Abstract：
BACKGROUND:A large number of studies suggest the presence of deficits in dorsolateral prefrontal cortex function during performance of working memory tasks in individuals with schizophrenia. However, working memory deficits may also present in other psychiatric disorders, such as major depression. It is not clear whether people with major depression also demonstrate impaired prefrontal activation during performance of working memory tasks. METHODS:We used functional magnetic resonance imaging to assess the patterns of cortical activation associated with the performance of a 2-back version of the N-Back task (working memory) in 38 individuals with schizophrenia and 14 with major depression. RESULTS:We found significant group differences in the activation of dorsolateral prefrontal cortex associated with working memory performance. Consistent with prior research, participants with schizophrenia failed to show activation of right dorsolateral prefrontal cortex in response to working memory tasks demands, whereas those with major depression showed clear activation of right and left dorsolateral prefrontal cortex as well as bilateral activation of inferior and superior frontal cortex. CONCLUSIONS:During performance of working memory tasks, deficits in prefrontal activation, including dorsolateral regions, are more severe in participants with schizophrenia (most of whom were recently released outpatients) than in unmedicated outpatients with acute nonpsychotic major depression.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Barch DM,Sheline YI,Csernansky JG,Snyder AZdoi
10.1016/s0006-3223(02)01674-8subject
Has Abstractpub_date
2003-03-01 00:00:00pages
376-84issue
5eissn
0006-3223issn
1873-2402pii
S0006322302016748journal_volume
53pub_type
杂志文章abstract：:The authors evaluated magnetic resonance imaging (MRI) of deep white matter hyperintensity (DWMH) in 90 adult psychiatric inpatients in whom MRIs were clinically indicated and 25 age-matched, medically healthy controls. Forty-two percent of the psychiatric patients and 12% of the controls had evidence of DWMH on MRI. ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90058-t
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND:The neurofibromatosis type 1 (Nf1) gene encodes a GTPase activating protein that negatively regulates small GTPases of the Ras family. METHODS:We assessed alcohol-related behaviors including alcohol sensitivity, dependent and nondependent drinking, and basal and alcohol-induced gamma-aminobutyric acid (GABA...
journal_title：Biological psychiatry
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doi：10.1016/j.biopsych.2014.07.031
更新日期：2015-05-15 00:00:00
abstract：:Serotonin (5-HT) has been implicated in the control of eating behavior and body weight. Stimulants of this monoamine reduce food intake and weight gain and increase energy expenditure, both in animals and in humans. This article reviews evidence that supports a role for hypothalamic serotonergic receptor mechanisms in...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(98)00186-3
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:Impulsive aggression in patients with personality disorders is associated with diminished levels of cerebrospinal fluid (CSF) 5-HIAA, blunted neuroendocrine responses to serotonergic agonists, and decreased glucose utilization in the prefrontal cortex. We tested the hypothesis that impulsive aggression in bo...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(99)00202-4
更新日期：2000-03-15 00:00:00
abstract：:Federal regulations governing human subjects research call for additional protections for the "mentally disabled." However, there is currently no consensus definition of mental disability or guidelines for how these research subjects should be protected. This ambiguity complicates the work of institutional review boar...
journal_title：Biological psychiatry
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doi：10.1016/s0006-3223(99)00168-7
更新日期：1999-10-15 00:00:00
abstract：:The effects of thyrotropin-releasing hormone (TRH) administration on electroconvulsive therapy (ECT)-induced prolactin (PRL) secretion and the duration of the seizure were studied in 14 depressed women. In a balanced order crossover design the patients were given 0.4 mg TRH or placebo intravenously 20 min before ECT d...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1996-03-15 00:00:00
abstract：:[3H]imipramine binding to platelets was measured in 17 drug-free panic disorder patients and 14 healthy controls. No difference in Bmax or Kd values was found between the two groups. Patients with a past history of major melancholic depression or severe agoraphobia had similar binding parameters as panic disorder pati...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90129-6
更新日期：1987-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)00238-X
更新日期：1995-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90215-1
更新日期：1989-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(95)00078-X
更新日期：1996-02-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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更新日期：1990-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0006-3223(89)90037-1
更新日期：1989-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.04.023
更新日期：2007-10-15 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(99)00088-8
更新日期：1999-08-01 00:00:00
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doi：10.1016/0006-3223(90)90420-7
更新日期：1990-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.09.036
更新日期：2009-04-15 00:00:00
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更新日期：2017-03-01 00:00:00
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更新日期：1992-04-15 00:00:00
abstract：:This article has been retracted, consistent with Elsevier Policy on Article Withdrawal. Please see . The Publisher apologises for any inconvenience this may cause. ...
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doi：10.1016/j.biopsych.2005.10.027
更新日期：2006-02-14 00:00:00
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更新日期：2010-06-01 00:00:00
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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更新日期：1990-05-15 00:00:00
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doi：
更新日期：1983-05-01 00:00:00
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journal_title：Biological psychiatry
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更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Among the diverse animal models proposed for schizophrenia, the neonatal ventral hippocampal lesion (NVHL) is one of the most widely used. However, its construct validity can be questioned because there is no evidence of a lesion present in schizophrenia. Other approaches that have tried to capture environme...
journal_title：Biological psychiatry
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更新日期：2010-02-15 00:00:00
abstract：BACKGROUND:Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder. METHODS:We studied a rare cohort consisting of 98 probands; 71 of these probands receiv...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.01.024
更新日期：2004-05-15 00:00:00
