Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer's disease.

abstract：BACKGROUND:The aim of this study was to extend our previous work on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) in major depression to patients with schizophrenia. METHODS:Thirty-five inpatients with schizophrenia were randomly assigned to either right prefrontal rTMS or sham treatm...

journal_title：Biological psychiatry

authors： Klein E,Kolsky Y,Puyerovsky M,Koren D,Chistyakov A,Feinsod M

更新日期：1999-11-15 00:00:00

abstract：:The intuitive association between self-focused rumination in major depressive disorder (MDD) and the self-referential operations performed by the brain's default-mode network (DMN) has prompted interest in examining the role of the DMN in MDD. In this article, we present meta-analytic findings showing reliably increas...

journal_title：Biological psychiatry

authors： Hamilton JP,Farmer M,Fogelman P,Gotlib IH

更新日期：2015-08-15 00:00:00

abstract：BACKGROUND:Schizophrenia is associated with impaired antioxidant defense, including abnormal serum, plasma, and red blood cell (RBC) oxidative stress parameters. We performed a meta-analysis of these associations, considering the effect of clinical status and antipsychotic treatment after an acute exacerbation of psych...

journal_title：Biological psychiatry

authors： Flatow J,Buckley P,Miller BJ

更新日期：2013-09-15 00:00:00

abstract：BACKGROUND:The stomach-derived hormone ghrelin drives higher-order feeding processes related to food reward and food seeking via central nervous system signaling at its receptor (GHSR1A). The specific nuclei mediating these effects are only partially understood. Here, we use a rat model to examine whether ghrelin signa...

journal_title：Biological psychiatry

authors： Kanoski SE,Fortin SM,Ricks KM,Grill HJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Recent research suggests that immune dysregulation in pregnancy could be a risk factor for anxiety and depression symptoms in offspring. Whereas animal studies have demonstrated the importance of the link between perinatal cytokines and abnormal behaviors in offspring, human epidemiological studies in this a...

journal_title：Biological psychiatry

authors： Galera C,Barbosa S,Collet O,Khalfallah O,Aouizerate B,Sutter-Dalley AL,Koehl M,Capuron L,Van der Waerden J,Melchior M,Côté S,Heude B,Glaichenhaus N,Davidovic L,EDEN Mother–Child Cohort Study Group.

更新日期：2020-10-24 00:00:00

abstract：:This review describes the strategy of using elementary phenotypes for neurobiological and genetic linkage studies of schizophrenia. The review concentrates on practical aspects of selecting the phenotype and then understanding the confounds in its measurement and interpretation. Examples from the authors' studies of d...

journal_title：Biological psychiatry

authors： Adler LE,Freedman R,Ross RG,Olincy A,Waldo MC

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Volatile interpersonal relationships are a core feature of borderline personality disorder (BPD) and lead to devastating disruption of patients' personal and professional lives. Quantitative models of social decision making and learning hold promise for defining the underlying mechanisms of this problem. In ...

journal_title：Biological psychiatry

authors： Fineberg SK,Leavitt J,Stahl DS,Kronemer S,Landry CD,Alexander-Bloch A,Hunt LT,Corlett PR

更新日期：2018-12-01 00:00:00

abstract：:Tricyclic antidepressants are thought to act primarily via effects on adrenergic neurotransmitters. Recent research supports the concept that a major function of the central adrenergic system is the modulation of cerebral fluid dynamics. Based on this concept, studies in the rat were conducted to assess the effects of...

journal_title：Biological psychiatry

authors： Preskorn SH,Hartman BK

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Sleep disturbance is associated with activation of systemic and cellular inflammation, as well as proinflammatory transcriptional profiles in circulating leukocytes. Whether treatments that target insomnia-related complaints might reverse these markers of inflammation in older adults with insomnia is not kno...

journal_title：Biological psychiatry

authors： Irwin MR,Olmstead R,Breen EC,Witarama T,Carrillo C,Sadeghi N,Arevalo JM,Ma J,Nicassio P,Bootzin R,Cole S

更新日期：2015-11-15 00:00:00

abstract：:We examined the association between post-dexamethasone suppression test (DST) serum cortisol and body weight, self-report of weight loss during the episode, and measured weight loss during the first week of admission in a series of 245 depressed inpatients. Data on measured weight loss between two successive admission...

journal_title：Biological psychiatry

authors： Pfohl B,Coryell W,Stangl D,Zimmerman M

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Several studies have reported elevated S100B serum levels in schizophrenia. Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE). Given the benefits of sRAGE in metabolic and inflammatory diseases, we hypothesized a similar effect in schizophrenia. METHODS:S100B a...

journal_title：Biological psychiatry

authors： Steiner J,Walter M,Wunderlich MT,Bernstein HG,Panteli B,Brauner M,Jacobs R,Gos T,Rothermundt M,Bogerts B

更新日期：2009-06-15 00:00:00

abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder without validated objective markers. Eye movement studies may be useful in providing objective criteria for characterizing the disorder. METHODS:We compared 53 children (29 girls) with ADHD to 44 healthy control children (18 gi...

journal_title：Biological psychiatry

authors： Gould TD,Bastain TM,Israel ME,Hommer DW,Castellanos FX

更新日期：2001-10-15 00:00:00

abstract：BACKGROUND:Down syndrome (DS) is a genetic disorder (trisomy 21 in 96% of cases), associated with an excess of a key enzyme involved with free radical metabolism (FRM), superoxide dismutase-1 (SOD-1), that is encoded by a gene on chromosome 21. Consequently, SOD-1 activity is elevated in DS, which also occurs in condit...

journal_title：Biological psychiatry

authors： Brugge K,Nichols S,Saitoh T,Trauner D

更新日期：1999-12-15 00:00:00

abstract：:Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma rat...

journal_title：Biological psychiatry

authors： Branchey L,Branchey M,Worner TM,Zucker D,Shaw S,Lieber CS

更新日期：1985-11-01 00:00:00

abstract：:We compared the EEG-monitored sleep of 8 women with anorexia nervosa and 16 normal weight women with bulimia to that of 14 normal women. The patients with anorexia nervosa spent less time asleep and spent less of their sleep time in Stage 1. The sleep of the normal weight patients with bulimia was remarkably similar t...

journal_title：Biological psychiatry

authors： Walsh BT,Goetz R,Roose SP,Fingeroth S,Glassman AH

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:The cardiovascular safety of mixed amphetamine salts extended release (MAS XR) was evaluated in 2968 children 6-12 years of age with attention-deficit/hyperactivity disorder (ADHD). METHODS:In this prospective, open-label, noncomparative, community-based study, subjects whose symptoms of ADHD were well cont...

journal_title：Biological psychiatry

authors： Donner R,Michaels MA,Ambrosini PJ

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation (DBS) is an effective treatment for patients with obsessive-compulsive disorder (OCD) that do not respond to conventional therapies. Although the precise mechanism of action of DBS remains unknown, modulation of activity in corticofugal fibers originating in the prefrontal cortex is th...

journal_title：Biological psychiatry

authors： Pinhal CM,van den Boom BJG,Santana-Kragelund F,Fellinger L,Bech P,Hamelink R,Feng G,Willuhn I,Feenstra MGP,Denys D

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:Psychostimulants and opiates trigger similar enduring neuroadaptations within the reward circuitry thought to underlie addiction. Transcription factors are key to mediating these enduring behavioral alterations. The facilitation of these maladaptive changes by glucocorticoid hormones suggests that the glucoc...

journal_title：Biological psychiatry

authors： Barik J,Parnaudeau S,Saint Amaux AL,Guiard BP,Golib Dzib JF,Bocquet O,Bailly A,Benecke A,Tronche F

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Animal and human studies implicate forebrain neural circuits in maternal behavior. Here, we hypothesized that human brain response to emotional stimuli relevant for social interactions between infants and adults are modulated by sex- and experience-dependent factors. METHODS:We used functional magnetic reso...

journal_title：Biological psychiatry

authors： Seifritz E,Esposito F,Neuhoff JG,Lüthi A,Mustovic H,Dammann G,von Bardeleben U,Radue EW,Cirillo S,Tedeschi G,Di Salle F

更新日期：2003-12-15 00:00:00

abstract：BACKGROUND:Excessive glutamatergic neurotransmission may contribute to the pathophysiology of major depressive disorder (MDD). Recent evidence suggests that riluzole and other agents that target glutamate neurotransmission may show antidepressant activity. METHODS:Ten patients with treatment-resistant depression had r...

journal_title：Biological psychiatry

authors： Sanacora G,Kendell SF,Levin Y,Simen AA,Fenton LR,Coric V,Krystal JH

更新日期：2007-03-15 00:00:00

abstract：:Athina Markou and others argue forcefully for the adoption of a "translational-back translational strategy" for central nervous system drug discovery involving novel application of drugs with established safety profiles in proof-of-principle studies in humans, which in turn encourage parallel studies using experimenta...

journal_title：Biological psychiatry

authors： Phillips AG,Geyer MA,Robbins TW

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:The amplitude of the auditory P3 event-related potential is reduced in patients with axes I and II disorders. Data regarding P3 amplitude and normal personality traits in healthy individuals have been inconsistent, however, although more extreme variants of dimensional traits such as neuroticism and extraver...

journal_title：Biological psychiatry

authors： Gurrera RJ,O'Donnell BF,Nestor PG,Gainski J,McCarley RW

更新日期：2001-06-01 00:00:00

abstract：:The specific binding to platelet membranes (Bmax) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment Bmax for 3H-clonidine showed a sign...

journal_title：Biological psychiatry

authors： Rosen J,Silk KR,Rice HE,Smith CB

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Head growth rates are often accelerated in autism. This study is aimed at defining the clinical, morphological, and biochemical correlates of head circumference in autistic patients. METHODS:Fronto-occipital head circumference was measured in 241 nonsyndromic autistic patients, 3 to 16 years old, diagnosed ...

journal_title：Biological psychiatry

authors： Sacco R,Militerni R,Frolli A,Bravaccio C,Gritti A,Elia M,Curatolo P,Manzi B,Trillo S,Lenti C,Saccani M,Schneider C,Melmed R,Reichelt KL,Pascucci T,Puglisi-Allegra S,Persico AM

更新日期：2007-11-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) measures of dynorphin A were compared in three groups. Alzheimer patients (n = 9), elderly depressives (n = 9), and age-matched normal controls (n = 9). The Alzheimer patients revealed a 40% decrease in CSF dynorphin compared with controls (36 +/- 15 versus 60 +/- 21 pg/ml, p less than 0.05)....

journal_title：Biological psychiatry

authors： Sunderland T,Berrettini WH,Molchan SE,Lawlor BA,Martinez RA,Vitiello B,Tariot PN,Cohen RM

更新日期：1991-07-01 00:00:00

abstract：:Concentrations of the three main monoamines (5-HT, NA, and DA), their metabolites (5-HIAA, DOPAC, and HVA), and the serotonin precursor 5-hydroxy-L-tryptophan were simultaneously measured in frontal cortex, gyrus cinguli, and hypothalamus from 23 controls and 18 suicide victims. Overall suicides did not show significa...

journal_title：Biological psychiatry

authors： Arranz B,Blennow K,Eriksson A,Månsson JE,Marcusson J

更新日期：1997-05-15 00:00:00

abstract：BACKGROUND:Identifying the underlying cellular mechanisms of episodic memory is an important challenge, since this memory, based on temporal and contextual associations among events, undergoes preferential degradation in aging and various neuropsychiatric disorders. Memory storage of temporal and contextual association...

journal_title：Biological psychiatry

authors： Potier M,Georges F,Brayda-Bruno L,Ladépêche L,Lamothe V,Al Abed AS,Groc L,Marighetto A

更新日期：2016-05-01 00:00:00

abstract：:Over the past 30 years, investigators have used nonlinear and so-called chaos theory-based techniques to examine a wide range of phenomena ranging from electroencephalogram and cardiac rate and rhythm analyses to stock market and weather predictions. Psychiatric neuroscientists are now beginning to apply nonlinear met...

journal_title：Biological psychiatry

authors： Paulus MP,Braff DL

更新日期：2003-01-01 00:00:00

abstract：:The pharmacokinetics of dexamethasone (DEX) were studied in 9 drug-free melancholically depressed patients and 10 healthy control subjects matched by sex and age. Each subject received 1 mg of DEX administered orally and by the (i.v.) route at 11:00 PM and serial blood samples were collected over the next 17 hours unt...

journal_title：Biological psychiatry

authors： O'Sullivan BT,Cutler DJ,Hunt GE,Walters C,Johnson GF,Caterson ID

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Elevated endogenous levels of corticosteroids cause neural dysfunction and loss, especially within the hippocampus, as well as cognitive impairment in hippocampus-mediated tasks. Because Cushing's syndrome patients suffer from hypercortisolism, they represent a unique opportunity to study the impact of eleva...

journal_title：Biological psychiatry

authors： Grillon C,Smith K,Haynos A,Nieman LK

更新日期：2004-12-01 00:00:00