framework of the discoordination hypothesis, which asserts that failures of neural coordination cause cognitive deficits in the judicious processing and use of information. Abnormal dynamic coordination of excitatory and inhibitory neural discharge in pharmacologic and genetic rodent models supports the discoordination hypothesis. These observations suggest excitation-inhibition discoordination and aberrant neural circuit dynamics as causes of cognitive impairment, as well as therapeutic targets for cognition-promoting treatments.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Fenton AA

doi

10.1016/j.biopsych.2015.03.013

subject

Has Abstract

pub_date

2015-06-15 00:00:00

pages

1079-88

issue

12

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(15)00227-9

journal_volume

77

pub_type

杂志文章,评审

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