Abstract：
BACKGROUND:Using diffusion tensor imaging (DTI), we previously reported abnormalities in two critical white matter tracts in schizophrenia, the uncinate fasciculus (UF) and the cingulum bundle (CB), both related to fronto-temporal connectivity. Here, we investigate these two bundles in unmedicated subjects with schizotypal personality disorder (SPD). METHODS:Fifteen male SPD subjects and 15 male control subjects were scanned with line-scan DTI. Fractional anisotropy (FA) and mean diffusivity (D(m)) were used to quantify water diffusion, and cross-sectional area was defined with a directional threshold method. Exploratory correlation analyses were evaluated with Spearman's rho, followed by post hoc hierarchical regression analyses. RESULTS:We found bilaterally reduced FA in the UF of SPD subjects. For CB, there was no significant group difference for FA or D(m) measures. Additionally, in SPD, reduced FA in the right UF was correlated with clinical symptoms, including ideas of reference, suspiciousness, restricted affect, and social anxiety. In contrast, left UF area was correlated with measures of cognitive function, including general intelligence, verbal and visual memory, and executive performance. CONCLUSIONS:These findings in SPD suggest altered fronto-temporal connectivity through the UF, similar to findings in schizophrenia, and intact neocortical-limbic connectivity through the CB, in marked contrast with what has been reported in schizophrenia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Nakamura M,McCarley RW,Kubicki M,Dickey CC,Niznikiewicz MA,Voglmaier MM,Seidman LJ,Maier SE,Westin CF,Kikinis R,Shenton MEdoi
10.1016/j.biopsych.2005.04.016subject
Has Abstractpub_date
2005-09-15 00:00:00pages
468-78issue
6eissn
0006-3223issn
1873-2402pii
S0006-3223(05)00471-3journal_volume
58pub_type
杂志文章abstract：BACKGROUND:Preclinical studies demonstrate that 17beta-estradiol (E(2)) increases serotonin-2A receptor (5-HT(2A)R) density in rat frontal cortex. METHODS:We investigated the impact of hormone replacement therapy on 5-HT(2A)R binding potential (BP) using positron emission tomography and [(18)F]altanserin in five postm...
journal_title：Biological psychiatry
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abstract：BACKGROUND:Although neuropsychological and neuroimaging studies of obsessive-compulsive disorder (OCD) have implicated the frontal cortex and subcortical structures in the pathophysiology of the disorder, few studies have examined cognitive function in patients with OCD on tasks validated in the assessment of frontal l...
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abstract：BACKGROUND:We previously reported that a single injection of ketamine prior to stress protects against the onset of depressive-like behavior and attenuates learned fear. However, the molecular pathways and brain circuits underlying ketamine-induced stress resilience are still largely unknown. METHODS:Here, we tested w...
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abstract：BACKGROUND:Plasma cortisol, beta-endorphin, corticotropin, corticotropin-releasing factor, and salivary cortisol concentrations, resting and after ingestion of 1 mg of dexamethasone, were investigated in depressed patients and controls. METHODS:Fourteen outpatients from the psychiatric department diagnosed with depres...
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journal_title：Biological psychiatry
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pub_type： 临床试验,杂志文章,随机对照试验
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doi：
更新日期：1982-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.06.030
更新日期：2006-01-15 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2011-11-15 00:00:00
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更新日期：2017-03-01 00:00:00
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更新日期：2005-11-01 00:00:00
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更新日期：2016-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
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