当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors.

Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors.

Abstract：

BACKGROUND:Identifying the underlying cellular mechanisms of episodic memory is an important challenge, since this memory, based on temporal and contextual associations among events, undergoes preferential degradation in aging and various neuropsychiatric disorders. Memory storage of temporal and contextual associations is known to rely on hippocampal N-methyl-D-aspartate receptor (NMDAR)-dependent synaptic plasticity, which depends ex vivo on dynamic organization of surface NMDARs. Whether NMDAR surface trafficking sustains the formation of associative memory, however, remains unknown. METHODS:We tested this hypothesis, using single nanoparticle imaging, electrophysiology, and behavioral approaches, in hippocampal networks challenged with a potent modulator of NMDAR-dependent synaptic plasticity and memory, 17β-estradiol (E2). RESULTS:We demonstrate that E2 modulates NMDAR surface trafficking, a necessary condition for E2-induced potentiation at hippocampal cornu ammonis 1 synapses. Strikingly, cornu ammonis 1 NMDAR surface trafficking controls basal and E2-enhanced mnemonic retention of temporal, but not contextual, associations. CONCLUSIONS:NMDAR surface trafficking and its modulation by the sex hormone E2 is a cellular mechanism critical for a major component of episodic memory, opening a new and noncanonical research avenue in the physiopathology of cognition.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Potier M,Georges F,Brayda-Bruno L,Ladépêche L,Lamothe V,Al Abed AS,Groc L,Marighetto A

doi

10.1016/j.biopsych.2015.07.017

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

735-745

issue

9

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(15)00611-3

journal_volume

79

pub_type

杂志文章

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